Article
Chemistry, Multidisciplinary
Yuxing Ji, Yanan Pan, Xuemei Ma, Yan Ma, Zhongxiang Zhao, Qiang He
Summary: In this study, a glucose-powered Janus nanomotor that can drive motion through a glucose concentration gradient generated by enzymatic reaction has been proposed. It shows promising capabilities for the delivery of Fe ions and generation of H2O2, which are important for cancer treatment.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
F. Ouyang, L. Zhang, Y. Liu, Q. Shuai
Summary: In order to improve the delivery of anti-cancer drugs, researchers have developed a multistage gas/enzyme/NIR driven nanorocket for the combination therapy of photodynamic therapy, photothermal therapy, starvation therapy, chemodynamic therapy, and chemotherapy. The nanorocket achieves deep penetration of tumor tissue through a multistage mechanism driven by CO2 gas, enzymes, and CO2/NH3 gas. This approach increases the movement speed and puncture ability of the nanorocket, resulting in improved anticancer efficacy. The use of multistage gas/enzyme/NIR driven chemotactic transport nanorockets opens up new possibilities for deeply penetrating cancer treatment through combination therapy.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ziyu Wu, Min Zhou, Xueting Tang, Jiaqi Zeng, Yazhou Li, Yuning Sun, Jia Huang, Lin Chen, Mimi Wan, Chun Mao
Summary: The study reports a carrier-free nanomotor that utilizes nitric oxide (NO) as a driving force to induce autophagy of macrophages and improve abnormal lipid metabolism in atherosclerosis. The nanomotor achieves precise targeting and high biological availability with the use of trehalose, L-arginine, and phosphatidylserine.
Article
Chemistry, Multidisciplinary
Anshul Dhankher, Wei Lv, William T. Studstill, Julie A. Champion
Summary: This study explores the use of a protein carrier, known as the Hex carrier, to deliver antibodies to therapeutic targets inside cancer cells. Different versions of the carrier were designed to investigate the roles of each building block in cytosolic protein delivery. Results show that the Hex coiled coil, in conjunction with His-tags, could serve as a generalizable vehicle for delivering small and large proteins to intracellular targets, highlighting new biological applications and the impact of histidine residues on endosomal disruption.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Hyunsik Choi, Jeeyoon Yi, Seong Hwi Cho, Sei Kwang Hahn
Summary: Self-propelling micro- and nano-motors are a multifunctional platform for smart healthcare applications, including biosensing, bioimaging, and targeted drug delivery. They can be powered and guided by chemical substances or external stimuli, showing promise for in vivo applications and future clinical use. Despite some limitations, MNMs have the potential to revolutionize diagnostic and therapeutic approaches in healthcare.
Article
Chemistry, Physical
Maria Ortega-Franqueza, Svetlana Ivanova, Maria Isabel Dominguez, Miguel Angel Centeno
Summary: Mesoporous carbonaceous materials were synthesized using nanocasting technique with boehmite as a template and glucose as a carbon precursor. Doping with N, B and K during prepyrolysis impregnation influenced morphology, crystallinity and stability. The phosphorus-doped sample exhibited better oxidation resistance and higher combustion temperature compared to other materials.
Article
Chemistry, Multidisciplinary
Congli Wang, Zhenghan Di, Zhichu Xiang, Jian Zhao, Lele Li
Summary: This study introduces an extremely simple approach for co-delivery of proteins and nucleic acids into cancer cells by one-step, coordination-driven self-assembly, resulting in significant inhibition of tumor growth in vivo. The platform offers efficient co-encapsulation of the two macromolecular components with high loading content and tunable ratios, showing great potential for personalized medicine.
Article
Biochemistry & Molecular Biology
Christopher R. Hango, Coralie M. Backlund, Hazel C. Davis, Nicholas D. Posey, Lisa M. Minter, Gregory N. Tew
Summary: Designing simple block copolypeptides for non-covalent protein delivery based on optimization of polymeric cell-penetrating peptide mimics resulted in carriers with enhanced performance; Carrier hydrophobicity predicts top performers for internalization and activity of protein cargoes, rather than side-chain functionality being the key factor; Concept of intracellular availability (IA) helps understand the physical relationship between cellular internalization and bioavailability, with carriers with maximal IA existing within a narrow hydrophobicity window.
