Article
Multidisciplinary Sciences
Ki Won Jin, Jae Hui Kim, Jun Young Park, Sang Jun Park, Kyu Hyung Park, Joo Yong Lee, Se Joon Woo
Summary: This study evaluated the long-term outcomes of ranibizumab (RBZ) vs. aflibercept (AFL) in treatment-naive eyes with typical neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). The results showed no significant difference in visual outcomes and number of injections between the two treatments over the course of 4 years.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Young-Joon Jeon, Jae-Hui Kim, Jong-Woo Kim, Chul-Gu Kim
Summary: This study evaluated the short-term outcomes of switching to ranibizumab in aflibercept-resistant polypoidal choroidal vasculopathy. The results showed that switching to ranibizumab was not effective for most patients, with only a small proportion showing improvement in retinal thickness or complete resolution of fluid after the switch.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Kenji Yamashiro, Yasuo Yanagi, Hideki Koizumi, Hidetaka Matsumoto, Chui Ming Gemmy Cheung, Fumi Gomi, Tomohiro Iida, Akitaka Tsujikawa
Summary: Previous studies have shown inconsistent classification and understanding of pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). This study summarizes previous research and proposes a refined conceptual framework for future studies on PNV, PCV, and neovascular age-related macular degeneration (nAMD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Arisa Ito, Maiko Maruyama-Inoue, Yoko Kitajima, Shoko Ikeda, Tatsuya Inoue, Kazuaki Kadonosono
Summary: This study retrospectively evaluated the 1-year visual and anatomic outcomes of Japanese patients with PCV who received IVBr injections. The results showed that IVBr injections were effective in improving both functional and anatomic outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Hsin-Yu Weng, Tzu-Lun Huang, Pei-Yao Chang, Wei-Ting Ho, Yung-Ray Hsu, Fang-Ting Chen, Yun-Ju Chen, Jia-Kang Wang
Summary: The study compared the two-year visual and anatomical outcomes of PCV patients treated with combined PDT therapy using IVA and IVR. Results showed significant improvement in BCVA at 6-month follow-up in the IVA/PDT group, while only at 6 months and 12 months in the IVR/PDT group. The two groups had comparable BCVA/CRT changes and complete polyp regression rates, but the IVA/PDT group required less retreatment and achieved more dry macula outcomes.
APPLIED SCIENCES-BASEL
(2021)
Article
Ophthalmology
Maria Vadala, Massimo Castellucci, Giulia Guarrasi, Giovanni Cillino, Vincenza Maria Elena Bonfiglio, Alessandra Casuccio, Salvatore Cillino
Summary: The study demonstrates that combined therapy with intravitreal Aflibercept and photodynamic therapy can significantly improve visual acuity and reduce intraretinal and subretinal fluid in PPCV, achieving therapeutic effects.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yoshiko Fukuda, Yoichi Sakurada, Mio Matsubara, Yuka Hasebe, Atsushi Sugiyama, Wataru Kikushima, Kenji Kashiwagi
Summary: This study compared the short-term outcomes of aflibercept and brolucizumab in treating polypoidal choroidal vasculopathy, showing similar improvements in visual acuity, morphology, and complete regression of polypoidal lesions. However, brolucizumab was more effective in reducing subfoveal choroidal thickness.
Article
Ophthalmology
Jiyang Tang, Xinyao Han, Ran Tang, Mengyang Li, Zongyi Wang, Mingwei Zhao, Jinfeng Qu
Summary: Pachychoroid pigment epitheliopathy (PPE) may transform into central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV) during follow-up. Long-term regular follow-up is recommended for patients with PPE.
