期刊
EXPERIMENTAL AND MOLECULAR PATHOLOGY
卷 100, 期 3, 页码 386-392出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2016.03.003
关键词
CCE; IBD; VDR; TNBS; Pyroptosis
类别
资金
- Climbing Scholars Program
- Ten, Hundred, Thousand Program in the Liaoning Province of China
- Natural Science Foundation of China [81570811, 81170065]
The therapeutic effect of 1,25(OH)(2) vitamin D-3 and its analog (paricalcitol) on experimental colitis in animals has been heavily demonstrated. However, the response to Cholecalciterol Cholesterol Emulsion (CCE), a precursor of 1,25(OH)(2) vitamin D-3, has not yet been reported. Whether pyroptosis is involved in colitic deterioration also remains unclear. Therefore, we adopted molecular biology and histology approaches to examine mechanisms by which CCE was able to regulate experimental colitis in the animal model induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Our data revealed that mice displayed a remarkable reduction in colonic histological scores, colonic inflammation and colonic histological damage. In addition, there was an overall improvement in general status (change in body weight, food and water intake, mental status, activity) and a 30% increase in survival rate due to the downregulation of pyroptosis following treatment with CCE. In conclusion, our data have provided evidence that CCE can attenuate the damage of experimental colitis by suppressing pyroptosis signaling. (C) 2016 Elsevier Inc. All rights reserved.
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