Article
Veterinary Sciences
Katja-Nicole Adamik, Michael H. Stoffel, Simone Tangermann, Bettina de Breuyn Dietler, Nadine Stokar-Regenscheit
Summary: This study investigated the severity of intracellular storage of HES in renal tissue samples from critically ill dogs receiving 6% HES 130/0.4. The results showed that a high percentage of dogs had renal tubular HES storage and one-third of dogs showed HES-induced osmotic nephrosis. Short-term HES administration caused vacuolization and accumulation, regardless of the dose or duration of administration.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Barbara Bruno, Roberta Troia, Francesco Dondi, Cristiana Maurella, Paola Gianella, Ilaria Lippi, Alberto Tarducci, Antonio Borrelli
Summary: This study evaluated the effects of constant rate infusion of HES 130/0.4 on renal biomarkers in dogs. The results indicated that in hypoalbuminemic dogs, the dose and rate of HES infusion did not lead to significant changes in the investigated biomarkers of kidney injury. Further prospective studies are needed to assess the renal safety profile of low-molecular-weight HES administration in more severely affected dogs.
Article
Polymer Science
Tsuneo Tatara
Summary: The study investigated the effects of albumin and hydroxyethyl starch (HES) on solute permeation through sodium hyaluronic acid (NaHA) solutions, showing that albumin had longer relative permeation time compared to HES.
Article
Medicine, Research & Experimental
Clementina Duran Palma, Musawenkosi Mamba, Johan Geldenhuys, Oluwafolajimi Fadahun, Rolf Rossaint, Kai Zacharowski, Martin Brand, Oscar Diaz-Cambronero, Javier Belda, Martin Westphal, Ute Brauer, Dirk Dormann, Tamara Dehnhardt, Martin Hernandez-Gonzalez, Sonja Schmier, Dianne de Korte, Frank Plani, Wolfgang Buhre
Summary: This study aims to compare the use of 6% HES 130 solution with electrolyte solution in volume replacement therapy for traumatic injuries, and evaluate its safety and efficacy.
Review
Anesthesiology
Yi Xu, Siying Wang, Leilei He, Hong Yu, Hai Yu
Summary: This meta-analysis investigated the clinical effects of perioperative use of HES 130/0.4 in surgical patients. The results showed no significant differences in postoperative mortality or kidney dysfunction between HES 130/0.4 and other fluids, but further large-scale studies are needed to confirm these findings.
PERIOPERATIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Erika Yaguchi, Tomoaki Ujita, Shinsuke Hamaguchi
Summary: This study aimed to evaluate the utility of 6% hydroxyethyl starch (HES) 130/0.4 in oral cancer surgeries with durations over 6 hours. The results showed that administration of 6% HES130/0.4 at a dose lower than 25 mL/kg was effective for circulation maintenance but did not increase intraoperative blood loss or transfusion volume. This treatment did not cause any dilutional metabolic acidosis or renal dysfunction.
Article
Neurosciences
Ayaka Fujita, Masashi Matsuzaka, Norifumi Metoki, Joji Hagii, Hiroshi Shiroto, Manabu Iwata, Rina Tanaka, Eiichi Tsuda
Summary: Hydration therapy with HES 130/0.4 significantly decreased the total costs and hospitalisation duration of patients with SI in the posterior LSA territory.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Multidisciplinary Sciences
Ryu Azumaguchi, Yasuyuki Tokinaga, Satoshi Kazuma, Motonobu Kimizuka, Kosuke Hamada, Tomoe Sato, Michiaki Yamakage
Summary: This study compared the effects of different concentrations of HES and physiological saline on blood coagulation using a rat model. The results suggest that HES may protect the endothelium and glycocalyx by covering them, but may also cause coagulopathy by inhibiting the secretion of von Willebrand factor.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kei Nagaya, Akiko Yoshida, Yosuke Ito, Suguru Watanabe, Tadanori Minagawa, Yoshifumi Saijo
Summary: This study aimed to investigate the impact of HES 130/0.4 on postoperative renal function in patients undergoing cardiac surgery using cardiopulmonary bypass. The results showed that there was no significant difference in the occurrences or stages of acute kidney injury within 30 days following surgery between patients administered with HES 130/0.4 or Ringer's bicarbonate.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Kei Nagaya, Akiko Yoshida, Yosuke Ito, Suguru Watanabe, Tadanori Minagawa, Yoshifumi Saijo
Summary: There was no significant difference in the occurrences or stages of AKI during the 30 days following cardiac surgery with cardiopulmonary bypass between patients administered with HES 130/0.4 or Ringer's bicarbonate.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Benedict Morath, Andreas D. Meid, Johannes Rickmann, Jasmin Soethoff, Markus Verch, Matthias Karck, Marcin Zaradzki
Summary: This study found that postoperative administration of HES may reduce the occurrence of acute kidney injury in patients after cardiac surgery, and there was no association between HES and 90-day mortality. The study suggests that HES may be safely administered to cardiac surgery patients for better renal outcomes, especially if administered early and dosed appropriately.
