Article
Pharmacology & Pharmacy
Andi Chen, Xiaohui Chen, Jianhui Deng, Jianjie Wei, Haitao Qian, Yongxin Huang, Shuyan Wu, Fei Gao, Cansheng Gong, Yanling Liao, Xiaochun Zheng
Summary: Hypoxic-ischemic brain damage (HIBD) is the main cause of neurological dysfunction in neonates. Olfactory cognitive dysfunction is important for feeding, the ability to detect hazardous situations, and social relationships. Dexmedetomidine (DEX) treatment could significantly improve olfactory cognitive dysfunction in neonatal rats with HIBD by promoting neurogenesis in the subventricular zone (SVZ) and enhancing the expression of brain-derived neurotrophic factor (BDNF) in microglia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yajin Yuan, Lijun Liu, Yao Du, Ruoxi Fan, Rongping Zhang, Ningna Zhou
Summary: p-HBA promotes astrocyte-to-neuron conversion and angiogenesis, protecting the structure of the neurovascular unit and alleviating motor impairment in a rat model of cerebral ischemia. This conversion pattern ensures the stability of brain structure and preserves the beneficial role of glial scar in the subacute phase.
Article
Cell Biology
Rajshekhar A. Kore, Xianwei Wang, Zufeng Ding, Robert J. Griffin, Alan J. Tackett, Jawahar L. Mehta
Summary: MSC exosomes show significant effects in limiting and reversing cardiac injury, particularly in the peri-infarct areas. By suppressing inflammation and pro-apoptotic processes, especially in the peri-infarct areas, they exert cardioprotective effects leading to preservation of cardiac function.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Muleiro Alvarez, Felipe Esparza Salazar, Thomas Rodriguez, Francesco D'Egidio, Cesar V. Borlongan, Jea-Young Lee
Summary: This study investigates the role of extracellular vesicles in endogenous repair within the neurovascular unit after ischemic stroke. The findings suggest that CD63 exosomes are spatially and temporally associated with glial activation, neurogenesis, and angiogenesis, indicating their potential contribution to the repair of the neurovascular unit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Ping-Ping Han, Yu Han, Xin-Ya Shen, Zhen-Kun Gao, Xia Bi
Summary: Stroke is a common cerebrovascular disease that interrupts local blood flow in the brain, causing neuronal damage or death and resulting in neurological dysfunction. Neuroplasticity, an important neurological function, helps neurons reorganize and regain function after injury. An enriched environment promotes increased neuroplasticity, aiding stroke recovery. This review discusses the positive effects of the enriched environment on neuroplasticity after cerebral ischemia, including synaptic plasticity, neurogenesis, and angiogenesis. Studies on the clinical application of enriched environments in the rehabilitation of post-stroke patients are also introduced, providing inspiration for new approaches to stroke rehabilitation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Stefan Milde, Guy C. Brown
Summary: This study suggests that microglial phagocytosis of stressed neurons mediated by P2Y(6) receptor plays a role in the delayed neuronal loss after stroke, and targeting the P2Y(6) receptor could potentially prevent peri-infarct neuronal loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xuemei Zong, Jie Gu, Siqi Zhou, Ding Ding, Yuting Hu, Lorelei Tucker, Zhihai Huang, Deqin Geng, Dianshuai Gao
Summary: The study shows that continuous theta-burst stimulation (cTBS) can promote neurogenesis and improve functional recovery after stroke. cTBS treatment expands the pool of neural progenitor cells and new neurons, reduces cell loss, and promotes the generation of mature neurons. cTBS also upregulates the release of neurotrophic factors, protects neural progenitor cells, and suppresses excessive gliogenesis.
Article
Biotechnology & Applied Microbiology
Cheng Wang, Xuewei Yang, Yixu Jiang, Lin Qi, Deli Zhuge, Tongtong Xu, Yiyan Guo, Mingwu Deng, Wenjie Zhang, Dongyan Tian, Qingqing Yin, Li Li, Zhijun Zhang, Yongting Wang, Guo-Yuan Yang, Yijie Chen, Yaohui Tang
Summary: This study develops a biomimetic nanocarrier for precise delivery of human fat extract, which can target damaged and inflamed blood vessels and achieve rapid accumulation in the lesion area of stroke. The nanocarrier can sustainably release the fat extract, promote angiogenesis and neurogenesis, resulting in increased blood flow and neurobehavioral recovery.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke, a common and undertreated cerebral disease with high mortality and disability rate, involves various intrinsic and extrinsic factors that regulate the progression. Astrocytes, as an integral part of the neuronal glia system, play crucial roles in neuronal survival after ischemic stroke. The RhoA/ROCK signaling pathway and astrocytes have significant impact on neurological function and tissue repair after brain injury caused by ischemic stroke.
