期刊
AUTOPHAGY
卷 17, 期 8, 页码 2051-2052出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2021.1940610
关键词
Autophagy receptor; CALCOCO1; Golgi; Golgiphagy; Golgiphagy receptor; zDABM motif; ZDHHC17
类别
资金
- Research Council of Norway [249884]
- Norwegian Cancer Society [190214]
Cellular stress response mechanisms can lead to an increase in organellar quantity and volume, which are cleared through autophagy. A recent study identified CALCOCO1 as a receptor for Golgiphagy in response to nutrient deprivation.
Cellular stress response mechanisms typically increase organellar quantity and volume. To restore cellular homeostasis and organellar integrity, the surplus organelles are cleared by macroautophagy/autophagy, an intracellular process that shuttles cytoplasmic material to the lysosomes for degradation. The degradation is mediated by autophagy receptors that selectively link the degradable cargo to the autophagy machinery. Studies have identified receptors for the degradation of mitochondria, endoplasmic reticulum, lysosomes, and peroxisomes. The autophagic degradation of the Golgi, named Golgiphagy, however, has remained undefined. The Golgi is essential for the processing, sorting and trafficking of proteins and lipids in the secretory pathway. In a recent study, we identified CALCOCO1 as a Golgiphagy receptor in response to nutrient deprivation. CALCOCO1 interacts with Golgi membranes by binding to cytoplasmic Ankyrin repeat (AR) domains of Golgi resident ZDHHC17 and ZDHHC13 palmitoyltransferases (PATs) via a defined zDHHC-AR-binding motif (zDABM) to recruit autophagy machinery. Lack of CALCOCO1 in cells causes an impaired Golgiphagy and expansion of the Golgi.
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