Review
Oncology
Mercedes Herrera-Juarez, Cristina Serrano-Gomez, Helena Bote-de-Cabo, Luis Paz-Ares
Summary: Precision oncology aims to design the best cancer treatment based on tumor biology. In NSCLC, patients with actionable genomic aberrations can benefit from targeted therapy, such as EGFR mutations and ALK rearrangements. Effective inhibitors have been developed for various druggable targets, leading to a paradigm shift in NSCLC treatment.
Review
Respiratory System
Elvin S. Cheng, Sam Egger, Suzanne Hughes, Marianne Weber, Julia Steinberg, Bayzidur Rahman, Heather Worth, Alberto Ruano-Ravina, Patrick Rawstorne, Xue Qin Yu
Summary: This study systematically reviewed and meta-analyzed the evidence of lung cancer risk in never-smokers associated with residential radon exposure, finding that in radon-prone areas, male never-smokers had a higher risk of lung cancer than female never-smokers. The study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers, indicating a higher risk for men among never-smokers in radon-prone areas.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Multidisciplinary Sciences
Xiaoyu Han, Jun Fan, Yumin Li, Yukun Cao, Jin Gu, Xi Jia, Yuhui Wang, Heshui Shi
Summary: This study aimed to identify the relationships of EGFR mutations and ALK status with CT characteristics in adenocarcinoma using a large patient cohort. The most significant independent prognostic factors of EGFR effective mutations were female sex, nonsmoker status, GGO air bronchograms, and pleural retraction. The use of CT features in combination with clinical variables showed superiority in predicting ALK positivity compared to using clinical variables alone.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Carolina Rosswog, Jana Fassunke, Angela Ernst, Birgid Schoemig-Markiefka, Sabine Merkelbach-Bruse, Christoph Bartenhagen, Maria Cartolano, Sandra Ackermann, Jessica Theissen, Mirjam Blattner-Johnson, Barbara Jones, Kathrin Schramm, Janine Altmueller, Peter Nuernberg, Monika Ortmann, Frank Berthold, Martin Peifer, Reinhard Buettner, Frank Westermann, Johannes H. Schulte, Thorsten Simon, Barbara Hero, Matthias Fischer
Summary: Genomic alterations of the ALK gene occur recurrently in neuroblastoma, with ALK mutations occurring in 10.5% of cases at diagnosis and increasing by 70% at relapse. However, the frequency of ALK amplifications does not change over the course of the disease. Regular monitoring of the genomic ALK status and evaluation of ALK-targeted treatment in intermediate-risk patients is recommended.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Siddhartha Devarakonda, Yize Li, Fernanda Martins Rodrigues, Sumithra Sankararaman, Humam Kadara, Chandra Goparaju, Irena Lanc, Kymberlie Pepin, Saiama N. Waqar, Daniel Morgensztern, Jeffrey Ward, Ashiq Masood, Robert Fulton, Lucinda Fulton, Michael A. Gillette, Shankha Satpathy, Steven A. Carr, Ignacio Wistuba, Harvey Pass, Richard K. Wilson, Li Ding, Ramaswamy Govindan
Summary: The study analyzed genomic and transcriptomic data from never-smoker lung adenocarcinoma samples, finding a high prevalence of clinically actionable driver alterations and potential role of germline variants in DNA repair genes and passive exposure to cigarette smoke in the pathogenesis of a subset of never-smoker LUADs. The findings also highlight the importance of obtaining biopsies with adequate cellularity for clinical genomic testing in these patients.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
M. Torres-Duran, M. T. Curiel-Garcia, A. Ruano-Ravina, M. Provencio, I Parente-Lamelas, J. Hernandez-Hernandez, A. Fernandez-Villar, J. M. Barros-Dios, M. Perez-Rios
Summary: Characteristics of SCLC in never-smokers were not associated with indoor radon exposure, and the survival rate of this aggressive lung cancer in never-smokers remains low.
Article
Biochemistry & Molecular Biology
Anna Buder, Ellen Heitzer, Julie Waldispuehl-Geigl, Sabrina Weber, Tina Moser, Maximilian J. Hochmair, Klaus Hackner, Peter Errhalt, Ulrike Setinek, Martin Filipits
Summary: The presence of resistance-related gene SCNAs in plasma before the initiation of osimertinib therapy is associated with lower response rate and shorter progression-free and overall survival.