METABOLIC BRAIN DISEASE
(2021)
Article
Clinical Neurology
Manuela De Michele, Marta Iacobucci, Federica Letteri, Chiara Andreoli, Svetlana Lorenzano, Rossella Canese, Luca Petraglia, Irene Berto, Oscar Gaetano Schiavo, Claudio Di Biasi, Danilo Toni
Summary: The study identified a 1.28-ppm peak possibly indicating neural progenitor cells in the post-stroke human brain using magnetic resonance spectroscopy.
NEUROLOGICAL SCIENCES
(2023)
Article
Engineering, Environmental
Shu-yi He, Lin-yu Long, Zhi-cun Wang, Wen-qi Liu, Wen Zhang, Cheng Hu, Xiao-feng Wu, Ruiqi Dong, Hong-song Fan, Qing Jiang, Ying-ying Tong, Guang-hua Yang, Li Yang, Yun-bing Wang
Summary: In this study, an injectable self-doping conductive hydrogel was developed for delivering human umbilical cord mesenchymal stem cell secretome to protect cardiac function after myocardial infarction. The conductive hydrogel showed good biocompatibility and conductivity consistent with the natural myocardium, and the secretome was able to promote cell proliferation, migration, and angiogenesis. In a rat MI model, hydrogel injection improved ejection fraction and fraction shortening, and decreased susceptibility to arrhythmia.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jiyu Li, Chun Li, Pushpa Subedi, Xinli Tian, Xiaohong Lu, Sumitra Miriyala, Manikandan Panchatcharam, Hong Sun
Summary: Ischemic stroke is a major cause of death and disability globally, and neurogenesis plays a crucial role in post-stroke functional recovery. Alcohol consumption has a dose-dependent effect on the prognosis of ischemic stroke. The study found that light alcohol consumption can promote neurogenesis, reduce brain damage, and improve locomotor activity in mice.
Article
Materials Science, Multidisciplinary
Hongfei Ge, Quan Hu, Tunan Chen, Yang Yang, Chao Zhang, Jun Zhong, Yi Yin, Xuheng Jiang, Xin Zhou, Shuhong Wang, Rong Hu, Wenyan Li, Hua Feng
Summary: A feasible method for modifying grafted neural stem cells (NSCs) using layer-by-layer (LbL) assembly has been developed, which enhances their regenerative ability and survival rate, showing potential application in the treatment of ischemic stroke.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Tingkui Zhao, Fujin He, Keqing Zhao, Lin Yuxia, Huanyu Li, Xingru Liu, Juan Cen, Shaofeng Duan
Summary: Changes in the cerebral microenvironment after acute ischemic stroke-reperfusion hinder neurological function recovery and contribute to stroke recurrence. A triple-targeted self-assembled nanodelivery system was developed, incorporating the neuroprotective drug rutin and hyaluronic acid, along with SS-31 peptide to target mitochondria. This system effectively enhanced plasticity, reduced neurological damage, and promoted neuroinflammation maintenance, penumbra angiogenesis, and neovascularization.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Medicinal
Rengong Zhuo, Zhengmao Song, Yun Wang, Maoshu Zhu, Feng Liu, Pingli Lin, Rong Rao, Yu Zhou, Yun Zhao, Zhongxiong Fan, Lishan Cui, Hongtao Liu, Jingwen Li, Ying Li, Han Guo, Cheng Fu Cai, Lichao Yang
Summary: This study reveals that OEA promotes angiogenesis, neurogenesis, and white matter repair after stroke, leading to improved motor function recovery.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Haihong Jiang, Chao Qin, Daobin Cheng, Qiuhong Lu, Gelun Huang, Dacheng Wang, Hong Yang, Zhijian Liang
MEDICAL SCIENCE MONITOR
(2017)
