期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 44, 期 1, 页码 12-19出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000065
关键词
endothelial dysfunction; chronic kidney disease; nitric oxide; l-arginine; CAT-1; aerobic exercise
资金
- National Institutes of Health [DK080469, GM103446, HL113514]
- ACSM Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL113514] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R15DK080469] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103446] Funding Source: NIH RePORTER
Endothelial dysfunction occurs in chronic kidney disease (CKD) and increases the risk for cardiovascular disease. The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression, culminating in reduced l-arginine transport and impaired nitric oxide bioavailability in advanced disease. This review examines the hypothesis that aerobic exercise may reverse endothelial dysfunction by improving endothelial cell l-arginine uptake in CKD.
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