Article
Respiratory System
Longyu Shan, Liang Zhang, Xiaolei Zhu, Zhilin Wang, Shaohan Fang, Junfeng Lin, Jianweng Wang, Ning Li, Hongming Liu, Xiaowen Zhang, Yihui Feng, Jingwei Liu, Jianyun Pan, Guanzhi Ye, Xiuyi Yu, Amanda Tufman, Alexander Katalinic, Torsten Goldmann, Frank Petersen, Jie Jiang, Guojun Geng, Xinhua Yu
Summary: In Chinese patients with non-small cell lung cancer (NSCLC), there are significant clinical differences between non-smokers and smokers, particularly in adenocarcinoma type, where non-smokers tend to be diagnosed at a younger age and have a lower risk of lymph node metastasis. However, these differences were not observed in squamous cell carcinoma type.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Chong Kin Liam, Chian Yih Yew, Yong Kek Pang, Chee Kuan Wong, Mau Ern Poh, Jiunn Liang Tan, Chun Ian Soo, Thian Chee Loh, Ka Kiat Chin, Vijayan Munusamy, Yong Sheng Liam, Nur Husna Ibrahim
Summary: This study investigated the relationship between PD-L1 expression, driver mutations, and cigarette smoking in non-small cell lung cancer (NSCLC). The results showed that high PD-L1 expression was more common in smokers, EGFR wild-type tumors, and heavy smokers.
Article
Oncology
Gang Xiao, Lifeng Li, Guilong Tanzhu, Zhiyuan Liu, Xuan Gao, Xin Wan, Desheng Xiao, Liu Chen, Xuefeng Xia, Rongrong Zhou
Summary: This study found that lung adenocarcinomas (LUAD) with EGFR-positive and ALK-positive had a suppressive tumor immune microenvironment (TIME) and were less responsive to immunotherapy. The TIME in patients with EGFR/ALK-positive LUAD brain metastases (BMs) was different from that in primary lung cancer. Evaluating the immune characteristics of LUAD BMs is important for clinical treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Gabriele Gamerith, Marcel Kloppenburg, Finn Mildner, Arno Amann, Sabine Merkelbach-Bruse, Carina Heydt, Janna Siemanowski, Reinhard Buettner, Michael Fiegl, Claudia Manzl, Georg Pall
Summary: This study analyzed the genetic landscape of lung cancer patients exposed to radon and found an increased alteration in the MET gene, highlighting the importance of routine testing and potential for more effective treatment in this specific subgroup.
Article
Public, Environmental & Occupational Health
Rachael L. Murray, Emma O'Dowd
Summary: Despite the decrease in smoking rates since 2000, smoking remains a significant risk factor for premature mortality and lung cancer. Continuing to smoke after a lung cancer diagnosis is associated with increased mortality and tumor recurrence. A recent meta-analysis indicates that quitting smoking around the time of lung cancer diagnosis is associated with improved survival.
LANCET PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Haoyue Hu, Songtao Tan, Meng Xie, Peng Guo, Qiang Yu, Juan Xiao, Kangrui Zhao, Qiong Liao, Yi Wang
Summary: In non-small cell lung cancer, concurrent genetic alterations of epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are rare, but their clinical and pathological characteristics are not well-defined, and the optimal treatment approach remains controversial. This report presents a case of stage IV lung adenocarcinoma with both EGFR and ALK mutations, along with high PD-L1 expression. The patient initially received treatment with EGFR tyrosine kinase inhibitors (TKIs), but the disease progressed, and regression was achieved following a switch to ALK-TKI therapy and local radiotherapy. Our report also provides a comprehensive summary of the clinical and pathological features, as well as treatment strategies, for NSCLC patients with concurrent EGFR mutation and ALK rearrangement.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Alberto Ruano-Ravina, Leonor Varela Lema, Marta Garcia Talavera, Montserrat Garcia Gomez, Santiago Gonzalez Munoz, Maria Isolina Santiago-Perez, Julia Rey-Brandariz, Juan Barros-Dios, Monica Perez-Rios
Summary: The study estimated the lung cancer mortality attributable to residential radon exposure in Spain and its Autonomous Regions. The results showed that correction for dwelling height was essential for providing reliable estimates, with the highest population attributable fractions in Galicia, Extremadura, and the Canary Islands.
ENVIRONMENTAL RESEARCH
(2021)
Article
Peripheral Vascular Disease
Hengqiu He, Wendi Yang, Yusheng Huang, Xiaoyue Zhang, Yuan Peng, Zhenzhou Yang
Summary: This case study highlights the significance of using antiangiogenic therapy combined with chemotherapy in achieving sustained remission in advanced lung adenocarcinoma patients with concurrent ALK/EGFR mutations and extremely high PD-L1 expression. The use of anti-angiogenics should not be underestimated in this era of targeted therapy and checkpoint inhibitors.
Article
Allergy
B. Barroso, M. Valverde-Monge, I Alobid, J. M. Olaguibel, M. J. Rial, S. Quirce, E. Arismendi, P. Barranco, D. Betancor, I Bobolea, B. Cardaba, Cruz M. J. Carmona, E. Curto, J. Dominguez-Ortega, F. Gonzalez-Barcala, C. Martinez-Rivera, I Mahillo-Fernandez, X. Munoz, C. Picado, V Plaza, Rodrigo J. M. Munoz, L. Soto-Retes, A. Valero, V del Pozo, J. Mullol, J. Sastre
Summary: This real-world study found that biological treatments, including omalizumab, mepolizumab, reslizumab, and benralizumab, can improve olfaction in patients with severe asthma and associated CRSwNP. There were no significant differences in olfaction improvement between different biologic drugs, with factors such as atopy, steroid use, and polyp size influencing the improvement. The study also showed no differences in olfaction improvement between N-ERD and non-N-ERD groups.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Sara Vazquez-Mera, Laura Martelo-Vidal, Pablo Miguens-Suarez, Paula Saavedra-Nieves, Pilar Arias, Coral Gonzalez-Fernandez, Mar Mosteiro-Anon, Maria Dolores Corbacho-Abelaira, Marina Blanco-Aparicio, Paula Mendez-Brea, Francisco Javier Salgado, Juan Jose Nieto-Fontarigo, Francisco Javier Gonzalez-Barcala
Summary: The study evaluated specific T-cell miRNA signatures in serum exosomes from different subgroups of asthmatic patients, and identified miRNAs related to asthma phenotype and severity.
Letter
Respiratory System
Maria Estrella Lopez-Pardo, Cristina Candal-Represas, Luis Valdes-Cuadrado, Cristina Represas-Represas, Alberto Ruano-Ravina, Monica Perez-Rios
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Respiratory System
Francisco Javier Alvarez-Gutierrez, Marina Blanco-Aparicio, Francisco Casas-Maldonado, Vicente Plaza, Francisco Javier Gonzalez-Barcala, Jose angel Carretero-Gracia, Manuel Castilla-Martinez, Carolina Cisneros, David Diaz-Perez, Christian Domingo-Ribas, Eva Martinez-Moragon, Xavier Munoz, Alicia Padilla-Galo, Miguel Perpina-Tordera, Gregorio Soto-Campos
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Editorial Material
Allergy
C. Betancor, J. M. Olaguibel, J. M. Rodrigo-Munoz, M. J. Alvarez Puebla, E. Arismendi, P. Barranco, B. Barroso, I Bobolea, B. Cardaba, M. J. Cruz, E. Curto, V Del Pozo, J. Dominguez-Ortega, F. J. Gonzalez-Barcala, J. A. Luna-Porta, C. Martinez-Rivera, J. Mullol, X. Munoz, C. Picado, V Plaza, S. Quirce, M. J. Rial, L. Soto-Retes, A. Valero, M. Valverde-Monge, J. Sastre
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Lucia Robado de Lope, Estela Sanchez-Herrero, Roberto Serna-Blasco, Mariano Provencio, Atocha Romero
Summary: Cancer is considered an evolutionary disease where tumor cells adapt to the environment and eventually form metastasis. Communication between tumor cells and the surrounding microenvironment via extracellular vesicles (EVs) is crucial for the success of the metastatic process. Recent studies suggest that tumor-derived EVs not only modify the microenvironment to facilitate tumor progression but also induce malignant transformation in cells outside the primary tumor. Further research is needed to understand the role of EVs in cancer progression and metastasis, which may have implications for novel cancer treatments.
MOLECULAR ONCOLOGY
(2023)
Article
Respiratory System
Marcos Matabuena, Francisco Javier Salgado, Juan Jose Nieto-Fontarigo, Maria J. Alvarez-Puebla, Ebymar Arismendi, Pilar Barranco, Irina Bobolea, Maria L. Caballero, Jose Antonio Canas, Blanca Cardaba, Maria Jesus Cruz, Elena Curto, Javier Dominguez-Ortega, Juan Alberto Luna, Carlos Martinez-Rivera, Joaquim Mullol, Xavier Munoz, Javier Rodriguez-Garcia, Jose Maria Olaguibel, Cesar Picado, Vicente Plaza, Santiago Quirce, Manuel J. Rial, Christian Romero-Mesones, Beatriz Sastre, Lorena Soto-Retes, Antonio Valero, Marcela Valverde-Monge, Victoria Del Pozo, Joaquin Sastre, Francisco Javier Gonzalez-Barcala
Summary: This study used unsupervised cluster analysis to identify four asthma phenotypes, including adult-onset, adolescent-onset, middle-age-onset, and elderly-onset. These phenotypes differ from each other in terms of lung function, age of onset, BMI, atopy, asthma severity, exacerbations, control, social class, smoking, and nasal polyps.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Review
Allergy
Christian Calvo-Henriquez, Paula Rodriguez-Rivas, Miguel Mayo-Yanez, Francisco J. Gonzalez-Barcala, Borja Boronat-Catala, Silvia Martins-Neves, Gabriel Martinez-Capoccioni, Carlos Martin-Martin
Summary: This study aimed to review the literature and investigate whether allergic rhinitis (AR) contributes to the development of dental caries. The results showed a possible association between AR and dental caries, but more research is needed to confirm this relationship.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)
Review
Allergy
Angelica Tiotiu, Miguel-Angel Martinez-Garcia, Paula Mendez-Brea, Iria Roibas-Veiga, Francisco-Javier Gonzalez-Barcala
Summary: There is a relationship between asthma and bronchiectasis, with some asthma patients being the cause of bronchiectasis. Both diseases share similar pathological mechanisms and comorbidities, and have similar clinical presentations, but longitudinal studies confirming asthma as the cause of bronchiectasis are still lacking.