Article
Pharmacology & Pharmacy
Wanfang Zhu, Ruyi Wang, Fulei Liu, Zhongtao Zhang, Xiaoxian Huang, Jiaxin Zhu, Feng Feng, Wenyuan Liu, Wei Qu
Summary: Gambogic acid (GA), although approved for phase III clinical trial, has limitations due to its short half-life, low water solubility, poor stability, and inflammatory response. A self-assembled nanoparticle called GA-HES/NPs was designed to address these issues and enhance the therapeutic effect of GA by prolonging circulation time and improving tumor penetration ability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chen Xiao, Jiayuan Li, Xing Wang, Shiyou Li, Chen Xu, Zhijie Zhang, Ao Hua, Ze-yang Ding, Bi-xiang Zhang, Xiangliang Yang, Zifu Li
Summary: Cancer stem cells (CSCs) are responsible for tumor progression, treatment resistance, metastasis, and recurrence, but few drugs have successfully eliminated CSCs by increasing oxidative stress. In this study, we introduced hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@HES NPs) that effectively suppressed CSCs in vitro and in various in vivo tumor models. The CuET@HES NPs also showed great efficacy in inhibiting CSCs in fresh tumor tissues from hepatocellular carcinoma patients. This research has significant implications for the development of CSC-targeting nanomedicines.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Chen Xu, Shiyou Li, Jitang Chen, Huimin Wang, Zheng Li, Qingyuan Deng, Jiayuan Li, Xing Wang, Yuxuan Xiong, Zhijie Zhang, Xiangliang Yang, Zifu Li
Summary: This study demonstrates that the combination of doxorubicin (Dox) and erastin loaded in hydroxyethyl starch-polycaprolactone nanoparticles (DEPH NPs) can eliminate cancer stem cells (CSCs) and cancer cells by regulating redox status. By depleting intracellular glutathione (GSH) and boosting Dox-induced reactive oxygen species (ROS), DEPH NPs effectively suppress CSCs self-renewal, promote differentiation, and induce apoptosis in differentiated cancer cells. DEPH NPs show promising potential as a treatment for CSCs-rich solid tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Anesthesiology
Daniel Chappell, Philippe van der Linden, Javier Ripolles-Melchor, Michael F. M. James
Summary: This meta-analysis evaluated the safety and efficacy of 6% HES during surgery and in trauma, showing that HES can lower postoperative serum creatinine, improve hemodynamic stability, reduce the need for vasopressors, and decrease hospital stay compared to crystalloids alone. The results suggest that combining intravenous fluid therapy with crystalloids and HES as colloid has clinically beneficial effects.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Elena Crescioli, Jens O. Riis, Ulla M. Weinreich, Jens Ulrik S. Jensen, Lone M. Poulsen, Anne C. Brochner, Theis Lange, Anders Perner, Thomas L. Klitgaard, Olav L. Schjorring, Bodil S. Rasmussen
Summary: The study aims to compare the long-term effects of different oxygenation targets (lower and higher) on cognitive and pulmonary function in ICU patients with acute hypoxaemic respiratory failure. It will evaluate these effects on Danish patients and explore the potential impacts of different targets.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Article
Critical Care Medicine
Christine Marie Baeko Halling, Morten Hylander Moller, Soren Marker, Mette Krag, Jakob Kjellberg, Anders Perner, Dorte Gyrd-Hansen
Summary: Pantoprazole reduces clinically important gastrointestinal bleeding in ICU patients at risk, but does not significantly impact 1-year mortality, healthcare resource use, or employment status.
