Article
Plant Sciences
Nian Liu, Jilei Li, Yichong Wang, Shengsheng Zhang
Summary: This study compared the efficacy and safety of different Chinese herbal medicine (CHM) therapies for diarrhea-predominant irritable bowel syndrome (IBS-D). The results showed that Jianpiwenshen Therapy (JPWS) and Shuganjianpiwenshen Therapy (SGJP) were the most effective CHM therapies for IBS-D, improving clinical symptoms and reducing adverse events.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Ya Zheng, Jessica Ching, Chung Wah Cheng, Wai Ching Lam, Kam Leung Chan, Xuan Zhang, Pui Yan Lam, Xing Yao Wu, Linda L. D. Zhong, Pei Hua Cao, Cho Wing Lo, Pui Kuan Cheong, Zhixiu Lin, Matthew Koh, Justin Wu, Zhao Xiang Bian
Summary: This study aims to evaluate the efficacy and safety of Chinese medicine JCM-16021 for IBS-D through a multi-center, randomized, double-blind, placebo-controlled clinical trial. The research hopes to provide more evidence to support Chinese medicine treatment for IBS-D.
Article
Medicine, Research & Experimental
Shi-Bing Liang, Mei Han, Hong-Jie Cheng, Qiao-Yan Zhang, Nai-Wei Zhang, Bo-Yi Jia, Nicola Robinson, Jian-Ping Liu
Summary: This study aims to evaluate the therapeutic effects and safety of the Chinese herbal formula Tongxie Yaofang (TXYF) for diarrhea-predominant irritable bowel syndrome (IBS-D) in adults. The trial will provide important data to guide the clinical practice of TXYF for the treatment of IBS-D in adults.
Article
Integrative & Complementary Medicine
Si-qi Tang, Yun-liang Wang, Zi-ye Xie, Yang Zhang, Yi Guo, Kang-li Gao, Tang-you Mao, Chun-e Xie, Jun-xiang Li, Xiao-yan Gao
Summary: This study revealed through serum metabolomics that different TCM syndrome types in IBS-D may exhibit distinct metabolic patterns, with glycerophospholipid metabolism being a significant pathway affected differently among the three TCM syndromes.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Review
Pharmacology & Pharmacy
Hui Zheng, Song Jin, Yin-Li Shen, Wen-Yan Peng, Kun Ye, Tai-Chun Tang, Jun Zhao, Min Chen, Zhi-Gang Li
Summary: This study found that Chinese herbal medicine is effective in relieving IBS symptoms but may cause a higher rate of adverse events compared to placebo. The findings were confirmed through trial sequential analysis with sufficient information size.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Kyoungmi Jung, Areum Kim, Ji-Hae Lee, Donghyun Cho, Juyeon Seo, Eun Sung Jung, Hye-ji Kang, Jonghwa Roh, Wangi Kim
Summary: The study demonstrated that Lactiplantibacillus plantarum APsulloc 331261 (GTB1®) is effective in providing relief for patients with diarrhea-predominant irritable bowel syndrome (IBS-D), reducing abdominal pain severity and frequency, improving diarrhea frequency, and enhancing overall quality of life.
Article
Gastroenterology & Hepatology
Isabelle Mack, Juliane Schwille-Kiuntke, Nazar Mazurak, Beate Niesler, Kurt Zimmermann, Hubert Moennikes, Paul Enck
Summary: This study investigated the effectiveness of a nonviable probiotic lysate (BL) in the treatment of IBS and found that BL was not effective for all IBS subtypes, but may offer a treatment option for IBS-D which needs further verification through adequately powered drug trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaohui Guo, Meiling Xuan, Huan Zheng, Shumin Qin, Haomeng Wu, Shaogang Huang, Zehuai Wen
Summary: This is a double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of HXZQ for IBS-D patients.
Review
Pharmacology & Pharmacy
Shi-Bing Liang, Hui-Juan Cao, Ling-Yao Kong, Jia-Li Wei, Nicola Robinson, Si-Hong Yang, Si-Jia Zhu, Yu-Qi Li, Yu-Tong Fei, Mei Han, Jian-Ping Liu
Summary: Standard Tongxie Yaofang (S-TXYF) may have therapeutic effects on diarrhea-predominant irritable bowel syndrome (IBS-D), improving stool consistency, frequency, abdominal pain, and quality of life, as well as relieving anxiety. However, due to the overall inadequate design of the included trials, more rigorous trials are needed to establish confirmed evidence of its benefits and safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
MaryJane O. Williams, Mary Sedarous, Brittany Dennis, Vanessa Dlamini, Obioma Nwaiwu, Linda Nguyen, Philip N. Okafor
Summary: Analysis of 12 irritable bowel syndrome trials revealed a median FI of 6, suggesting how easily statistical significance based on a threshold p-value may be overturned.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Integrative & Complementary Medicine
Yan-Qi Dai, Heng Weng, Qing Wang, Xiu-Jun Guo, Qiong Wu, Lin Zhou, Li Huang
Summary: This study aimed to evaluate the efficacy of moxibustion in treating diarrhea-predominant irritable bowel syndrome (IBS-D). Meta-analysis of 11 randomized controlled trials revealed that moxibustion treatment had superior effects compared to other positive treatments. Further rigorously designed and large-scale RCTs are needed to provide more robust evidence.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2022)
Review
Medicine, General & Internal
Tiantian Dong, Xuhao Li, Xin Ma, Xiqing Xue, Yi Hou, Yuanxiang Liu, Jiguo Yang
Summary: This study aims to evaluate the efficacy and safety of moxibustion in the treatment of diarrhea-predominant irritable bowel syndrome, with the ultimate goal of providing evidence on whether moxibustion therapy is beneficial for this condition through systematic evaluation and network meta-analysis.
