Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning

The 3D reconstructed skin micronucleus assay using imaging flow cytometry and deep learning: a proof-of-principle investigation

(2021) Ashley Allemang et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cytokinesis-Block Micronucleus Cytome Assay Evolution into a More Comprehensive Method to Measure Chromosomal Instability

(2020) Michael Fenech   Genes

Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay

(2019) Qi Wang et al.   RADIATION RESEARCH

Deep learning for cellular image analysis

(2019) Erick Moen et al.   NATURE METHODS

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry

(2019) Matthew A. Rodrigues   Jove-Journal of Visualized Experiments

Nucleus segmentation across imaging experiments: the 2018 Data Science Bowl

(2019) Juan C. Caicedo et al.   NATURE METHODS

The potential for complete automated scoring of the cytokinesis block micronucleus cytome assay using imaging flow cytometry

(2018) Matthew A. Rodrigues et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Automation of the in vitro micronucleus assay using the Imagestream® imaging flow cytometer

(2018) Matthew A. Rodrigues   CYTOMETRY PART A

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro

(2018) Jatin R Verma et al.   MUTAGENESIS

Reconstructing cell cycle and disease progression using deep learning

(2017) Philipp Eulenberg et al.   Nature Communications

Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells

(2016) Jatin R. Verma et al.   ARCHIVES OF TOXICOLOGY

Optimized automated data analysis for the cytokinesis-block micronucleus assay using imaging flow cytometry for high throughput radiation biodosimetry

(2016) M. A. Rodrigues et al.   CYTOMETRY PART A

Validation of the Cytokinesis-block Micronucleus Assay Using Imaging Flow Cytometry for High Throughput Radiation Biodosimetry

(2016) Matthew A. Rodrigues et al.   HEALTH PHYSICS

Label-free cell cycle analysis for high-throughput imaging flow cytometry

(2016) Thomas Blasi et al.   Nature Communications

Automation of the cytokinesis-block micronucleus cytome assay by laser scanning cytometry and its potential application in radiation biodosimetry

(2016) Maxime François et al.   BIOTECHNIQUES

Enhanced γ-H2AX DNA damage foci detection using multimagnification and extended depth of field in imaging flow cytometry

(2015) Christopher N. Parris et al.   CYTOMETRY PART A

Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations

(2015) John W. Wills et al.   MUTAGENESIS

Multi-parameter dose estimations in radiation biodosimetry using the automated cytokinesis-block micronucleus assay with imaging flow cytometry

(2014) M. A. Rodrigues et al.   CYTOMETRY PART A

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment

(2014) G.E. Johnson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

RE: Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells (Mutagenesis, 29, 155–164, 2014)

(2014) Rebecca M. Maertens et al.   MUTAGENESIS

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

(2014) A. L. Seager et al.   MUTAGENESIS

Automated analysis of the cytokinesis-block micronucleus assay for radiation biodosimetry using imaging flow cytometry

(2014) M. A. Rodrigues et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Shape and steepness of toxicological dose–response relationships of continuous endpoints

(2013) Wout Slob et al.   CRITICAL REVIEWS IN TOXICOLOGY

Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment

(2013) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance

(2011) Micheline Kirsch-Volders et al.   ARCHIVES OF TOXICOLOGY

In vitro primary human lymphocyte flow cytometry based micronucleus assay: simultaneous assessment of cell proliferation, apoptosis and MN frequency

(2011) M. Lukamowicz et al.   MUTAGENESIS

Genotoxicity screening via the γH2AX by flow assay

(2011) D.J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

(2010) A. Rossnerova et al.   MUTAGENESIS

Automated image analysis of micronuclei by IMSTAR for biomonitoring

(2010) I. Decordier et al.   MUTAGENESIS

Laser scanning cytometry for automation of the micronucleus assay

(2010) Z. Darzynkiewicz et al.   MUTAGENESIS

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships

(2010) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Automated micronucleus (MN) scoring for population triage in case of large scale radiation events

(2009) Petra Willems et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring

(2008) I. Decordier et al.   MUTAGENESIS

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

(2007) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS