Article
Cell Biology
Yatao Liu, Wei Liu, Xiao-Qing Wang, Zhan-Hai Wan, Yong-Qiang Liu, Meng-Jie Zhang
Summary: This study demonstrates that dexmedetomidine alleviates neuropathic pain in chronic constriction injury (CCI) rats by inhibiting the Keap1-Nrf2-HO-1 pathway-related antioxidant response, inflammation, and apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Runan Yang, Zijing Li, Yuting Zou, Jingjian Yang, Lin Li, Xiumei Xu, Guenther Schmalzing, Hong Nie, Guilin Li, Shuangmei Liu, Shangdong Liang, Changshui Xu
Summary: The study reveals that gallic acid alleviates neuropathic pain in CCI rats by inhibiting the activation of the P2X7 receptor and subsequent signaling pathways, showing potential as a therapeutic agent for neuropathic pain.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ahmed I. Foudah, Mohammed H. Alqarni, Sushma Devi, Akanksha Singh, Aftab Alam, Pravej Alam, Sima Singh
Summary: This study demonstrates that catechin has neuroprotective activity in the chronic constriction injury (CCI) model and can reduce mechanical allodynia and thermal hyperalgesia. Additionally, the analgesic effect of catechin may be related to the expressions of TNF-alpha, IL-6, and IL-beta. Therefore, catechin shows promising potential in the treatment and management of neuropathic pain by decreasing the levels of NF-kappa beta-regulated inflammatory cytokines in the CCI model.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Juping Xing, Hongji Wang, Lisha Chen, Hanxi Wang, Huan Huang, Jiabao Huang, Changshui Xu
Summary: This study investigated the role of Cx43 in neuropathic pain mediated by the P2X4 receptor in rats with chronic constriction injury (CCI). The results showed that blocking Cx43 can alleviate neuropathic pain in CCI rats through the P2X4, p38, ERK, and NF-kB signaling pathways. These findings suggest that Cx43 may be a promising therapeutic target for the development of novel pharmacological agents in the management of neuropathic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Guven Akcay, Dilara Nemutlu Samur, Narin Derin
Summary: tDCS and tsDCS are effective therapies for pain that can alter neuronal activity in the brain and spinal cord. Treatment with tsDCS showed better therapeutic effects on neuropathic pain by regulating oxidant/antioxidant levels and reducing neuroinflammation.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Behavioral Sciences
Nisar Ahmad, Fazal Subhan, Nazar Ul Islam, Muhammad Shahid, Naseem Ullah, Rahim Ullah, Shehla Akbar, Muhammad Usman Amin, Muhammad Khurram, Ihsan Ullah, Robert D. E. Sewell
Summary: In comparison to Gabapentin, the synthesized GABA analogue showed higher efficacy in treating neuropathic pain induced by chronic constriction injury without causing adverse motor effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Hai-Ping You, Chong-Jun Xu, Li-Hong Zhang, Zhi-Yuan Chen, Wei-Feng Liu, Hong-Geng Wang, He-Fan He, Liang-Cheng Zhang
Summary: This study aimed to investigate the effects and mechanisms of Taselisib on neuropathic pain induced by chronic constriction injury in rats. The results showed that Taselisib treatment significantly improved pain behavioral tests, suppressed the upregulation of pro-inflammatory cytokines, and inhibited the PI3K/AKT signaling pathway.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Juan-juan He, Xiao-mei Wei, Meng-li Wu, Zu-biao Song, Li Jiang, Wei-xi Zhang
Summary: This study aimed to investigate the analgesic effect of perineural injection of BoNT/A on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and explore the underlying mechanisms. The results showed that perineural injection of BoNT/A improved the decreased paw mechanical withdrawal threshold (pMWT) and paw thermal withdrawal latency (pTWL) in a CCI rat model. The peripheral analgesic effects were associated with the protection of myelin sheath through inhibiting NLRP3 inflammasome and promoting autophagy flow, while the central analgesic effects were related to inhibiting neuroinflammation and synaptic plasticity in the spinal dorsal horn by inhibiting SNAP-25 and Wnt pathway. This study highlights the potential of perineural injection of BoNT/A as a new treatment for neuropathic pain.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Meng-Yin Yang, Hung-Chuan Pan
