Diarylethene‐Based Photoswitchable Inhibitors of Serine Proteases

PHOTACs enable optical control of protein degradation

(2020) Martin Reynders et al.   Science Advances

Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides

(2020) Andrew M. White et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility

(2020) Christoph W. Grathwol et al.   ChemMedChem

Sunflower Trypsin Inhibitor‐1 (SFTI‐1): Sowing Seeds in the Fields of Chemistry and Biology

(2020) Simon J de Veer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoproteomics‐Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism

(2020) Brendan Dwyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase

(2020) Nadja A. Simeth et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent implementations of molecular photoswitches into smart materials and biological systems.

(2019) Zbigniew Pianowski   CHEMISTRY-A EUROPEAN JOURNAL

Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3

(2019) Sixin Tian et al.   ACS Medicinal Chemistry Letters

Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs

(2019) Patrick Pfaff et al.   ACS Central Science

Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand

(2018) Andrea C. Kneuttinger et al.   CHEMBIOCHEM

In Vivo Photopharmacology

(2018) Katharina Hüll et al.   CHEMICAL REVIEWS

Efficiently Photocontrollable or Not? Biological Activity of Photoisomerizable Diarylethenes

(2018) Igor V. Komarov et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photochromic Indolyl Fulgimides as Chromo-pharmacophores Targeting Sirtuins

(2018) Nadja A. Simeth et al.   JOURNAL OF ORGANIC CHEMISTRY

The Endeavor of Diarylethenes: New Structures, High Performance, and Bright Future

(2018) Junji Zhang et al.   Advanced Optical Materials

Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold

(2017) Joakim E. Swedberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen-Dependent Photodynamic Cancer Therapy

(2016) Oleg Babii et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors

(2015) Heiko Fittler et al.   CHEMBIOCHEM

Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy

(2015) Wiktor Szymanski et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl–Prolyl Isomerase Pin1

(2015) Bisheng Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling Biological Activity with Light: Diarylethene-Containing Cyclic Peptidomimetics

(2014) Oleg Babii et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteasome Inhibitors with Photocontrolled Activity

(2014) Mickel J. Hansen et al.   CHEMBIOCHEM

Cell-Permeable Bicyclic Peptide Inhibitors against Intracellular Proteins

(2014) Wenlong Lian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photopharmacology: Beyond Proof of Principle

(2014) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

(2014) C. Falenczyk et al.   Chemical Science

Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties

(2013) Xiangguo (Eric) Shi et al.   ANALYTICAL CHEMISTRY

Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors

(2013) Bernd Reisinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

(2013) Wiktor Szymański et al.   CHEMICAL REVIEWS

High-affinity Cyclic Peptide Matriptase Inhibitors

(2013) Pedro Quimbar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria

(2012) Inês M. Torcato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The pharmacological landscape and therapeutic potential of serine hydrolases

(2012) Daniel A. Bachovchin et al.   NATURE REVIEWS DRUG DISCOVERY

“Triazole Bridge”: Disulfide-Bond Replacement by Ruthenium-Catalyzed Formation of 1,5-Disubstituted 1,2,3-Triazoles

(2011) Martin Empting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network

(2011) Joakim E. Swedberg et al.   PLoS One

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases

(2010) Anna Łęgowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sunflower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs

(2010) Michelle L. Colgrave et al.   BIOPOLYMERS

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-α-dithienylethene derivatives

(2009) Daniel Vomasta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor

(2008) Daniel Vomasta et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION