期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37
卷 37, 期 -, 页码 469-493出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-120319-030931
关键词
morphogenesis; self-organization; coarse-graining; mechanobiology; mechanical feedback; closed-loop dynamics
资金
- European Research Council (ERC-2018-COG grant) [819174]
- United States-Israel Binational Science Foundation [2017158]
- European Research Council (ERC) [819174] Funding Source: European Research Council (ERC)
Morphogenesis is a significant example of biological pattern formation but the underlying organizational principles remain not fully understood. The coordination between mechanical and biochemical processes, as well as the value of a coarse-grained approach, are essential for understanding this process. Identifying relevant coarse-grained variables and developing effective theories are key challenges in developing an integrated framework for understanding this remarkable pattern-formation process.
Morphogenesis is one of the most remarkable examples of biological pattern formation. Despite substantial progress in the field, we still do not understand the organizational principles responsible for the robust convergence of the morphogenesis process across scales to form viable organisms under variable conditions. Achieving large-scale coordination requires feedback between mechanical and biochemical processes, spanning all levels of organization and relating the emerging patterns with the mechanisms driving their formation. In this review, we highlight the role of mechanics in the patterning process, emphasizing the active and synergistic manner in which mechanical processes participate in developmental patterning rather than merely following a program set by biochemical signals. We discuss the value of applying a coarse-grained approach that considers the large-scale dynamics and feedback and complements the reductionist approach focused on molecular detail. A central challenge in this approach is identifying relevant coarse-grained variables and developing effective theories that can serve as a basis for an integrated framework toward understanding this remarkable pattern-formation process.
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