Article
Medicine, General & Internal
Yin Xue, Qinhua Cai
Summary: This study compared the short-term efficacy of aflibercept and conbercept in the treatment of patients with polypoidal choroidal vasculopathy (PCV). The results suggest that aflibercept may provide a superior short-term response compared to conbercept.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Kelvin Yi Chong Teo, Janice Marie Jordan-Yu, Anna C. S. Tan, Ian Y. S. Yeo, Ranjana Mathur, Choi Mun Chan, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
Summary: The personalised regimen was non-inferior to the fixed regimen in terms of BCVA improvement, and showed numerically higher closure of PL. Further results also demonstrated that the personalised group had a greater reduction in CSFT compared to the fixed group.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Siyin Liu, Ramandeep Chhabra
Summary: This study compared the effectiveness of PDT combined with IVR or IVA for treating PCV. The results showed that both IVR and IVA combined with PDT were effective treatments for European PCV patients. However, when IVR was ineffective, performing PDT promptly may be more beneficial than switching to IVA.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Anna C. S. Tan, Janice Marie Jordan-Yu, Chinmayi Himanshuroy Vyas, Alfred Tau Liang Gan, Kelvin Yi Chong Teo, Choi Mun Chan, Ranjana Mathur, Tien Yin Wong, Usha Chakravarthy, Gemmy Chui Ming
Summary: The purpose of this study was to evaluate whether optical coherence tomography (OCT) can determine the perfusion of polypoidal lesions (PL) in eyes with polypoidal choroidal vasculopathy after 12 months of aflibercept monotherapy. The results showed that specific OCT features can accurately detect the closure of polypoidal lesions, which is an important anatomical treatment outcome typically defined by indocyanine green angiography.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Seonghee Choi, Hae Min Kang, Hyoung Jun Koh
Summary: Identifying a super stable subset of polypoidal choroidal vasculopathy (PCV) patients who have a long period of remission following anti-vascular endothelial growth factor (VEGF) therapy can help prevent overtreatment and lessen treatment burden. Patients in the super stable group were younger, had a higher ratio of females, greater choroidal thickness, more single polyps, smaller largest polyp diameter, and showed superior response in OCT features at 3 months after treatment. Factors such as age, polyp configuration, PED diameter at 3 months, and change in PED height at 3 months were associated with super stable remission.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Janice Marie Jordan-Yu, Kelvin Yi Chong Teo, Usha Chakravarthy, Alfred Gan, Anna Cheng Sim Tan, Kai Xiong Cheong, Tien Yin Wong, Chui Ming Gemmy Cheung
Summary: This study found that in PCV lesions, there is a significant linear increase in total lesion area and polypoidal lesion area with increasing subfoveal choroidal thickness.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Kentaro Kawai, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Ayako Takahashi, Akihito Uji, Yuki Muraoka, Masahiro Miyake, Kenji Yamashiro, Akitaka Tsujikawa
Summary: This study found that a thin subfoveal choroid at baseline and multiple anti-VEGF injections in a PRN regimen increase the risk of developing macular atrophy (MA) involving the fovea after photodynamic therapy (PDT) and PRN treatment.
Article
Ophthalmology
Ryo Asaoka, Manabu Miyata, Akio Oishi, Yuri Fujino, Hiroshi Murata, Keiko Azuma, Ryo Obata, Tatsuya Inoue
Summary: This study investigated the association between visual acuity and visual field in patients with retinitis pigmentosa. The results showed that the association between visual sensitivity and visual acuity was strongest at the fovea and decreased towards the peripheral region. Additionally, as visual acuity decreased, the reproducibility of the visual field tests increased.
