Article
Medicine, General & Internal
Yuma Fuse, Ryo Karakawa, Tomoyuki Yano, Hidehiko Yoshimatsu
Summary: The study evaluated the efficacy of lymph-venous anastomosis (LVA) for breast cancer-related lymphoedema (BCRL) patients with a history of docetaxel use. Results showed that LVA was comparably effective for patients who had undergone docetaxel-based chemotherapy before or after axillary lymph node dissection (ALND).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Fahime Shahsavari, Mohsen Bakhshi Kashi, Saeed Farzanefar, Elisabeth Eppard, Nasim Vahidfar
Summary: Breast cancer is a deadly malignancy, and early and accurate diagnosis is crucial for long-term survival. Nuclear medicine has recently introduced a novel method for evaluating breast cancer at both early and advanced stages. This method is based on sentinel lymph node scintigraphy, which is preferable to axillary lymphadenectomy due to its lower postoperative complications. Radiocolloids have shown superior effectiveness in detecting metastatic lymph nodes. In this short review, we will introduce the important role of radiopharmaceuticals in the clinical application of breast cancer lymphoscintigraphy.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Review
Oncology
Ceren Gursen, Elizabeth Sian Dylke, Niamh Moloney, Mira Meeus, Tessa De Vrieze, Nele Devoogdt, An De Groef
Summary: The most commonly reported symptoms in breast cancer patients with ULL are swelling and heaviness, with tenderness and numbness being common in non-ULL patients. Self-reported symptoms such as larger arm size, feelings of tightness, stiffness, puffiness, pain, sensory disturbances, and functional changes may predict the development of ULL. The presence of swelling and heaviness are moderately correlated with the presence and severity of ULL.
EUROPEAN JOURNAL OF CANCER CARE
(2021)
Article
Oncology
Christopher J. Coroneos, Wendy A. Woodward, Franklin C. Wong, Abigail S. Caudle, Simona F. Shaitelman, Henry M. Kuerer, Mark Schaverien
Summary: This study characterized the physiological drainage of the normal upper extremity using SPECT/CT lymphoscintigraphy ARM. The upper extremity SLN was found in a constant region of the axilla, with secondary lymph nodes predominantly located in the upper inner quadrant when the SLN was in the upper outer quadrant. Results can be directly applied clinically to ARM techniques and adjuvant radiation planning.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Tibor A. Zwimpfer, Fabienne D. Schwab, Daniel Steffens, Felix Kaul, Noemi Schmidt, James Geiger, Franziska Geissler, Viola Heinzelmann-Schwarz, Walter P. Weber, Christian Kurzeder
Summary: In this case report, a 37-year-old patient with CALNM in a ipsilateral relapse of breast cancer is described. The use of delayed lymphoscintigraphy and the sentinel procedure aided in accurate staging and treatment. The findings suggest that CALNM without evidence of systemic metastasis should be considered a regional event in recurrent breast cancer, allowing for a curative approach.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sandra C. Hayes, Matthew Dunn, Melanie L. Plinsinga, Hildegard Reul-Hirche, Yumeng Ren, E-Liisa Laakso, Melissa A. Troester
Summary: This study found that upper-body symptoms are common in women with invasive breast cancer and are associated with poorer upper-body function, lower physical activity levels, and lower quality of life. Furthermore, the presence of these symptoms may predict an increased risk of developing breast cancer-related lymphoedema (BCRL).
Review
Surgery
Nur Amalina Che Bakri, Richard M. Kwasnicki, Naairah Khan, Omar Ghandour, Alice Lee, Yasmin Grant, Aleksander Dawidziuk, Ara Darzi, Hutan Ashrafian, Daniel R. Leff
Summary: This study evaluated the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb morbidity in breast cancer patients. The results showed that ALND patients had higher prevalence of lymphedema, pain, reduced strength, and range of motion compared with SLNB patients. These findings support the continued de-escalation of axillary surgery.
