Hepta-Histidine Inhibits Tau Aggregation

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

(2020) Hikari Tanaka et al.   Nature Communications

Impact of the Hereditary P301L Mutation on the Correlated Conformational Dynamics of Human Tau Protein Revealed by the Paramagnetic Relaxation Enhancement NMR Experiments

(2020) Ryosuke Kawasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease

(2019) Makoto Hashimoto et al.   Journal of Parkinsons Disease

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all- d -enantiomeric peptides developed for the treatment of Alzheimer's disease

(2018) Elena Schartmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation

(2018) Teikichi Ikura et al.   FEBS LETTERS

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries

(2016) Tomomi Imamura et al.   Scientific Reports

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating

(2013) T. Ikura et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Polyglutamine neurodegeneration: expanded glutamines enhance native functions

(2012) Harry T Orr   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mutant huntingtin impairs Ku70-mediated DNA repair

(2010) Yasushi Enokido et al.   JOURNAL OF CELL BIOLOGY

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

(2009) Tetsuaki Arai et al.   ACTA NEUROPATHOLOGICA

Transactive Response DNA-Binding Protein 43 Burden in Familial Alzheimer Disease and Down Syndrome

(2009) Carol F. Lippa et al.   ARCHIVES OF NEUROLOGY

Colocalization of Transactivation-Responsive DNA-Binding Protein 43 and Huntingtin in Inclusions of Huntington Disease

(2008) Claudia Schwab et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies

(2008) Kunihiro Uryu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuropathological Aspects of Alzheimer Disease, Parkinson Disease and Frontotemporal Dementia

(2008) Kurt A. Jellinger   Neurodegenerative Diseases