期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 193, 期 12, 页码 4151-4171出版社
SPRINGER
DOI: 10.1007/s12010-021-03672-z
关键词
Lactic acid; Strain modification technology; Cheap raw materials
资金
- Major Program of the Inner Mongolia Autonomous Region of China [2019ZD021]
- National Natural Science Foundation of China Large Science Installation Joint Fund Cultivation Project [U1932141]
- National Natural Science Foundation of China Large Science Installation Fund Project [U2032210]
The article summarizes the latest technological developments in lactic acid production, including efficient strain modification technology and the use of low-cost raw materials to reduce production costs, while also discussing the future prospects for development.
Lactic acid can synthesize high value-added chemicals such as poly lactic acid. In order to further minimize the cost of lactic acid production, some effective strategies (e.g., effective mutagenesis and metabolic engineering) have been applied to increase productive capacity of lactic acid bacteria. In addition, low-cost cheap raw materials (e.g., cheap carbon source and cheap nitrogen source) are also used to reduce the cost of lactic acid production. In this review, we summarized the recent developments in lactic acid production, including efficient strain modification technology (high-efficiency mutagenesis means, adaptive laboratory evolution, and metabolic engineering), the use of low-cost cheap raw materials, and also discussed the future prospects of this field, which could promote the development of lactic acid industry.
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