Review
Biochemistry & Molecular Biology
Silvia Gonzalez-Martinez, Belen Perez-Mies, David Pizarro, Tamara Caniego-Casas, Javier Cortes, Jose Palacios
Summary: Metaplastic breast carcinoma (MBC) is a rare triple negative invasive cancer with poor prognosis. The resistance mechanisms of MBC may involve epithelial-mesenchymal transition (EMT) and immune response, distinguishing it from other types of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong, Zhi Zheng
Summary: This study revealed that exosomal miR-27b derived from hucMSCs could reverse the EMT process induced by TGF-beta 2 by inhibiting HOXC6, suggesting the potential therapeutic role of the exosomal miR-27b/HOXC6 axis in ameliorating subretinal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Rachel Vazana-Netzarim, Yishay Elmalem, Shachar Sofer, Hod Bruck, Naama Danino, Udi Sarig
Summary: By seeding hMSCs on pcECM, we observed a partial mesenchymal-to-epithelial transition (MET) and identified the crucial role of HAND2 gene in this process. HAND2 and its associated non-coding RNA are expressed at different levels in various tissues, and deviation from these basal levels is associated with various pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Naiyou Liu, Charles M. Bowen, Mohammadali M. Shoja, Karen Larissa Castro de Pereira, Laxmi Priya Dongur, Antonio Saad, William K. Russell, Thomas Christopher Broderick, Jeffrey H. Fair, William Samuel Fagg
Summary: Myofibroblast activation is a cellular response to physiological or pathological insults. In this study, co-cultured amniotic cell conditioned media (coACCM) was found to activate myofibroblast, while amniotic fluid (AF) represses it. These findings suggest that different biologics can elicit different cellular responses and may have broad utility in the clinic and the lab.
Article
Biochemistry & Molecular Biology
Wenli Zhou, Zhennan Yun, Ting Wang, Chao Li, Jiantao Zhang
Summary: The study reveals the critical roles of BTF3 and BMI1 in colorectal cancer, influencing the stem cell-like traits and epithelial-mesenchymal transition of CRC cells to promote or inhibit metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Marcela Rodrigues de Camargo, Talita Fonseca Frazon, Kelly Karina Inacio, Fhernanda Ribeiro Smiderle, Nadia Ghinelli Amor, Thiago Jose Dionisio, Carlos Ferreira Santos, Camila Oliveira Rodini, Vanessa Soares Lara
Summary: The polysaccharides of Ganoderma lucidum have the potential to be an important ally for tongue squamous cell carcinoma treatment, as they can alter the behavior and morphology of tumor cells, as well as downregulate cancer stem cells and EMT markers.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo A. Acuna, Manuel Varas-Godoy, Diego Herrera-Sepulveda, Mauricio A. Retamal
Summary: Connexins are a family of proteins that play a crucial role in cellular communication, but certain types may have pro-tumorigenic effects. Research has shown that Cx46 can modulate the characteristics of cancer stem cells and epithelial-to-mesenchymal transition in breast cancer cells, potentially influencing future cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts, Mohammad Reza Abbaszadegan
Summary: This study reveals the crucial role of TWIST1 in the establishment of a cancer stem cell-like phenotype, EMT progression, and inhibition of apoptosis in esophageal squamous cell carcinoma (ESCC). These findings provide evidence for TWIST1 as a therapeutic target for suppressing CSC generation and ESCC malignancy.
Review
Oncology
Ioanna Akrida, Francesk Mulita, Kerasia-Maria Plachouri, Nikolaos Benetatos, Ioannis Maroulis, Helen Papadaki
Summary: This review summarizes the role of EMT in the pathogenesis of Metaplastic Breast Carcinoma (MBC) and Phyllodes tumors (PTs), and suggests several anti-EMT targeting strategies as promising therapeutic approaches for patients suffering from these aggressive neoplasms.
Review
Biochemistry & Molecular Biology
Inese Briede, Dainis Balodis, Janis Gardovskis, Ilze Strumfa
Summary: Colorectal carcinoma ranks third by incidence and second by mortality globally, with high numbers of advanced cases. Cancer stem cells present a challenge to the treatment of metastatic colorectal cancer, with intricate associations between inflammation, epithelial-mesenchymal transition, and cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shaoqiu Zheng, Jing Luo, Shoucheng Xie, Shanming Lu, Qinghua Liu, Huanqin Xiao, Wenjuan Luo, Yanfang Huang, Kun Liu
Summary: Recent evidence suggests that cancer stem cells (CSCs) are the origin of cancers. This study investigated the relationship between tumor buds, which are hypothesized to represent epithelial-mesenchymal transition (EMT)-like CSCs, and EMT and CSC markers in cervical squamous cell carcinoma (CxSCC). The findings indicate that tumor buds in CxSCC may represent EMT-like CSCs in vivo.
Article
Biochemistry & Molecular Biology
Deguang Kong, Hengbo Zhou, Deepika Neelakantan, Connor J. Hughes, Jessica Y. Hsu, Ramakrishnan Rajaram Srinivasan, Michael T. Lewis, Heide L. Ford
Summary: VEGF-C secreted by EMT breast cancer cells can promote proliferation, migration, and invasion of epithelial breast cancer cells through non-canonical activation of GLI signaling. Inhibiting VEGF-C in EMT cells or knocking down NRP2 in neighboring epithelial cancer cells disrupts the aggressive phenotypes induced by EMT cells, suggesting a novel therapeutic target for metastasis in breast cancer.
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ming Liang Oon, Michal M. Hoppe, Shuangyi Fan, The Phyu, Hoang M. Phuong, Soo-Yong Tan, Susan Swee-Shan Hue, Shi Wang, Li M. Poon, Hian L. E. Chan, Joanne Lee, Yen L. Chee, Wee-Joo Chng, Sanjay de Mel, Xin Liu, Anand D. Jeyasekharan, Siok-Bian Ng
LEUKEMIA & LYMPHOMA
(2019)
Letter
Pathology
Ming Liang Oon, Gwyneth Soon, Li Mei Poon, Shi Wang
Article
Pathology
Susan Swee-Shan Hue, Ming Liang Oon, Shi Wang, Soo-Yong Tan, Siok-Bian Ng
Article
Oncology
Ming Liang Oon, Jing Quan Lim, Bernett Lee, Sai Mun Leong, Gwyneth Shook-Ting Soon, Zi Wei Wong, Evelyn Huizi Lim, Zhenhua Li, Allen Eng Juh Yeoh, Shangying Chen, Kenneth Hon Kim Ban, Tae-Hoon Chung, Soo-Yong Tan, Shih-Sung Chuang, Seiichi Kato, Shigeo Nakamura, Emiko Takahashi, Yong-Howe Ho, Joseph D. Khoury, Rex K. H. Au-Yeung, Chee-Leong Cheng, Soon-Thye Lim, Wee-Joo Chng, Claudio Tripodo, Olaf Rotzschke, Choon Kiat Ong, Siok-Bian Ng
Summary: T-cells play a critical role in defending the human body against pathogens, with T-cell lymphomas characterized by malignant T-cells proliferating and forming genetically identical populations with the same TCR rearrangement pattern. A novel segmentation and copy number computation algorithm has been developed to accurately identify different TCR rearrangement patterns using whole genome sequencing data, potentially improving diagnostic accuracy for TCLs and having broader applications in hematology.
Article
Surgery
X. E. Chuang, D. Y. S. Chan, M. L. Oon, S. Wang, C. L. K. Chia
Summary: IMTs are rare tumors with unpredictable behavior. This case report describes an IMT in a NF1 patient presenting with intestinal obstruction, successfully treated with surgery.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2021)
Letter
Clinical Neurology
Ming Liang Oon, Sharon Y. Y. Low, Chik Hong Kuick, Jian Yuan Goh, Kenneth T. E. Chang, Roger E. McLendon, Char Loo Tan
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Letter
Hematology
Chrissie K. Lim, Youjia Zhong, Richard Hopkins, Wei-Xiang Sin, Bijin Veonice Au, Sriram Narayanan, Chiung-Hui Huang, Colin Y. C. Lee, Ming Liang Oon, Avisha Chowdhury, Benjamin Wong, Frances Yeap, Mariflor Villegas, Julien Pompon, Patricia P. L. Ng, Siok-Bian Ng, Thuan Chong Quah, Poh-Lin Tan, Keh-Chuang Chin, John E. Connolly
Article
Cell Biology
Ming Liang Oon, Nicholas L. Syn, Char Loo Tan, Kong-Bing Tan, Siok-Bian Ng
Summary: ChatGPT's diagnostic ability in histopathology is not as good as that of experts, and its help to experts is limited. However, it is recognized by experts as an advanced search engine.
Article
Pathology
Ming Liang Oon, Bingcheng Wu, Hian Lee Esther Chan, Fredrik Petersson
Summary: This study characterizes a rare case of orbital crystal-storing histiocytosis associated with extranodal marginal zone lymphoma and reports the frozen section features of crystal-storing histiocytosis for the first time.
HEAD & NECK PATHOLOGY
(2023)