Review
Pharmacology & Pharmacy
Hyejin Jun, Seok-Jae Ko, Keumji Kim, Jinsung Kim, Jae-Woo Park
Summary: This study assessed the methodology and quality of evidence of systematic reviews (SRs) on the use of herbal medicines (HMs) for irritable bowel syndrome (IBS). The findings suggest that HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence were generally low. Well-designed randomized controlled trials are needed to better evaluate the safety and efficacy of HM in IBS treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Jiajie Zhu, Yu Guo, Shan Liu, Xiaolan Su, Yijie Li, Yang Yang, Liwei Hou, Guishu Wang, Jiaxin Zhang, Jiande J. D. Chen, Qingguo Wang, Ruhan Wei, Wei Wei
ACUPUNCTURE IN MEDICINE
(2017)
Article
Multidisciplinary Sciences
Yan Chen, Yu Guo, Payam Gharibani, Jie Chen, Florin M. Selaru, Jiande D. Z. Chen
Summary: In patients with ulcerative colitis, inflammation affects colonic motility and rectal sensitivity. During active inflammation, colon transit accelerates and rectal compliance is unaffected, but rectal hypersensitivity is noted. Plasma acetylcholine decreases, while nerve growth factor increases during and after inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Hiren R. Modi, Qihong Wang, Sarah J. Olmstead, Elizabeth S. Khoury, Nirnath Sah, Yu Guo, Payam Gharibani, Rishi Sharma, Rangaramanujam M. Kannan, Sujatha Kannan, Nitish V. Thakor
Summary: This study demonstrates that early intervention with dendrimer-N-acetylcysteine conjugate (D-NAC) can improve post-cardiac arrest survival rate, motor deficits, and neurological recovery by targeting activated microglial cells and attenuating neuroinflammation. Early therapeutic intervention with a single dose of D-NAC shows sustained improvement in long-term outcomes, providing a promising approach for treating post-cardiac arrest syndrome.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Critical Care Medicine
Yu Guo, Sung-Min Cho, Zhiliang Wei, Qihong Wang, Hiren R. Modi, Payam Gharibani, Hanzhang Lu, Nitish Thakor, Romergryko G. Geocadin
Summary: This study investigated the characteristics of regional cerebral reperfusion after cardiac arrest resuscitation and its correlation with neurological recovery. The recovery of cerebral blood flow in the hippocampus and thalamus was found to be positively associated with better neurological outcomes. Additionally, the cerebral blood flow in the thalamus and cortex was positively correlated with neurological recovery.
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Ze Ou, Yu Guo, Payam Gharibani, Ariel Slepyan, Denis Routkevitch, Anastasios Bezerianos, Romergryko G. Geocadin, Nitish V. Thakor
Summary: Cardiac arrest (CA) is the main cause of coma, and early recovery indicators are needed to allocate resources properly. High-frequency oscillations (HFOs) of somatosensory evoked potentials (SSEPs) have been shown to indicate wakefulness following CA. However, their potential in the acute recovery phase has not been tested. We hypothesized that time-frequency (TF) analysis of HFOs can determine arousal recovery in this phase.
Article
Clinical Neurology
Yu Guo, Payam Gharibani, Prachi Agarwal, Sung-Min Cho, Nitish V. Thakor, Romergryko G. Geocadin
Summary: This study investigates the dynamic changes in autonomic and cortical function during the hyperacute stage of post-resuscitation and finds that the recovery of autonomic and cortical function is associated with favorable functional outcomes. This observation presents an opportunity for developing novel interventions for better monitoring and intervention during the early periods post-resuscitation.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Integrative & Complementary Medicine
Jiajie Zhu, Shan Liu, Yu Guo, Liwei Hou, Xiaolan Su, Yijie Li, Boyu Han, Dengke Liu, Qingguo Wang, Jiande J. D. Chen, Wei Wei
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)