Summary: Neuropathic pain is reduced by AhR activation and aggravated by AhR deletion, indicating the neuroprotective effects of AhR. AhR expression is increased after nerve injury, and AhR agonist omeprazole attenuates nerve damage and inflammation. AhR agonists may have potential in neuropathic pain treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiao-Min Zhang, Ming-Hui Lun, Wei Du, Fang Ma, Ze-Qing Huang
Summary: This study observed the ameliorative effect of a kappa opioid receptor (KOR) agonist on rats with neuropathic pain (NP) and investigated the mechanism of action involving the calcium ion (Ca2+)/calcium/calmodulin-dependent protein kinase II (CaMKII)/cyclic AMP response element binding protein (CREB) pathway. The KOR agonist improved the pain thresholds of the NP rats, inhibited inflammatory responses, and relieved oxidative stress injury. It achieved its effects by suppressing the activity of the Ca2+/CaMKII/CREB pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Plant Sciences
Kuang- Cheng, Sin-Lan Chen, Jong-Hau Hsu, Yu-Chi Cheng, Yu-Chin Chang, Chien-Hsing Lee, Jwu-Lai Yeh, Zen-Kong Dai, Bin-Nan Wu
Summary: The study demonstrated that loganin attenuates neuropathic pain induced by CCI by suppressing CXCL12/CXCR4-mediated NLRP3 inflammasome activation, thereby improving mechanical allodynia and thermal hyperalgesia.
Article
Biochemistry & Molecular Biology
Ximei Wang, Yuan Jiang, Jingyi Li, Yunjiao Wang, Ying Tian, Qulian Guo, Zhigang Cheng
Summary: Shifting microglial polarization from M1 to M2 phenotype by DUSP1 in the medial prefrontal cortex attenuated neuropathic pain induced by chronic constriction injury through inhibition of MAPK signaling.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Mengke Wang, Xia Cai, Yueying Wang, Shizhen Li, Na Wang, Rui Sun, Jingming Xing, Shangdong Liang, Shuangmei Liu
Summary: The study showed that astragalin can alleviate neuropathic pain by inhibiting the activation of P2X4 and satellite glial cells in the dorsal root ganglia, indicating its therapeutic potential for clinical pain management.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Weiguang Zhang, Fei Wang, Licai Zhang, Tao Sun, Zhijian Fu
Summary: The study revealed that ozone may alleviate neuropathic pain in rats with chronic constriction injury of the sciatic nerve by modulating the spinal GluR6-NF-kappa B/p65 signaling pathway. Additionally, ozone was found to inhibit pain behaviors and suppress the expression of spinal inflammatory mediators, indicating its potential as a therapeutic intervention for neuropathic pain.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Ting Zhang, Run Zhang, Biao Xu, Mengna Zhang, Qinqin Zhang, Ning Li, Yu Qiu, Dan Chen, Kangtai Xu, Jian Xiao, Nan Zhang, Quan Fang
Summary: The study showed that endomorphins can alleviate burn-induced pain through the μ-opioid receptor by affecting the activation of spinal p38 MAPK pathway. This provides a new perspective for pain treatment research.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Orthopedics
Siyuan Zhu, Xinning Li, Jia-Lin Wu, Lei Bao, Peng Wang, Haifeng Gu, Chenglong Wang, Jianhua Wang
Summary: The study described a non-anatomic arthroscopic all-inside repair technique for medial meniscus posterior root tears in middle-aged and older patients, showing good clinical outcomes and structural healing. The method was effective in treating MMPRTs in this patient population as an alternative to the transtibial pullout repair technique.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Xiaolin Xu, Chenglong Wang, Peipei Zhang, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Jia Yuan, Hongjing Dou, Guoxiong Xu
Summary: This study reveals that chemoresistant cancer cells show decreased ROS levels and increased oxidative phosphorylation. Chemoresistant cells generate more energy through oxidative phosphorylation and enhance ROS scavenging systems to resist the effects of chemotherapy. Furthermore, increased ROS production efficiently inhibits chemoresistance and promotes cell death in chemoresistant cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Orthopedics
Chenglong Wang, Liqiang Cui, Qinwen Gu, Sheng Guo, Bin Zhu, Xueli Liu, Yujie Li, Xinyue Liu, Dingxuan Wang, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a common cause of low back pain, and its pathological mechanism involves complex genetic, developmental, biochemical, and biomechanical factors. Non-coding RNA, especially miRNA, has been found to play a crucial role in the development of IDD through various cellular and molecular processes. However, there is still a lack of effective non-surgical treatment options for IDD.