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Ophthalmology
Yuki Hama, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Yuki Muraoka, Masahiro Miyake, Ayako Takahashi, Tomotaka Wakazono, Akihito Uji, Kenji Yamashiro, Akitaka Tsujikawa
Summary: The study aimed to investigate the 7-year best-corrected visual acuity (BCVA) course of neovascular age-related macular degeneration (nAMD) patients after a 1-year fixed regimen of intravitreal aflibercept injection (IVA). The results showed that the BCVA in nAMD patients could be maintained for 7 years after the 1-year fixed regimen of IVA, emphasizing the importance of early diagnosis and treatment for long-term good visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Masato Akiyama, Masahiro Miyake, Yukihide Momozawa, Satoshi Arakawa, Maiko Maruyama-Inoue, Mikiko Endo, Yusuke Iwasaki, Kazuyoshi Ishigaki, Nana Matoba, Yukinori Okada, Miho Yasuda, Yuji Oshima, Shigeo Yoshida, Shin-ya Nakao, Kazuya Morino, Yuki Mori, Ai Kido, Aki Kato, Tsutomu Yasukawa, Ryo Obata, Yoshimi Nagai, Kanji Takahashi, Kimihiko Fujisawa, Akiko Miki, Makoto Nakamura, Shigeru Honda, Hiroaki Ushida, Tetsuhiro Yasuma, Koji M. Nishiguchi, Ryusaburo Mori, Koji Tanaka, Yu Wakatsuki, Kenji Yamashiro, Kazuaki Kadonosono, Chikashi Terao, Tatsuro Ishibashi, Akitaka Tsujikawa, Koh-Hei Sonoda, Michiaki Kubo, Yoichiro Kamatani
Summary: The genetic architecture of age-related macular degeneration (AMD) in a Japanese population was investigated through a genome-wide association study (GWAS). A meta-analysis of two GWASs identified six loci significantly associated with AMD, including four known loci and two novel loci. These associations were confirmed in a replication study and showed significant associations with central serous chorioretinopathy (CSC) as well. Genetic correlation analysis indicated shared polygenic architecture between AMD and smoking cessation.
Article
Ophthalmology
Masahiro Miyake, Shin-ya Nakao, Kazuya Morino, Shota Yasukura, Yuki Mori, Kenji Ishihara, Yuki Muraoka, Manabu Miyata, Hiroshi Tamura, Taiji Sakamoto, Akitaka Tsujikawa
Summary: This study aimed to evaluate the association between the duration of macular detachment (DMD) and visual prognosis in patients with macula-off rhegmatogenous retinal detachment (RD). The results showed that surgical treatment within 3 days from the onset of macular detachment significantly improved visual prognosis.
OPHTHALMOLOGY RETINA
(2023)
Article
Medicine, General & Internal
Rosie Clark, Samantha Sze-Yee Lee, Ran Du, Yining Wang, Sander C. M. Kneepkens, Jason Charng, Yu Huang, Michael L. Hunter, Chen Jiang, J. Willem L. Tideman, Ronald B. Melles, Caroline C. W. Klaver, David A. Mackey, Cathy Williams, Helene Choquet, Kyoko Ohno-Matsui, Jeremy A. Guggenheim
Summary: This study aimed to predict the risk of high myopia (HM) through an improved polygenic score (PGS) and test if the PGS is predictive of myopic macular degeneration (MMD) after considering refractive error. The study found that PGS can predict the risk of HM in Europeans, but its predictive ability is weaker in other populations.
Article
Multidisciplinary Sciences
Shotaro Asano, Ryo Asaoka, Akio Oishi, Yuri Fujino, Hiroshi Murata, Keiko Azuma, Manabu Miyata, Ryo Obata, Tatsuya Inoue
Summary: The purpose of this study was to investigate the clinical validity of the Guided Progression Analysis definition (GPAD) and cluster-based definition (CBD) with the Humphrey Field Analyzer (HFA) 10-2 test in retinitis pigmentosa (RP). The results showed that the GPAD and Hybrid Definition exhibited similar ability for the detection of progression, with a specificity of 95.4%.
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Takahiro Kogo, Yuki Muraoka, Masaharu Ishikura, Naomi Nishigori, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: The purpose of this study was to investigate choroidal angiographic features associated with the resolution or persistency of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC). The study found that vertically asymmetric dilation of choroidal vessels in the posterior pole may be a good predictor of future SRF status.