Article
Engineering, Biomedical
Yao Liu, Xiaonong Zhang, Chunsheng Xiao, Bin Liu
Summary: Peripheral nerve injury (PNI) is a complex disease that commonly affects young adults and has limited treatment options and poor clinical outcomes. Tissue-engineered hydrogels have shown promising results in promoting neural tissue regeneration and recovery of impaired neural function. This review discusses recent advances and various therapeutic strategies of hydrogels in peripheral nerve repair, as well as the prospects and challenges in their application for PNI treatment.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Baoqiang Guo, Xenia Sawkulycz, Nima Heidari, Ralph Rogers, Donghui Liu, Mark Slevin
Summary: The study of MFAT demonstrates that micro-fragmented adipose tissue from different samples can induce the formation of mesenchymal stem cells. The secretions of cytokines from MFAT samples have effects including anti-inflammatory, pro-regeneration, anti-scarring, pro-angiogenesis, and anti-bacterial properties. MFAT in different samples show varying effects on angiogenesis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Zain Siddiqui, Biplab Sarkar, Ka-Kyung Kim, Nurten Kadincesme, Reshma Paul, Arjun Kumar, Yoshifumi Kobayashi, Abhishek Roy, Marwa Choudhury, Jian Yang, Emi Shimizu, Vivek A. Kumar
Summary: The study demonstrates the potential of acellular self-assembling peptide hydrogels in promoting tissue revascularization and soft tissue regeneration after endodontic treatment. The hydrogels show promise in guiding the development of neovasculature and tissue deposition, providing a scaffold for soft tissue regeneration in vivo.
ACTA BIOMATERIALIA
(2021)
Review
Neurosciences
Wenqian Zhao, Hui Tu, Jianxiao Chen, Jing Wang, Haoting Liu, Fengshou Zhang, Jing Li
Summary: Repairing injuries to the nervous system has always been a prominent topic in clinical research. With the emergence of tissue engineering, hydrogel materials have been identified as a promising technology for repairing nervous system injuries. By controlling their composition and structure, hydrogels can be functionalized and almost fully matched with nerve tissue, making them suitable for repairing injuries to both the central and peripheral nervous systems.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Polymer Science
Fengshi Zhang, Meng Zhang, Songyang Liu, Ci Li, Zhentao Ding, Teng Wan, Peixun Zhang
Summary: This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration. Conductive hydrogels, with their unique physical and electrical properties, can mimic the biological and electrical characteristics of human nervous tissue.
Article
Engineering, Environmental
Zain Siddiqui, Biplab Sarkar, Ka Kyung Kim, Arjun Kumar, Reshma Paul, Aryan Mahajan, Jonathan M. Grasman, Jian Yang, Vivek A. Kumar
Summary: The study demonstrates the ability of self-assembling peptide hydrogels to promote angiogenic sprouting into polymeric scaffolds; the two-component scaffold structure helps to improve the biocompatibility and vascular integration of polymeric scaffolds; the functional difference of the peptide hydrogels can be predicted by the bioactive moieties inserted into the peptide monomers.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Engineering, Biomedical
Antonio J. Feliciano, Clemens van Blitterswijk, Lorenzo Moroni, Matthew B. Baker
Summary: In this paper, the design parameters and applications of supramolecular hydrogels in tissue engineering are discussed, highlighting their ability to facilitate tissue formation via dynamic interactions. By designing permissive supramolecular hydrogels, new dynamic implants for tissue engineering applications can be inspired.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Lovorka Grgurevic, Rudjer Novak, Grgur Salai, Stela Hrkac, Marko Mocibob, Ivana Kovacevic Vojtusek, Mario Laganovic
Summary: This study reveals the molecular characteristics of different stages of chronic kidney disease (CKD) through proteomic analysis, and identifies key events that may affect disease progression. The study suggests that CKD stage 2 is a turning point in the progression of the disease and a suitable time for developing therapeutic solutions.
Review
Biotechnology & Applied Microbiology
Zhiwen Yan, Cheng Chen, Gonzalo Rosso, Yun Qian, Cunyi Fan
Summary: This review examines the role of two-dimensional nanomaterials in promoting peripheral nerve regeneration by facilitating angiogenesis and supporting new vessel formation. The potential of two-dimensional nanomaterials as a solution for long-range peripheral nerve defects is highlighted, with strategies aimed at addressing energy deficiency post-injury being proposed to enhance therapeutic effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liping Zhou, Zehua Zeng, Songyang Liu, Tiantian Min, Wenmin Zhang, Xiaochun Bian, Hongwu Du, Peixun Zhang, Yongqiang Wen
Summary: This study proposes a multifunctional DNA hydrogel integrated system for the treatment of burn wounds. The system has various functions, such as pain and itch relief, promotion of cell proliferation and regeneration, and excellent antibacterial properties. The results of this study are of great importance for further understanding the mechanisms of burn treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Cell Biology
Matthew Burgess, Franklin Valdera, David Varon, Esko Kankuri, Kristo Nuutila
Summary: Burns are diverse and complex injuries that have local and systemic effects. Improvements in burn care have been made over the past decades. Severity of burns depends on size, depth, location, age, and underlying diseases.
Article
Dentistry, Oral Surgery & Medicine
X. Su, Y. Liu, O. ElKashty, J. Seuntjens, K. M. Yamada, S. D. Tran
Summary: This study investigated the potential of human bone marrow cell extract (BMCE) as a therapy for irradiation-induced salivary hypofunction. The results showed that BMCE, specifically the mononuclear cell extract (MCE) fraction, significantly increased salivary flow, preserved salivary gland cells, and promoted cell proliferation.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Parinaz Nezhad-Mokhtari, Siamak Javanbakht, Nahideh Asadi, Marjan Ghorbani, Morteza Milani, Younes Hanifehpour, Pourya Gholizadeh, Abolfazl Akbarzadeh
Summary: Honey has traditionally been used for wound treatment due to its antibacterial properties, and incorporation into hydrogels has been shown to overcome limitations in direct application. Studies have demonstrated that honey in hydrogels can reduce inflammation and improve healing processes such as angiogenesis and tissue formation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sachin Shukla, Won Kyung Cho, Elsayed Elbasiony, Rohan B. Singh, Sharad K. Mittal, Sunil K. Chauhan
Summary: Regulation of innate inflammation is crucial for tissue homeostasis and barrier function, especially in the skin and cornea. IL36 gamma is the primary agonist expressed by corneal epithelium and is upregulated after corneal injury. Blocking IL36 gamma promotes rapid re-epithelialization and suppresses tissue inflammation.
Article
Nanoscience & Nanotechnology
Zehua Gao, Yuanman Yu, Kai Dai, Tingting Zhang, Luli Ji, Xuanlin Wang, Jing Wang, Changsheng Liu
Summary: This study investigates the impact of inflammation on the heterogeneity of neutrophils and incorporates it into a scaffold material for ischemia treatment. The study demonstrates that anti-inflammatory neutrophils can promote migration of endothelial cells and formation of capillary networks. Vascular anastomosis can be achieved by modulating the neutrophils. The scaffold material can regulate inflammation, promote angiogenesis, and support the survival of exogenous cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)