Article
Oncology
Thais Cristina Siqueira, Simone Pedrozo Fragoas, Andreia Pelegrini, Ana Rosa de Oliveira, Clarissa Medeiros da Luz
Summary: The study revealed that over half of women experience upper limb dysfunction after breast cancer treatment, with intercostobrachial nerve injury being associated with such dysfunction. Age and body mass index do not have a significant impact on this association.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Se Hyun Oh, Ju Hyeon Kim, Seung Tae Seong, Jun Young Park, Jae Hyun Lee, Ghi Chan Kim, Ho Joong Jeong, Young Joo Sim
Summary: This study investigated the impact of axillary site radiation therapy on lymphoscintigraphy in breast cancer-related lymphedema patients who underwent sentinel lymph node dissection. The results suggest that both SLND and aRTx affect the activity of axillary lymph nodes and adversely affect lymphatic flow, becoming risk factors for lymphedema. Additionally, lymphedema may develop even in patients with normal lymphoscintigraphy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sergi Vidal-Sicart, Maria Eugenia Rioja, Andrea Prieto, Elena Goni, Isabel Gomez, Maria Dolores Albala, Luis Lumbreras, Luisa Fernanda Leon, Jose Ramon Gomez, Francisco Campos
Summary: Tc-99m-tilmanocept demonstrated good results in a heterogeneous breast cancer population, with the best outcomes achieved when a superficial injection was chosen. The lymphoscintigraphy showed higher SLN detection rates in patients with normal weight compared to overweight or obese patients. Additionally, injection site and tumor markers had an impact on preoperative SLN visualization and intraoperative localization.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Orthopedics
Elizabeth Dylke
Summary: This article discusses the measurement methods and techniques for breast cancer-related lymphoedema and evaluates and compares them. The results of the study provide effective methods for assessing patients' lymphoedema and guiding appropriate treatment measures.
JOURNAL OF PHYSIOTHERAPY
(2022)
Article
Oncology
Amy K. Schulze, Tanya L. Hoskin, Mary M. Mrdutt, Robert W. Mutter, Tina J. Hieken
Summary: This study explores the feasibility and therapeutic impact of repeat sentinel lymph node surgery in patients with local recurrence post-mastectomy. The results show that this approach is successful and informative, reducing axillary dissection rates and potentially guiding adjuvant radiation target volumes and systemic therapies.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Makoto Mihara, Hisako Hara, Yohei Kawasaki, Toshiharu Mitsuhashi, Hideki Orikasa, Hirohiko Ando, Munekazu Naito
Summary: This multicentre RCT evaluated the effect of lymphatic venous anastomosis on the prevention of cellulitis. Results showed that lymphatic venous anastomosis combined with non-operative decongestive therapy was more effective in preventing cellulitis compared to non-operative decongestive therapy alone.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Oncology
Taynara Louisi Pilger, Daniely Franco Francisco, Francisco Jose Candido dos Reis
Summary: Axillary surgery, including sentinel lymph node biopsy (SLNB), remains essential in managing early breast cancer, with potential postoperative complications such as lymphedema, pain, sensory, and motor disorders. Despite being less invasive than traditional axillary node dissection, SLNB still presents a risk of ipsilateral arm complications, with incidences of 0-11% lymphedema, 11-16% pain, 2-22% sensory disorders, and 0-9% motor disorders six months post-surgery.
Article
Nursing
Patricia Martinez-Jaimez, Miriam Armora Verdu, Carlos G. Forero, Samantha Alvarez Salazar, Pilar Fuster Linares, Cristina Monforte-Royo, Jaume Masia
Summary: This study aimed to identify risk factors for lymphoedema following ALND in a European sample and propose a prediction model. The model included factors such as lymph node dissection level, status, post-operative complications, BMI, and number of lymph nodes extracted, showing good sensitivity in predicting lymphoedema risk. Nurses play a key role in providing holistic care and the model offers a tool for assessing lymphoedema risk in women undergoing ALND.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Oncology
Patriek Jurrius, Thomas Green, Hans Garmo, Matthew Young, Massimiliano Cariati, Cheryl Gillett, Anca Mera, Mark Harries, Anita Grigoriadis, Sarah Pinder, Lars Holmberg, Arnie Purushotham
Article
Oncology
Camille Maringe, James Spicer, Melanie Morris, Arnie Purushotham, Ellen Nolte, Richard Sullivan, Bernard Rachet, Ajay Aggarwal
Article
Radiology, Nuclear Medicine & Medical Imaging
Patriek A. G. T. Jurrius, Maarten R. Grootendorst, Marika Krotewicz, Massimiliano Cariati, Ashutosh Kothari, Neill Patani, Paulina Karcz, Monika Nagadowska, Kunal N. Vyas, Arnie Purushotham, Maria Turska-d'Amico
Summary: The study shows that [F-18]FDG FAR is a feasible and safe method for intraoperative assessment of breast cancer tumor margins, with a certain accuracy in distinguishing invasive carcinoma and DCIS. In the high-activity cohort, sensitivity and positive predictive value are increased, and radiation exposure to operating theatre staff is low.