Article
Chemistry, Multidisciplinary
Aristea Anna Leventi, Henry J. Braddick, Kharmen Billimoria, Gregory Q. Wallace, Heidi Goenaga-Infante, Nicholas C. O. Tomkinson, Karen Faulds, Duncan Graham
Summary: This article reports the synthesis of nanocarriers for delivering the antitumor drug cisplatin. Multimodal imaging techniques, including surface enhanced Raman scattering and laser ablation inductively coupled plasma time of flight mass spectrometry, were used to visualize the intracellular uptake of both the nanocarrier and drug.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Jiaoyu Ren, Pengcheng Hu, Enhui Ma, Xiaoyu Zhou, Wenjun Wang, Shaohui Zheng, Hong Wang
Summary: Low cellular uptake and lysosomal degradation are common challenges in cancer drug delivery. In this study, a novel nanomotor was developed to achieve high cell uptake rate and lysosomal escape by self-propulsion under the tumoral endogenous hydrogen peroxide. The nanomotor was constructed using calcium carbonate nanoparticles as the core and polyethyleneimine (PEI) and catalase (CAT) as the shell via layer-by-layer self-assembly technology. The nanomotor was loaded in Schiff-base hydrogel to enable local administration and slow release inside tumors. With the acidic pH and high amount of hydrogen peroxide in the tumor microenvironment, the nanomotors were released from the hydrogel system and autonomously propelled by the generated oxygen gradient. Folic acid (FA) modification on the nanomotors further enhanced the cell uptake rate. Moreover, the nanomotors efficiently escaped from lysosomes and facilitated the delivery of PTX and siRNA to their intracellular target, tubulin, resulting in tumor cell apoptosis. In vitro and in vivo studies demonstrated the excellent antitumor effect of the nanomotor-hydrogel system. Overall, this proposed system provides new insights into drug delivery for cancer treatment.
APPLIED MATERIALS TODAY
(2022)
Article
Polymer Science
Christopher R. Hango, Hazel C. Davis, Esha A. Uddin, Lisa M. Minter, Gregory N. Tew
Summary: Short PTDMs facilitate protein internalization, while longer PTDMs enhance protein activity inside cells without increasing internalization. Longer PTDMs improve the intracellular availability of the cargo, leading to enhanced protein delivery.
Review
Chemistry, Multidisciplinary
Jeongsoo Hur, Aram J. Chung
Summary: This review provides an overview of recent advances in microfluidic and nanofluidic intracellular delivery strategies and discusses new opportunities and challenges for clinical applications. Microfluidic and nanofluidic approaches as emerging solutions have shown remarkable potential for addressing this open challenge.
Article
Engineering, Environmental
Jianye Fu, Jinqing Jiao, Wenhuang Ban, Yueqi Kong, Zhengying Gu, Hao Song, Xiaodan Huang, Yannan Yang, Chengzhong Yu
Summary: The research presents a facile one-step self-assembly strategy for synthesizing shuttlecock-shaped silica nanoparticles, which exhibit asymmetric streamline conical morphology with ultra-large opening and provide superior diffusibility and catalytic performance for nanomotors.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Haofei Zhou, Ye Yuan, Zhexu Wang, Zexin Ren, Mixia Hu, JingKun Lu, Hongxia Gao, Cheng Pan, Wenjie Zhao, Baohua Zhu
Summary: This study has developed a novel nanoplatform for delivering chemotherapy drugs and overcoming multidrug resistance. By using a combination strategy of quercetin and doxorubicin and utilizing the high-speed motion of the motor, this nanoplatform can increase the intracellular accumulation of drugs and enhance the killing effect on multidrug-resistant cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Biomedical
Lisa R. Volpatti, Matthew A. Bochenek, Amanda L. Facklam, Delaney M. Burns, Corina MacIsaac, Alexander Morgart, Benjamin Walters, Robert Langer, Daniel G. Anderson
Summary: This study develops biodegradable, partially oxidized alginate carriers for glucose-responsive insulin delivery and islet cell transplantation therapy. The results demonstrate that these carriers can achieve glycemic control and reduce the volume of nondegradable material implanted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jeong Hun Choi, Nitee Kumari, Jung Hun Koo, Amit Kumar, Changhoon Lee, Ji Hoon Shim, Zhipeng Wang, Sang Ho Oh, In Su Lee
Summary: This study presents a facile method for the synthesis of unconventional amorphous hollow-silica nanostructures with controllable surface curvatures, symmetries, and interior architectures. The key role of transiently in situ crystallized metal coordination complexes as a template is identified for the differential silica growth that produces different nanostructures. Furthermore, crystal-like well-defined polygonal h-SiNSs can be assembled into highly ordered mesoscale materials with customizable cavities and nanospaces, which differ from conventionally assembled materials.
