Chronodisruption by chronic jetlag impacts metabolic and gastrointestinal homeostasis in male mice

Circadian clocks in the digestive system

(2021) Anneleen Segers et al.   Nature Reviews Gastroenterology & Hepatology

Night-time feeding of Bmal1-/- mice restores SCFA rhythms and their effect on ghrelin

(2020) Anneleen Segers et al.   JOURNAL OF ENDOCRINOLOGY

Circadian GLP-1 Secretion in Mice is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis

(2020) Sarah E. Martchenko et al.   DIABETES

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

(2019) Jonathan Cedernaes et al.   Cell Metabolism

Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity

(2019) Joseph Amara et al.   DIGESTIVE DISEASES AND SCIENCES

The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1

(2019) Andrew D. Biancolin et al.   Molecular Metabolism

Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome

(2018) Laura Kervezee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue

(2018) Yu Tahara et al.   Scientific Reports

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition

(2018) Jessica A. Deaver et al.   Frontiers in Microbiology

A rotating light cycle promotes weight gain and hepatic lipid storage in mice.

(2018) Stewart Christie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Time zones of pancreatic islet metabolism

(2018) Volodymyr Petrenko et al.   DIABETES OBESITY & METABOLISM

Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans

(2018) Jingyi Qian et al.   INTERNATIONAL JOURNAL OF OBESITY

The circadian clock regulates the diurnal levels of microbial short-chain fatty acids and their rhythmic effects on colon contractility in mice

(2018) Anneleen Segers et al.   Acta Physiologica

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

(2018) Wenyan He et al.   IMMUNITY

Ghrelin Restores the Disruption of the Circadian Clock in Steatotic Liver

(2018) Qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

(2018) Shuai Wang et al.   Nature Communications

From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation

(2017) Ken Howick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid resetting of human peripheral clocks by phototherapy during simulated night shift work

(2017) Marc Cuesta et al.   Scientific Reports

Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers

(2016) Manuel Gil-Lozano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk

(2016) Kalaimathi Govindarajan et al.   PLoS One

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

Circadian Dysfunction Induces Leptin Resistance in Mice

(2015) Nicole M. Kettner et al.   Cell Metabolism

Chronobesity: role of the circadian system in the obesity epidemic

(2015) J. Laermans et al.   Obesity Reviews

Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome

(2015) Atish Mukherji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

(2015) Xue Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the clock gene Bmal1 and the gastric ghrelin-secreting cell in the circadian regulation of the ghrelin-GOAT system

(2015) J. Laermans et al.   Scientific Reports

Disruption of Daily Rhythms by High-Fat Diet Is Reversible

(2015) Katrina L. Branecky et al.   PLoS One

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

(2014) Christoph A. Thaiss et al.   CELL

Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome

(2014) Amir Zarrinpar et al.   Cell Metabolism

Circadian Secretion of the Intestinal Hormone GLP-1 by the Rodent L Cell

(2014) Manuel Gil-Lozano et al.   DIABETES

Glucagon-CREB/CRTC2 Signaling Cascade Regulates Hepatic BMAL1 Protein

(2014) Xiujie Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin Receptor Regulates Appetite and Satiety during Aging in Mice by Regulating Meal Frequency and Portion Size but Not Total Food Intake

(2014) Ligen Lin et al.   JOURNAL OF NUTRITION

Expressions of Tight Junction Proteins Occludin and Claudin-1 Are under the Circadian Control in the Mouse Large Intestine: Implications in Intestinal Permeability and Susceptibility to Colitis

(2014) Kyoko Oh-oka et al.   PLoS One

Shifting the Circadian Rhythm of Feeding in Mice Induces Gastrointestinal, Metabolic and Immune Alterations Which Are Influenced by Ghrelin and the Core Clock Gene Bmal1

(2014) Jorien Laermans et al.   PLoS One

Ablation of AgRP neurons impairs adaption to restricted feeding

(2014) Keith Tan et al.   Molecular Metabolism

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

High-fat diet acutely affects circadian organisation and eating behavior

(2013) Julie S. Pendergast et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight

(2013) Laura K. Fonken et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

(2013) Keith C. Summa et al.   PLoS One

TH17 Cell Differentiation Is Regulated by the Circadian Clock

(2013) X. Yu et al.   SCIENCE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Effect of a phase advance and phase delay of the 24-h cycle on energy metabolism, appetite, and related hormones

(2012) Hanne KJ Gonnissen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Clock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms

(2012) Gianluigi Mazzoccoli et al.   CHRONOBIOLOGY INTERNATIONAL

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

(2012) Christoph Scheiermann et al.   IMMUNITY

Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork

(2012) Johanna L. Barclay et al.   PLoS One

Hormonal appetite control is altered by shift work: a preliminary study

(2011) Cibele Aparecida Crispim et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diurnal Variations of Mouse Plasma and Hepatic Bile Acid Concentrations as well as Expression of Biosynthetic Enzymes and Transporters

(2011) Yu-Kun Jennifer Zhang et al.   PLoS One

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying

(2011) Sara Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gastrointestinal disorders among shift workers

(2011) Anders Knutsson et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Effects of glucagon-like peptide 1 and oxyntomodulin on neuronal activity of ghrelin-sensitive neurons in the hypothalamic arcuate nucleus

(2010) Thomas Riediger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Impact of Clock Gene Bmal1 Deficiency on Nutritionally Induced Obesity in Mice

(2010) Bianca Hemmeryckx et al.   Obesity

Circadian Dysregulation Disrupts Bile Acid Homeostasis

(2009) Ke Ma et al.   PLoS One

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stomach ghrelin-secreting cells as food-entrainable circadian clocks

(2009) J. LeSauter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian clock in macrophages controls inflammatory immune responses

(2009) Maren Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA