Identification and characterization of mutations in the SARS-CoV-2 RNA-dependent RNA polymerase as a promising antiviral therapeutic target

Discovering Potential RNA Dependent RNA Polymerase Inhibitors as Prospective Drugs Against COVID-19: An in silico Approach

(2021) Satabdi Saha et al.   Frontiers in Pharmacology

Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2

(2021) Niti Yashvardhini et al.   Canadian Journal of Infectious Diseases & Medical Microbiology

Immunological and mutational analysis of SARS-CoV-2 structural proteins from Asian countries

(2021) Deepak Kumar Jha et al.   Biomedical Research and Therapy

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

(2020) Maria Pachetti et al.   Journal of Translational Medicine

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

(2020) Ashleigh Shannon et al.   ANTIVIRAL RESEARCH

Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution

(2020) Naveen Vankadari   GENE

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

(2020) Chandra Bhushan Mishra et al.   BRIEFINGS IN BIOINFORMATICS

Remdesivir Strongly Binds to Both RNA-Dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations

(2020) Hoang Linh Nguyen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability

(2018) Carlos HM Rodrigues et al.   NUCLEIC ACIDS RESEARCH

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Why are RNA virus mutation rates so damn high?

(2018) Siobain Duffy   PLOS BIOLOGY

Mutation-Driven Parallel Evolution during Viral Adaptation

(2017) Andrew M Sackman et al.   MOLECULAR BIOLOGY AND EVOLUTION

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels

(2015) Yongwook Choi et al.   BIOINFORMATICS

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase

(2011) Leen Delang et al.   ANTIVIRAL RESEARCH