Article
Chemistry, Multidisciplinary
Rui-Yang Wang, Seungwon Jeong, Hyeonseong Ham, Jihoon Kim, Hojun Lee, Chang Yun Son, Moon Jeong Park
Summary: This study presents an innovative electrolyte technology based on a bifunctional polymer to achieve high ionic conductivity in solid-state polymer electrolytes. The addition of an ionic liquid forms interconnected ion channels in the polymeric domains, which accelerates proton transport and improves overall performance.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Amit Kumar, Soumen Dutta, Seonock Kim, Taewan Kwon, Santosh S. Patil, Nitee Kumari, Sampathkumar Jeevanandham, In Su Lee
Summary: Nanomaterials with unique structures and compositions can exhibit exotic physicochemical properties and have various applications. Solid-state reaction synthesis offers potential for scalable access to a wide range of crystal phases and intricate compositions. However, controlling nanoscale features through solid-state reactions requires a strategic nanospace-confinement approach to avoid heat-induced reshaping and sintering.
Article
Chemistry, Multidisciplinary
Jongwon Lim, Nitee Kumari, Trimbak B. Mete, Amit Kumar, In Su Lee
Summary: In this study, a nanoreactor platform was developed to synchronize reaction steps at unconnected sites, minimizing conflicting effects. The reaction process and product yields were controlled through convenient remote operations. The use of this platform enabled the successful implementation of a tandem reaction with excellent yield, opening possibilities for designing diverse catalytic schemes.
Article
Chemistry, Multidisciplinary
Anubhab Acharya, In Su Lee
Summary: Plasmonically coupled nanoreactors capable of harnessing light energy and efficiently transforming it to perform chemical reactions are in significant demand in the field of catalysis. The development of unique solution-phase synthesis techniques for engineering intricate nanoarchitectures by introducing multiple functionalities can dramatically improve the efficacy of these nanostructures. In this context, the precise modulation of the nanostructural features and the integration of other components with the plasmonic nanoparticles within an isolated nanoconfined reaction environment is the current state of the art for their synthesis.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Yu-Rim Hong, Sungho Choi, Soumen Dutta, Insu Jeong, Soojin Park, In Su Lee
Summary: By utilizing 1 nm-thin Ni3CoOx nanosheets, the efficient confinement effect of nanospace enables high-rate capability, outstanding cycle stability, and high Coulombic efficiency, which has not been achieved with other transition-metal oxides.