Article
Oncology
Toral Gathani, Anushka Chaudhry, Leena Chagla, Sharat Chopra, Ellen Copson, Arnie Purushotham, Raghavan Vidya, Ramsey Cutress
Summary: Outcomes for women with breast cancer in the UK have significantly improved in recent decades, largely due to early diagnosis and free treatments provided by the National Health Service. Concerns exist that ethnic minority groups, making up around 15% of the UK population, may experience poorer outcomes. This report aims to summarize current evidence on breast cancer incidence and outcomes in ethnic minority women in the UK to raise awareness and identify areas for future research.
Review
Oncology
Priya Ranganathan, Girish Chinnaswamy, Manju Sengar, Durga Gadgil, Shivakumar Thiagarajan, Balram Bhargava, Christopher M. Booth, Marc Buyse, Sanjiv Chopra, Chris Frampton, Satish Gopal, Nick Grant, Mark Krailo, Ruth Langley, Prashant Mathur, Xavier Paoletti, Mahesh Parmar, Arnie Purushotham, Douglas Pyle, Preetha Rajaraman, Martin R. Stockler, Richard Sullivan, Soumya Swaminathan, Ian Tannock, Edward Trimble, Rajendra A. Badwe, C. S. Pramesh
Summary: Low-income and middle-income countries bear a disproportionate burden of cancer and mortality, necessitating context-specific research. Training early career researchers is crucial to improve research output and cancer outcomes in LMICs. Initiatives like CReDO workshop aim to address gaps in research training and increase capacity in oncology research, with positive impact shown through participant progress and research initiation.
Article
Multidisciplinary Sciences
Rajbir Nath Batra, Aviezer Lifshitz, Ana Tufegdzic Vidakovic, Suet-Feung Chin, Ankita Sati-Batra, Stephen-John Sammut, Elena Provenzano, H. Raza Ali, Ali Dariush, Alejandra Bruna, Leigh Murphy, Arnie Purushotham, Ian Ellis, Andrew Green, Francine E. Garrett-Bakelman, Chris Mason, Ari Melnick, Samuel A. J. R. Aparicio, Oscar M. Rueda, Amos Tanay, Carlos Caldas
Summary: Understanding the molecular mechanisms of DNA methylation in cancer is important, and this study analyzed RRBS profiles of breast tumors and normal tissues to uncover epigenomic instability and cis-regulatory effects. The findings suggest that global epigenetic instability can affect cancer methylomes and lead to localized methylation aberrations in-cis, resulting in transcriptional changes seen in tumors.
NATURE COMMUNICATIONS
(2021)
Article
Health Care Sciences & Services
Ramachandran Venkataramanan, Akash Pradhan, Abhishek Kumar, Arnie Purushotham, Mohannad Alajlani, Theodoros N. Arvanitis
Summary: The COVID-19 pandemic has disrupted cancer care services delivery, but it has also led to the emergence of a new model heavily relying on digital mediums. Digital health provides additional benefits including cancer screening, early and accurate diagnosis, and increased access to specialized care. However, challenges remain for large-scale adoption. Factors such as age, literacy, and socio-cultural norms act as barriers for users, while providers face regulatory issues, data security concerns, and inconvenience associated with system transition.
