Article
Clinical Neurology
Jahrane Dale, Stephen L. Schmidt, Kyle Mitchell, Dennis A. Turner, Warren M. Grill
Summary: This review describes the general features, mechanisms, technical recording factors, and clinical applications of brain evoked potentials (EPs) generated by deep brain stimulation (DBS) for Parkinson's disease (PD). DBS-evoked potentials arise from a complex integration of antidromic and orthodromic conduction pathway responses and provide valuable information for understanding the mechanisms and circuits involved in symptom treatment. These signals may serve as biomarkers for improving DBS outcomes and function. However, there are still critical gaps in our understanding of the mechanisms and clinical application of DBS-induced EPs.
Article
Neurosciences
Natasha Darcy, Roxanne Lofredi, Bassam Al-Fatly, Wolf-Julian Neumann, Julius Huebl, Christof Bruecke, Patricia Krause, Gerd-Helge Schneider, Andrea Kuehn
Summary: This report provides robust evidence that spectral peaks in the beta frequency range can be detected in the majority of subthalamic nuclei in Parkinson's disease patients, increasing confidence in the broad applicability of beta-guided deep brain stimulation.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Peter Kempster, Andrew Ma
Summary: A large proportion of drugs for neurological disorders are derived from naturally occurring compounds, especially plant alkaloids. The treatment of Parkinson's disease has strong botanical origins, with plant-derived substances playing a significant role. The interaction between plant compounds and animal dopaminergic systems has deep evolutionary roots.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Ritesh A. Ramdhani, Jeremy Watts, Myriam Kline, Toni Fitzpatrick, Martin Niethammer, Anahita Khojandi
Summary: This study investigated the effects of high-frequency and low-frequency STN-DBS on spatiotemporal gait kinematics in patients with advanced Parkinson's disease. It was found that high-frequency STN-DBS significantly improved trunk and lumbar kinematics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Ramon Cacabelos, Ivan Carrera, Olaia Martinez, Ramon Alejo, Lucia Fernandez-Novoa, Pablo Cacabelos, Lola Corzo, Susana Rodriguez, Margarita Alcaraz, Laura Nebril, Ivan Tellado, Natalia Cacabelos, Rocio Pego, Vinogran Naidoo, Juan C. Carril
Summary: Atremorine is a novel bioproduct obtained from a genetic species of Vicia faba, acting as a potent dopamine enhancer and neuroprotective agent in Parkinson's disease. It enhances dopamine levels, influences other neurotransmitters and hormones, and potentiates the effects of conventional anti-PD drugs. The variability in response to Atremorine is highly influenced by pharmacogenetic factors, polymorphic gene variants, and its ability to modulate the pharmacoepigenetic network.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Abhishek Kumar Mishra, Anubhuti Dixit
Summary: Parkinson's disease is characterized by the depletion of dopamine in the striatum due to the loss of nigrostriatal dopaminergic neurons, leading to motor dysfunction and other clinical symptoms. Protecting the substantia nigra neurons is crucial for maintaining dopamine levels. Current strategies for treating PD focus on preventing cell body death but new approaches may target axonal degeneration to prevent loss of synaptic terminals and alleviate symptomatic features.
NEUROCHEMICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
J. Brucker Nourse, Shannon N. Russell, Nathan A. Moniz, Kylie Peter, Lena M. Seyfarth, Madison Scott, Han-A Park, Kim A. Caldwell, Guy A. Caldwell
Summary: This study investigates the TNK2 gene variants in Parkinson's disease (PD) patients and their potential impact on dopaminergic neurodegeneration. The findings suggest that TNK2 dysfunction may contribute to PD, possibly through sustained or aberrant activity. The study also highlights the importance of TNK2 and its ortholog SID-3 in coordinating dopaminergic and epigenetic signaling. Experimental results using Caenorhabditis elegans and rat primary neurons demonstrate the neuroprotective effects of TNK2 inhibition and NEDD4 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Abhimanyu Mahajan, Ankur Butala, Michael S. Okun, Zoltan Mari, Kelly A. Mills
Summary: The study revealed a high variability in approaches for DBS candidate selection, brain target selection, procedure type, and postoperative practices. Cognitive and mood assessments were underutilized and there was low reliance on multidisciplinary teams or psychosocial factors in the decision-making process. Prospective studies are needed to inform evidence-based guidelines.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Somnath Das, Caio M. Matias, Sunidhi Ramesh, Lohit Velagapudi, Julie P. Barbera, Samantha Katz, Michael P. Baldassari, Mohammad Rasool, Daniel Kremens, Jeffrey Ratliff, Tsao-Wei Liang, Chengyuan Wu
Summary: PD patients seen at an urban movement disorders clinic expressed concerns regarding the efficacy, invasiveness, cost, and irreversibility of DBS, independent of the original source of information. Most patients considered DBS to be an effective treatment for PD, but were also worried about potential negative effects of the surgery.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Nico Golfre Andreasi, Luigi Michele Romito, Roberta Telese, Roberto Cilia, Antonio Emanuele Elia, Alessio Novelli, Giovanni Tringali, Giuseppe Messina, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Angelo Amato Franzini, Roberto Eleopra
Summary: STN-DBS has a long-lasting effect on motor complications in both male and female PD patients, but there may be slight differences in certain aspects that require further investigation.
NEUROLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shigeki Hirano
Summary: Evidence from dopaminergic imaging and cerebral blood flow/metabolism images has provided insights into the cognitive symptoms of healthy individuals and Parkinson's disease patients. Cognitive impairment in Parkinson's disease is characterized by executive, visuospatial, and attentional disturbances. The dopaminergic system consists of three parallel pathways, each responsible for different functions and affected by dopamine levels.
MOLECULAR MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Wen Jing, Zhang Yuan-Qiang, Liu Dong-Qing, Yao Xu-Tao, Jiang Hua, Zhang Yu-Bin
Summary: This study aimed to explore the neuroprotective effects and pharmacological mechanism of Demethylenetetrahydroberberine (DMTHB) on Parkinson's disease. The results showed that DMTHB could alleviate behavioral disorders, protect dopaminergic neurons, and exhibit multiple-target effects including anti-apoptotic, anti-inflammatory, and antioxidant properties.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Clinical Neurology
Hana Brozova, Isabelle Barnaure, Evzen Ruzicka, Jan Stochl, Ron Alterman, Michele Tagliati
Summary: The study aimed to compare the short and long-term effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on gait dysfunction and other cardinal symptoms of Parkinson's disease (PD). The results showed that short-term improvement of gait abnormalities appears to significantly decline after 5 years of STN DBS in PD patients, while effectiveness for other symptoms remains stable. This suggests that non-dopaminergic mechanisms or deleterious effects of high frequency STN stimulation might play a role in the decline of gait function over time.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Amer Jaradat, Andreas Nowacki, Matteo Montalbetti, Ines Debove, Katrin Petermann, Janine -Ai Schlaeppi, Lenard Lachenmayer, Gerd Tinkhauser, Paul Krack, Thuy-Anh Khoa Nguyen, Claudio Pollo
Summary: This study integrated a previously validated probabilistic STN sweet spot into a commercially available software to evaluate its predictive value for clinically effective DBS programming in patients with Parkinson disease. The results showed a certain level of match between the image-based prediction and clinical evaluation in terms of stimulation effect and side-effect thresholds, indicating the potential of this integrated image-based programming approach in optimizing DBS programming for PD patients.
Article
Medicine, Research & Experimental
Ashesh Shah, Thuy-Anh Khoa Nguyen, Katrin Peterman, Saed Khawaldeh, Ines Debove, Syed Ahmar Shah, Flavie Torrecillos, Huiling Tan, Alek Pogosyan, Martin Lenard Lachenmayer, Joan Michelis, Peter Brown, Claudio Pollo, Paul Krack, Andreas Nowacki, Gerd Tinkhauser
Summary: In this study, the advantage of algorithmic selection and combination of multiple electrophysiological and imaging markers is investigated to predict relevant clinical deep brain stimulation (DBS) parameters. The results show that the combination of resting and movement-state features from multiple frequency bands can accurately predict the clinical outcome of DBS treatment. The use of both electrophysiological and imaging markers improves the prediction accuracy.