ORTHOPAEDIC SURGERY
(2022)
Article
Integrative & Complementary Medicine
Joon-Ho Lee, Yuan-Ji Wei, Zhong-Yan Zhou, Yu-Ming Hou, Cheng-Long Wang, Li-Bo Wang, Hong-Jin Wu, Yu Zhang, Wei-Wei Dai
Summary: The herbal pair of Radix Achyranthis Bidentatae and Eucommiae Cortex can ameliorate the effects of glucocorticoid-induced osteoporosis in zebrafish, with a 1:1 dosage ratio being the most effective.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Geriatrics & Gerontology
Chenglong Wang, Sheng Guo, Qinwen Gu, Xiaoqiang Wang, Longhai Long, Changming Xiao, Mingzhong Xie, Huarui Shen, Sen Li
Summary: Low back pain is a global problem, and intervertebral disc degeneration is often considered as its main cause. Current treatment methods cannot restore the normal structure of the intervertebral disc. Exosomes, as active biological substances for promoting tissue regeneration, have shown potential in the treatment of IDD.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Cell Biology
Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li
Summary: This article discusses the diverse role of transforming growth factor-beta (TGF-beta) in tendon injuries and its regulation of tendon repair through both the Smad and non-Smad signaling pathways.
Article
Nanoscience & Nanotechnology
Hui-Jun Fu, Lin Luo, Yu Wang, Cheng-Long Wang, Hong Wang, Yu-Dong Shen, Hong-Tao Lei, Niko Hildebrandt, Zhen-Lin Xu
Summary: This study developed a monoclonal antibody against XAA and established a competitive enzyme-linked immunosorbent assay (ELISA) based on the multicolor detection of gold nanorods (AuNRs), with a broad linear range, low limit of detection, and a 3.6-fold sensitivity improvement compared to conventional tetramethylbenzidine-based ELISA. The rapid and simple color analysis showed a strong potential for implementation into direct consumer product testing.
ACS APPLIED NANO MATERIALS
(2022)
Review
Physiology
Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a complex skeletal disease involving multiple factors. The piezo1 ion channel has been identified as a critical factor in the pathogenesis of IDD. Inactivating or interfering with the piezo1 channel can effectively prevent the progression of IDD.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Review
Chemistry, Medicinal
Longhai Long, Xiaoqiang Wang, Yang Lei, Sheng Guo, Chenglong Wang, Wenbin Dai, Birong Lin, Mingzhong Xie, Houping Xu, Sen Li
Summary: Osteoporosis is a metabolic skeletal disorder characterized by reduced bone mineral density and microstructural destruction, leading to increased fracture risk. Current medicines have limitations and potential side effects, prompting the search for natural alternatives. Icariin, derived from a traditional Chinese medicine, has shown promise in reducing bone loss in osteoporosis with relatively low side effects. It acts through various mechanisms, including promoting bone formation and suppressing bone resorption. While the underlying mechanisms are not fully understood, icariin could be a viable option for improving osteoporosis.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Review
Geriatrics & Gerontology
Hongyu Pan, Hongtao Li, Sheng Guo, Chenglong Wang, Xiaoqiang Wang, Houyin Shi, Kaiquan Zhang, Hui Chen, Sen Li
Summary: Low back pain (LBP) is a common health problem caused by intervertebral disc degeneration (IDD), which is mainly attributed to aging, mechanical stress, and lack of nutrition. The pathological mechanism of IDD is complex, involving inflammatory response and cell metabolism disorder. Tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in IDD by promoting extracellular matrix degradation and inflammatory responses. Anti-TNF-alpha therapy is an effective treatment for alleviating IDD.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Geriatrics & Gerontology