Editorial Material
Respiratory System
Heidi Makrinioti, Angelica Tiotiu, Francisco-Javier Gonzalez-Barcala
Article
Virology
Irene Visos-Varela, Maruxa Zapata-Cachafeiro, Samuel Pintos-Rodriguez, Rosendo Bugarin-Gonzalez, Francisco Javier Gonzalez-Barcala, Maria T. Herdeiro, Maria Pineiro-Lamas, Adolfo Figueiras, Angel Salgado-Barreira
Summary: This study evaluates the effect of statin use on patients with COVID-19 and finds that chronic use of atorvastatin and simvastatin is associated with a decreased risk of hospitalization, mortality, and susceptibility to the virus.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Alberto Ruano-Ravina, Lucia Martin-Gisbert, Karl Kelsey, Monica Perez-Rios, Cristina Candal-Pedreira, Julia Rey-Brandariz, Leonor Varela-Lema
Summary: The aim of this study is to provide an overview of research on indoor radon and lung cancer, with a focus on Spanish investigations. Early studies established the link between radon and lung cancer, and later case-control studies confirmed this association in the general population. Spain has contributed extensive evidence, including multiple studies exploring various aspects such as the effect of radon on never-smokers, molecular pathways, survival rates, mortality burden, and occupational exposure. The causal association between radon and lung cancer is well-established, but further research is needed to understand the potential molecular pathways and other health effects.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Respiratory System
Cristina Candal-Pedreira, Alberto Ruano-Ravina, Virginia Calvo de Juan, Manuel Cobo, Jose Manuel Trigo, Enric Carcereny, Marc Cucurull, Rafael Lopez Castro, Eduardo Solis Garcia, Amparo Sanchez-Gastaldo, Bartomeu Massuti, Delvys Rodriguez-Abreu, Anna Estival, Maria Guirado Risueno, Maria Pamies Ramon, Rosario Garcia Campelo, Guillermo Alonso-Jaudenes, Carlos Camps, Edel del Barco Morillo, Clara Gonzalez Ojea, Manuel Domine, Alfredo Sanchez-Hernandez, Joaquim Bosch-Barrera, Maria Angeles Sala Gonzalez, Mariano Provencio
Summary: Over one-third of lung cancer cases in Spain cannot be detected through screening due to not meeting the most recent inclusion criteria. The degree of fulfilment in a potential nationwide screening programme should be analyzed, with the aim of establishing inclusion criteria in line with each country's context.
Article
Medical Ethics
Cristina Candal-Pedreira, Ali Ghaddar, Monica Perez-Rios, Leonor Varela-Lema, Carlos Alvarez-Dardet, Alberto Ruano-Ravina
Summary: This study examines the perceptions, attitudes, and experiences of Spanish researchers regarding scientific misconduct in the field of biomedicine. The results show a high frequency of scientific misconduct among Spanish biomedical researchers, with 43.3% admitting to engaging in some form of misconduct. False authorship is the most common type of misconduct. There are variations in the types of misconduct based on gender and the type of research institution.
ACCOUNTABILITY IN RESEARCH-ETHICS INTEGRITY AND POLICY
(2023)
Article
Environmental Sciences
Lucia Martin-Gisbert, Cristina Candal-Pedreira, Marta Garcia-Talavera San Miguel, Monica Perez-Rios, Juan Barros-Dios, Leonor Varela-Lema, Alberto Ruano-Ravina
Summary: The study aimed to describe workplace radon exposure in Spain and its influencing factors. The results showed that approximately one-fifth of workplaces in radon prone areas had radon concentrations above the standard limit of 300 Bq/m3. Radon concentration varied significantly by floor level, working sector, and location. The highest radon concentrations were found in the Education & Culture sector.
ENVIRONMENTAL RESEARCH
(2023)