INTENSIVE CARE MEDICINE
(2022)
Article
Anesthesiology
Carl Thomas Anthon, Frederic Pene, Anders Perner, Elie Azoulay, Kathryn Puxty, Andry Van de Louw, Andreas Barratt-Due, Sanjay Chawla, Pedro Castro, Pedro Povoa, Luis Coelho, Victoria Metaxa, Laveena Munshi, Matthias Kochanek, Tobias Liebregts, Thomas Kander, Johanna Hastbacka, Morten Hylander Moller, Lene Russell
Summary: The international cohort study aims to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in adult ICU patients. The study will collect data from at least 1000 acutely admitted adult ICU patients and focus on the occurrence and mortality rate of thrombocytopenia, as well as indications for platelet transfusion.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Article
Anesthesiology
Nicolai Haase, Ronni Plovsing, Steffen Christensen, Lone M. Poulsen, Anne C. Brochner, Bodil S. Rasmussen, Marie Helleberg, Jens U. S. Jensen, Lars P. K. Andersen, Hanna Siegel, Michael Ibsen, Vibeke L. Jorgensen, Robert Winding, Susanne Iversen, Henrik P. Pedersen, Jacob Madsen, Christoffer Solling, Ricardo S. Garcia, Jens Michelsen, Thomas Mohr, George Michagin, Ulrick S. Espelund, Helle Bundgaard, Lynge Kirkegaard, Margit Smitt, David L. Buck, Niels-Erik Ribergaard, Helle S. Pedersen, Birgitte V. Christensen, Lone P. Nielsen, Esben Clapp, Trine B. Jonassen, Sarah Weihe, Kirstine la Cour, Frederik M. Nielsen, Emilie K. Madsen, Trine N. Haberlandt, Nick Meier, Anders Perner
Summary: After the first wave of COVID-19 in Denmark, a lower proportion of hospitalized patients with COVID-19 were admitted to ICU. Among ICU patients, use of organ support was lower and length of stay was reduced, but mortality rates remained relatively high.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Article
Anesthesiology
Sarah Weihe, Camilla B. Mortensen, Nicolai Haase, Lars P. K. Andersen, Thomas Mohr, Hanna Siegel, Michael Ibsen, Vibeke R. L. Jorgensen, David L. Buck, Helle B. S. Pedersen, Henrik P. Pedersen, Susanne Iversen, Niels Ribergaard, Bodil S. Rasmussen, Robert Winding, Ulrick S. Espelund, Helle Bundgaard, Christoffer G. Solling, Steffen Christensen, Ricardo S. Garcia, Anne C. Brochner, Jens Michelsen, George Michagin, Lynge Kirkegaard, Anders Perner, Ole Mathiesen, Lone M. Poulsen
Summary: ICU admission due to COVID-19 may result in long-term cognitive and physical impairment, including cognitive and functional impairment and fatigue.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Review
Critical Care Medicine
Anders Granholm, Carl T. Anthon, Maj-Brit N. Kjaer, Mathias Maagaard, Benjamin S. Kaas-Hansen, Praleene Sivapalan, Olav L. Schjorring, Lars W. Andersen, Ole Mathiesen, Thomas Strom, Aksel K. G. Jensen, Anders Perner, Morten H. Moller
Summary: This scoping review aims to examine how recent clinical trials handle challenges such as outcome selection, deceased patients, and missing data in analyses.
CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
T. S. Meyhoff, P. B. Hjortrup, J. Wetterslev, P. Sivapalan, J. H. Laake, M. Cronhjort, S. M. Jakob, M. Cecconi, M. Nalos, M. Ostermann, M. Malbrain, V Pettila, M. H. Moller, M-B N. Kjaer, T. Lange, C. Overgaard-Steensen, B. A. Brand, M. Winther-Olesen, J. O. White, L. Quist, B. Westergaard, A. B. Jonsson, C. J. S. Hjortso, N. Meier, T. S. Jensen, J. Engstrom, L. Nebrich, N. C. Andersen-Ranberg, J. Jensen, N. A. Joseph, L. M. Poulsen, L. S. Herlov, C. G. Solling, S. K. Pedersen, K. K. Knudsen, T. S. Straarup, M. L. Vang, H. Bundgaard, B. S. Rasmussen, S. R. Aagaard, T. Hildebrandt, L. Russell, M. H. Bestle, M. Schonemann-Lund, A. C. Brochner, C. F. Elvander, S. K. L. Hoffmann, M. L. Rasmussen, Y. K. Martin, F. F. Friberg, H. Seter, T. N. Aslam, S. Adnoy, P. Seidel, K. Strand, B. Johnstad, E. Joelsson-Alm, J. Christensen, C. Ahlstedt, C. A. Pfortmueller, M. Siegemund, M. Greco, J. Radej, M. Kriz, D. W. Gould, K. M. Rowan, P. R. Mouncey, A. Perner
Summary: The study found that restricting intravenous fluid therapy in adult patients with septic shock in the ICU did not lead to fewer deaths at 90 days compared to standard intravenous fluid therapy. Other survival indicators during ICU stay and at 90 days were similar in both groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Critical Care Medicine
Sine Wichmann, Marija Barbateskovic, Ning Liang, Theis Skovsgaard Itenov, Rasmus Ehrenfried Berthelsen, Jane Lindschou, Anders Perner, Christian Gluud, Morten Heiberg Bestle
Summary: This study systematically reviewed the benefits and harms of loop diuretics, the predominant treatment for fluid overload in intensive care unit (ICU) patients. The results showed that there was no significant difference in mortality rate, but fewer serious adverse events were observed in the loop diuretic group. However, the evidence on the effects of loop diuretics on these outcomes is very uncertain.