Article
Medicine, Research & Experimental
Yayuan Liu, Li Chen, Jinseng Zeng, Wenmei Li, Sudan Zeng, Bin Ye, Zhijian Liang
MEDICAL SCIENCE MONITOR
(2018)
Article
Geriatrics & Gerontology
Donghua Zou, Chunbin Liu, Qian Zhang, Xianfeng Li, Gang Qin, Qi Huang, Youshi Meng, Li Chen, Jinru Wei
CLINICAL INTERVENTIONS IN AGING
(2018)
Article
Gastroenterology & Hepatology
Qi-Xiong Qin, Xue-Min Cheng, Li-Zhi Lu, Yun-Fei Wei, Da-Cheng Wang, Hai-Hua Li, Guo-Hui Li, Hong-Bin Liang, Sheng-Yu Li, Li Chen, Zhi-Jian Liang
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Medicine, Research & Experimental
Mengqi Yang, Xueying Pan, Zhijian Clang, Xiaoqin Huang, Meiyi Duan, Hui Cai, Lixia Yu, Li Chen
MEDICAL SCIENCE MONITOR
(2019)
Article
Medicine, General & Internal
Ziqiang Xian, Yicong Chen, Li Chen, Qiuhong Lu, Gelun Huang, Qixiong Qin, Jinsheng Zeng, Zhijian Liang
Article
Medicine, General & Internal
Kemin Qin, Yicong Chen, Haiyin Long, Jiyun Chen, Dacheng Wang, Li Chen, Zhijian Liang
Article
Peripheral Vascular Disease
Mengqi Yang, Xueying Pan, Zhijian Liang, Xiaoqin Huang, Meiyi Duan, Hui Cai, Guimiao Jiang, Xianlong Wen, Li Chen
HYPERTENSION RESEARCH
(2019)
Article
Clinical Neurology
Qiuhong Lu, Gelun Huang, Li Chen, Wenmei Li, Zhijian Liang
Article
Neurosciences
Xiaoqin Huang, Xiaoting Wang, Mengqi Yang, Xueying Pan, Meiyi Duan, Xianlong Wen, Hui Cai, Guimiao Jiang, Li Chen
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Clinical Neurology
Guimiao Jiang, Hui Cai, Xianlong Wen, Kunfeng Chen, Haicheng Li, Yingdan Zhang, Yue Yang, Jiafeng Chen, Li Chen
Summary: This study assessed the clinical characteristics and predictors of vascular events occurring within 5 years after intracerebral hemorrhage (ICH) in Chinese patients. The research found that survivors of ICH are at high risk of both cardiovascular and cerebrovascular events, particularly within the first three years after the initial ICH. Age >56 years and history of ischemic stroke or transient ischemic attack (TIA) were identified as predictors of cardiovascular and cerebrovascular events.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Ming-Jie Li, Shi-Bai Yan, Gang Chen, Guo-Sheng Li, Yue Yang, Tao Wei, De-Shen He, Zhen Yang, Geng-Yu Cen, Jun Wang, Liu-Yu Liu, Zhi-Jian Liang, Li Chen, Bin-Tong Yin, Ruo-Xiang Xu, Zhi-Guang Huang
Summary: The study demonstrates the up-regulation of CCNB2 in lung cancer and cerebral ischemic stroke (CIS), indicating its involvement in the formation of CIS and tissue damage caused by CIS. Furthermore, CCNB2 was found to be up-regulated in GABAergic neurons in brain organoids and T cells expressing proliferative molecules, suggesting its role in neuron repair and cell proliferation.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Review
Neurosciences
Jiafeng Chen, Lijuan Huang, Yue Yang, Wei Xu, Qingchun Qin, Rongxing Qin, Xiaojun Liang, Xinyu Lai, Xiaoying Huang, Minshan Xie, Li Chen
Summary: Nervous system diseases pose challenges to neuroscience research due to limited access to research materials. Somatic cell reprogramming offers a novel approach to obtain neurons. This review provides an overview of the techniques involved in somatic cell reprogramming for neurological research and therapy.
Article
Neurosciences
Xiaoting Wang, Xiaoqin Huang, Mengqi Yang, Xueying Pan, Meiyi Duan, Hui Cai, Guimiao Jiang, Xianlong Wen, Donghua Zou, Li Chen
TRANSLATIONAL NEUROSCIENCE
(2020)