Article
Chemistry, Multidisciplinary
Kyeong-jun Jeong, Seungwon Jeong, Sangmin Lee, Chang Yun Son
Summary: Electrostatic interactions are crucial in charged materials systems, and the complexity of this task is further increased by the presence of interfaces. Predictive molecular simulations have proven their value in providing molecular understanding of physicochemical properties and functional mechanisms. This article presents an overview of recent advances in understanding charged interfacial systems using predictive molecular simulations.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Byeong Su Gu, Soumen Dutta, Yu-Rim Hong, Odongo Francis Ngome Okello, Hyeonae Im, Seungil Ahn, Si-Young Choi, Jeong Woo Han, Sunmin Ryu, In Su Lee
Summary: By modifying the surfaces of 2D-Pt nanodendrites, Pd and Ni were successfully deposited on the {110} facet and {111/100} edge, respectively, forming heterointerfaces. These differently located heterointerfaces exhibited different electronic effects, leading to different electrocatalytic activities in the hydrogen evolution reaction. The edge-located n-Ni showed faster water dissociation and outperformed the facet-located e-Pd in terms of catalytic activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Soumen Dutta, Akshay Gurumoorthi, Shinbi Lee, Sun Woo Jang, Nitee Kumari, Yu-Rim Hong, Wonyong Choi, Chang Yun Son, In Su Lee
Summary: By utilizing few-nm-thin two-dimensional nanocrystals of MOF-5, a crystal lattice-guided wet-chemical etching process has been developed to regulate attractive pore patterns on the MOF surface. The optimized etching process produces size-tunable fractal-pores that enhance the activity and stability of the supported catalyst in photoelectrochemical CO2-to-CO reduction. The long-range fractal opening in the 2D MOF support structure facilitates cross-interface charge transportation and exposure of immobilized Re-I-catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jeong Hun Choi, Nitee Kumari, Amit Kumar, Anubhab Acharya, Jungsoo Ahn, Jaerim Kim, Hyeonwoong Hwang, Taiha Joo, Jong Kyu Kim, In Su Lee
Summary: Silicon nanostructures can be used for various biomedical applications, but it is challenging to maintain their subhundred nm size during the silica-to-silicon conversion at high temperatures. The SC-SSR method utilizes a metal-silicide stratum space inside silica nanospheres to guide the synthesis of hollow and porous SiNSs through a magnesiothermic reduction reaction. The mechanism involves the participation of metal-silicide species to achieve solid-to-hollow transformation within a predefined radial boundary. The resulting hydrophilic SiNSs can be used as photoluminescence-based bioimaging probes in different biomedia, and rattle-like SiNSs encapsulated with Pd nanocrystals can catalyze intracellular synthesis of probe molecules through C-C cross coupling reaction.
Article
Nanoscience & Nanotechnology
Seong Hyeon Kim, Seungwon Jeong, Daegun Kim, Chang Yun Son, Kilwon Cho
Summary: Conjugated polymer (CP)/carbon nanotube (CNT) composites have been used for thermoelectrics for over a decade. The underlying origin of the performance improvement in CP/CNT composites remains unclear. By combining experimental approaches with molecular dynamics simulations, the contribution of CPs to the thermoelectric properties at inter-tube junctions between adjacent CNTs is revealed.
ADVANCED ELECTRONIC MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Soumen Dutta, Byeong Su Gu, In Su Lee
Summary: This paper reviews the synthesis and benefits of a new class of electrocatalytic materials, namely h-2D-PGM nanosheets, highlighting the importance of porous and two-dimensional structures in electrocatalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sun Woo Jang, Nitee Kumari, Eonu Nam, Yun Kyung Lee, Yunmi Cha, Kwangjin An, In Su Lee
Summary: Controlling the assembly of nanoparticles into well-defined structures allows the development of advanced materials with tailored properties. However, the controlled assembly of highly anisotropic 2D nanosheets is challenging. This research discovers the controlled self-assembly of 2D-silica nanosheets into hollow soccer ball-like shells, which exhibit high mechanical stability and excellent performance as catalyst support.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sampathkumar Jeevanandham, Ankur Maji, Anubhab Acharya, Nitee Kumari, Byeong Su Gu, Youngkwan Yoon, Hee Cheul Choi, Amit Kumar, In Su Lee
Summary: By sandwiching an ultrathin 2D-Cu layer inside a bilayer silica template, researchers discovered the important cooperative role of Lewis basic amino-silica microenvironment in the selective hydrogenation reaction catalyzed by copper. The newly developed nanospace-confined electrochemical atomic layer deposition technique allowed for the synthesis of an ultrathin Cu(0)-layer that transformed the originally non-reactive Cu film into an efficient catalyst. This study presents a new approach for controlling complex molecular interactions in heterogeneous catalysts.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yu-Rim Hong, Sungho Choi, Soumen Dutta, Insu Jeong, Soojin Park, In Su Lee
Summary: Nanoscale optimization of late transition-metal oxides is crucial for advancing next-generation Li-ion battery technologies by fixing the reversible lithiation/delithiation mechanism and understanding nanocrystal conversion chemistry in depth.