ANNALS OF INTENSIVE CARE
(2022)
Review
Anesthesiology
Benjamin Skov Kaas-Hansen, Anders Granholm, Carl Thomas Anthon, Maj-Brit Norregaard Kjaer, Praleene Sivapalan, Mathias Maagaard, Olav Lilleholt Schjorring, Steen Kare Fagerberg, Karen Louise Ellekjaer, Jesper Molgaard, Claus Thorn Ekstrom, Morten Hylander Moller, Anders Perner
Summary: This scoping review aims to assess the use of causal inference methods and secondary data for planned predictive enrichment in randomised critical care trials. The findings will help guide methodological improvements in planning such trials in the future.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Nina C. Andersen-Ranberg, Lone M. Poulsen, Anders Perner, Jorn Wetterslev, Stine Estrup, Johanna Haestbacka, Matt Morgan, Giuseppe Citerio, Jesus Caballero, Theis Lange, Maj-Brit N. Kjaer, Bjorn H. Ebdrup, Janus Engstrom, Markus H. Olsen, Marie Oxenboll Collet, Camilla B. Mortensen, Sven-Olaf Weber, A. Sofie Andreasen, Morten H. Bestle, Buelent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Hans C. Toft Boesen, Jacob V. Jensen, Lars Nebrich, Kirstine La Cour, Jens Laigaard, Cecilie Haurum, Marie W. Olesen, Christian Overgaard-Steensen, Bo Westergaard, Bjorn A. Brand, Gitte Kingo Vesterlund, Pernille Thornberg Kyhnauv, Vibe S. Mikkelsen, Simon Hyttel-Sorensen, Inge de Haas, Soren R. Aagaard, Line O. Nielsen, Anne S. Eriksen, Bodil S. Rasmussen, Helene Brix, Thomas Hildebrandt, Martin Schonemann-Lund, Hans Fjeldsoe-Nielsen, Anna-Maria Kuivalainen, Ole Mathiesen, AID ICU Trial Grp
Summary: This study examined the use of haloperidol in treating delirium in the ICU and found that it did not result in a significantly higher number of days alive and out of the hospital at 90 days compared to placebo. Additionally, the mortality rate at 90 days was slightly lower in the haloperidol group compared to the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Hematology
Carl Thomas Anthon, Anders Granholm, Praleene Sivapalan, Nuria Zellweger, Frederic Pene, Kathryn Puxty, Anders Perner, Morten Hylander Moller, Lene Russell
Review
Anesthesiology
Mathias Maagaard, Marija Barbateskovic, Nina C. Andersen-Ranberg, Jonas R. Kronborg, Ya-Xin Chen, Huan-Huan Xi, Anders Perner, Jorn Wetterslev
Summary: This systematic review of randomized clinical trials found that dexmedetomidine may reduce the occurrence of serious adverse events and delirium in intensive care or post-operative care units. However, there was no conclusive evidence for its effects on all-cause mortality. The certainty of evidence ranged from very low for delirium to low for the remaining outcomes.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Review
Anesthesiology
Marie Warrer Munch, Anders Granholm, Andreas Bender Jonsson, Fredrik Sjovall, Marie Helleberg, Frederik Botius Hertz, Jakob Steen Andersen, Morten Steensen, Michael Patrick Achiam, Anders Perner, Morten Hylander Moller
Summary: This study aimed to compare the desirable and undesirable effects of piperacillin/tazobactam versus carbapenems in patients with severe bacterial infections. The results suggest that piperacillin/tazobactam may be associated with less favorable outcomes in patients with severe bacterial infections compared to carbapenems.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Gitte K. Vesterlund, Hans-Christian Thorsen-Meyer, Morten H. Moller, Soren Brunak, Thomas Strom, Anders Perner, Benjamin S. Kaas-Hansen
Summary: This study aimed to describe abnormal serum levels of magnesium, phosphate, and zinc in Danish ICU patients and assess their associations with outcomes. The results showed that most ICU patients had low serum levels of magnesium, phosphate, or zinc, and some received supplementation. However, the associations between serum levels and clinical outcomes were inconclusive due to insufficient data.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Letter
Medicine, General & Internal
Tine S. Meyhoff, Praleene Sivapalan, Anders Perner
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