Hongtao Li, Xiaoqiang Wang, Hongyu Pan, Changming Xiao, Chenglong Wang, Sheng Guo, Longhai Long, Houyin Shi, Hui Chen, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP) and disability in the elderly, resulting in a significant global public health and economic burden. The mechanisms of IDD are complex and the specific targets for reversing IDD remain unclear. Interleukin-1 beta (IL-1 beta), a key mediator of IDD, has been found to regulate IVD cell death through various mechanisms, including apoptosis, pyroptosis, and ferroptosis. Inhibition of IL-1 beta has shown promise as a biological therapy for IDD by inhibiting inflammatory processes and regulating ECM degradation. This article reviews the mechanisms and functions of IL-1 beta in IDD and explores advances in IL-1 beta inhibition as a potential biotherapeutic approach for disc degeneration.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Acoustics
Yujie Li, Wei Li, Xinyue Liu, Xueli Liu, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li, Zhongfa Zhang
Summary: Tendon injuries are common soft tissue injuries caused by overuse and degeneration. Tendon repair is slow and inefficient due to the lack of cellular structure and blood vessels. Low-intensity pulsed ultrasound (LIPUS) is a promising non-invasive method for promoting tendon healing. This review examines studies on LIPUS and summarizes its effects on tendon injury, with 87.5% of studies showing improvement. Further research on the application of LIPUS in tendon diseases is warranted.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Orthopedics
Shanjun Huang, Yujiao Liu, Chenglong Wang, Wei Xiang, Nianwu Wang, Li Peng, Xuanang Jiang, Xiaomin Zhang, Zhijiang Fu
Summary: Osteoarthritis (OA) is a debilitating disease with significant economic and social burden. Cartilage injury, characterized by excessive chondrocyte death, inflammation, abnormal bone metabolism, and imbalance of extracellular matrix, presents a major pathological feature of OA. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) have shown promise as both early diagnostic biomarkers and therapeutic strategies for OA, due to their important role in intercellular communication. This paper comprehensively reviews the functions and mechanisms of MSCs-EVs in cartilage repair, highlighting their potential in protecting chondrocyte death, regulating bone metabolism, balancing extracellular matrix metabolism, alleviating inflammation, and regulating angiogenesis.
ORTHOPAEDIC SURGERY
(2023)
Article
Geochemistry & Geophysics
Jie Nie, Chengyu Zheng, Chenglong Wang, Zijie Zuo, Xiaowei Lv, Shusong Yu, Zhiqiang Wei
Summary: In this paper, a scale-relation joint decoupling network (SRJDN) is proposed for the semantic segmentation of remote sensing (RS) images, which considers decoupling scales and decoupling relationships to explore more complete relationships of multiscale RS objects. The SRJDN consists of three steps: scale decoupling (SD), relation decoupling (RD), and fine-granularity guided fusion (FGF). Experimental results on two large-scale fine-resolution RS image datasets demonstrate the effectiveness and robustness of the proposed joint decoupling strategy and the FGF module in RS image semantic segmentation tasks.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Computer Science, Information Systems
Jingyu Wang, Chenglong Wang, Qicheng Yang, Chengyu Zheng, Jie Nie, Mingxing Jiang
Summary: In this paper, a Bidirectional Macro-Micro Adaptive Enhancement (BMMAEnet) framework is proposed for the re-colorization of remote sensing images. The framework consists of three modules: the Downward Micro Enhancement (DME) module, the Upward Adaptive Macro Enhancement (UAME) module, and the Macro-Micro Balance (MMB) module. Experimental results show that the proposed method outperforms other methods in terms of pixel color value restoration performance and human perceptive understanding.