Article
Clinical Neurology
Katina Aleksovska, Claudio L. A. Bassetti, Thomas Berger, Vanessa Carvalho, Joao Costa, Guenther Deuschl, Kristian S. Frederiksen, Joke Jaarsma, Teia Kobulashvili, Maurizio Leone, Lucia Pavlakova, Michele Romoli, Luca Vignatelli
Summary: This paper aims to establish a set of criteria for prioritizing topics for future European Academy of Neurology (EAN) guidelines. Through literature review, a Delphi consensus procedure, and voting, a set of approved criteria were determined, and the first 30 topics were selected. The process involved both a bottom-up approach with community involvement and a top-down approach with board member selection.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Conor Fearon, Arun E. Sundaram, Renato P. Munhoz, Alfonso Fasano, Felix Tyndel
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Serge Pinto, Adelheid Nebel, Jorn Rau, Robert Espesser, Pauline Maillochon, Oliver Niebuhr, Paul Krack, Tatiana Witjas, Alain Ghio, Marie-Charlotte Cuartero, Lars Timmermann, Alfons Schnitzler, Helke Hesekamp, Niklaus Meier, Julia Muellner, Thomas D. Haelbig, Bettina Moeller, Steffen Paschen, Laura Paschen, Jens Volkmann, Michael T. Barbe, Gereon R. Fink, Johannes Becker, Paul Reker, Andrea A. Kuehn, Gerd-Helge Schneider, Valerie Fraix, Eric Seigneuret, Andrea Kistner, Olivier Rascol, Christine Brefel-Courbon, Fabienne Ory-Magne, Christian J. Hartmann, Lars Wojtecki, Anne Fradet, David Maltete, Philippe Damier, Severine Le Dily, Friederike Sixel-Doering, Petra Benecke, Daniel Weiss, Tobias Waechter, Marcus O. Pinsker, Jean Regis, Stephane Thobois, Gustavo Polo, Jean-Luc Houeto, Andreas Hartmann, Karina Knudsen, Marie Vidailhet, Michael Schuepbach, Gunther Deuschl
Summary: This study compared speech intelligibility assessment and other outcomes between subthalamic nucleus deep brain stimulation (STN-DBS) and best medical treatment (BMT) in early-stage Parkinson's disease patients over a 2-year period. The results showed no significant differences in speech intelligibility and patient-reported outcomes between the STN-DBS and BMT groups, but there was a trend towards worsening in both groups.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Robin Wolke, Olga Gavriliuc, Oliver Granert, Guenther Deuschl, Nils G. Margraf
Summary: Using computer vision technology, 3D human body models are generated from regular photographs to evaluate postural disorders. The accuracy and applicability of this method are validated by comparing with the gold standard. The generated 3D models are not affected by the camera angle and provide a comprehensive analysis.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Alfonso Fasano, Rocio Garcia-Ramos, Tanya Gurevich, Robert Jech, Lars Bergmann, Olga Sanchez-Solino, Juan Carlos Parra, Mihaela Simu
Summary: A multinational retrospective study found that long-term use of levodopa-carbidopa intestinal gel (LCIG) can improve motor and nonmotor symptoms in patients with Parkinson's disease, while potentially reducing the need for additional medications.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Matteo Bologna, Alberto J. Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Jinyoung Youn, Carolina Gorodetsky, Andres M. Lozano, Anthony E. Lang, Alfonso Fasano
Summary: Despite no previous reports on parkinsonism in Poland syndrome (PS) and the lack of studies on treatment response, we present a case of ipsilateral parkinsonism in PS, resembling hemiatrophy-hemiparkinsonism, with a positive response to levodopa and subthalamic deep brain stimulation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Multidisciplinary Sciences
Sabrina Schlienger, Patricia T. Yam, Nursen Balekoglu, Hugo Ducuing, Jean-Francois Michaud, Shirin Makihara, Daniel K. Kramer, Baoyu Chen, Alfonso Fasano, Alfredo Berardelli, Fadi F. Hamdan, Guy A. Rouleau, Myriam Srour, Frederic Charron
Summary: Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. In this study, we identified ARHGEF7 as a candidate MM gene and demonstrated its role in Netrin-1-mediated axon guidance. We further showed that Arhgef7/Git1 acts as a multifunctional effector complex, activating Rac1 and Cdc42 and inhibiting Arf1 downstream of Netrin-1.
Review
Clinical Neurology
Massimiliano Passaretti, Alessio Maranzano, Brent Bluett, Rajasumi Rajalingam, Alfonso Fasano
Summary: Gait analysis is a reliable tool to assess gait impairment in iNPH patients. Gait parameters improve after tap-test and CSF shunt surgery, but do not completely normalize. Tap-test's effect on gait velocity reaches its peak after 24-48 hours and returns to baseline after 90-100 hours.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Health Care Sciences & Services
Michael Single, Lena C. Bruhin, Narayan Schuetz, Aileen C. Naef, Heinz Hegi, Pascal Reuse, Kaspar A. Schindler, Paul Krack, Roland Wiest, Andrew Chan, Tobias Nef, Stephan M. Gerber
Summary: This paper presents the development of a novel sensor recording software system that supports the integration of heterogeneous sensor technologies and can reliably record longitudinal sensor measurements in research settings. Through qualitative and quantitative tests and evaluations, the feasibility and reliability of the software system were demonstrated. Conclusion: This software can be used to test sensor devices, develop and validate algorithms for extracting digital measures, and reduce barriers in sensor-enhanced biomedical research.
JMIR FORMATIVE RESEARCH
(2023)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Robin Wolke, Jos Steffen Becktepe, Steffen Paschen, Ann-Kristin Helmers, Dorothee Kuebler-Weller, Jinyoung Youn, Dana Brinker, Hagai Bergman, Andrea A. Kuehn, Alfonso Fasano, Guenther Deuschl
Summary: The efficacy of deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease varies among patients. The levodopa challenge can be used to predict individual responses, but its accuracy is limited.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)