FRONTIERS IN DIGITAL HEALTH
(2022)
Article
Health Policy & Services
Kunal Oswal, Rishav Kanodia, Neha Kharodia, Akash Pradhan, Neha Gupta, Ajita Singh, Lakshman Sethuraman, Ramachandran Venkataramanan, Carlo Caduff, Arnie Purushotham
Summary: Cancer patients in the North East Region of India have poorer survival rates due to late stage at presentation related to poor awareness of risk factors such as tobacco and alcohol use, and less physical activity. This study found that tobacco and alcohol use was highest among males, aged 25-44, and middle income group. Over 90% of users started tobacco and alcohol between 10-30 years old, and 62% of participants rarely or never engaged in physical recreational activity.
JOURNAL OF CANCER POLICY
(2021)
Article
Health Policy & Services
Kunal Oswal, Rishav Kanodia, Umakant Nadkar, Neha Kharodia, Mahendra Avhad, Ramachandran Venkataramanan, Lakshman Sethuraman, Carlo Caduff, Arnie Purushotham
Summary: The study assessed the cancer patients' experience in Assam and found that while overall patients had good experiences during registration, first consultation, and treatment, challenges such as financial constraints and geographical distance were identified. Areas for improvement include better explanation of long-term side effects of treatment and enhanced guidance on treatment options, as well as increased support for patients to cope with the psychological, emotional, and physical aspects of their cancer diagnosis, treatment, and recovery.
JOURNAL OF CANCER POLICY
(2021)
Article
Oncology
Nandini Vallath, Rewati Raman Rahul, Tanma Mahanta, Dipankar Dakua, Pranjal Protim Gogoi, Ramchandran Venkataramanan, Lakshman Sethuraman, H. M. Iqbal Bahar, Kabindra Bhagabati, Dinesh Goswami, Arnie Purushotham
Summary: This project describes the strategies used to integrate palliative care services with comprehensive cancer care initiatives in Assam, India, highlighting the informed regional adaptation of the WHO model. It emphasizes the sustainability of services activated within public healthcare systems and the relevance of this model for LMIC regions with similar health systems.
JCO GLOBAL ONCOLOGY
(2021)
Article
Oncology
Arvind Kumar, Kunal Oswal, Ravikant Singh, Neha Kharodia, Akash Pradhan, Lakshman Sethuraman, Ramachandran Venkataramanan, Arnie Purushotham
Summary: Areca nut (betel nut) consumption is a major concern in India and Southeast Asian countries, with increasing use globally. The study found that betel quid with tamul was the most common form of areca nut chewing, with high levels of pleasure and stress relief reported by users. Despite some attempts to quit, a large percentage of users believed it was highly addictive, indicating a need for refined strategies for control and engagement with stakeholders.
ECANCERMEDICALSCIENCE
(2021)
Article
Oncology
Arnie Purushotham, Graham Roberts, Kate Haire, Joanna Dodkins, Elizabeth Harvey-Jones, Lu Han, Anne Rigg, Claire Twinn, Conjeevaram Pramesh, Priya Ranganathan, Richard Sullivan, Ajay Aggarwal
Summary: The COVID-19 pandemic led to a significant decrease in cancer diagnoses and an increase in the proportion of patients presenting at advanced stages, particularly for prostate, breast, and lung cancers. This highlights the need for balanced public health measures to prioritize cancer patients for timely diagnosis and treatment during future waves of the pandemic.
ECANCERMEDICALSCIENCE
(2021)
Article
Health Policy & Services
Kunal Oswal, Rishav Kanodia, Akash Pradhan, Mahendra Avhad, Lakshman Sethuraman, Neha Kharodia, Ramachandran Venkataramanan, Carlo Carduff, Arnie Purushotham
JOURNAL OF CANCER POLICY
(2020)
Article
Substance Abuse
Akash Pradhan, Kunal Oswell, Asim Padhan, Sanjay Seth, Ashima Sarin, Lakshman Sethuraman, Paul Sebastian, Arnie Purushotham
TOBACCO PREVENTION & CESSATION
(2020)
Article
Oncology
Kunal Oswal, Rishav Kanodia, Akash Pradhan, Umakant Nadkar, Mahendra Avhad, Ramachandran Venkataramanan, Lakshman Sethuraman, Carlo Caduff, Arnie Purushotham
JCO GLOBAL ONCOLOGY
(2020)