Letter
Medicine, General & Internal
Shuvadeep Ganguly, Ajay Gogia
Summary: In the KEYNOTE-522 trial, the addition of Pembrolizumab to neoadjuvant chemotherapy improved pathological complete response rate in early triple-negative breast cancer patients and also improved event-free survival. However, this improvement was predominantly observed in patients who did not achieve a pathological complete response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Murielle Murielle Beaubrun-Renard, Jacqueline Veronique-Baudin, Jonathan Macni, Stephen Ulric-Gervaise, Thierry Almont, Aude Aline-Fardin, Nathalie Grossat, Cristina Furtos, Patrick Escarmant, Vincent Vinh-Hung, Stefanos Bougas, Andre Cabie, Clarisse Joachim
Summary: This study investigated the survival and prognostic factors of women with breast cancer in Martinique, a French overseas territory, from 2008 to 2017. The findings showed overall good prognosis for breast cancer patients and identified several factors associated with increased risk of death, including metastatic disease, triple negative breast cancer, HR+/HER2- status, and age over 75.
Article
Medicine, General & Internal
J. Cortes, H. S. Rugo, D. W. Cescon, S-A Im, M. M. Yusof, C. Gallardo, O. Lipatov, C. H. Barrios, J. Perez-Garcia, H. Iwata, N. Masuda, M. Torregroza Otero, E. Gokmen, S. Loi, Z. Guo, X. Zhou, V Karantza, W. Pan, P. Schmid
Summary: The addition of pembrolizumab to chemotherapy significantly improves overall survival in patients with advanced triple-negative breast cancer whose tumors express PD-L1 with a CPS of 10 or more.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Jose P. Leone, Noah Graham, Julieta Leone, Sara M. Tolaney, Bernardo A. Leone, Rachel A. Freedman, Michael J. Hassett, Carlos T. Vallejo, Eric P. Winer, Nancy U. Lin, Nabihah Tayob
Summary: This study developed a tool called "ESTIMATE-TN" to assess the risk of breast cancer-specific mortality (BCSM), non-BCSM, and all-cause mortality in non-metastatic triple-negative breast cancer (TNBC) patients. The tool allows input of patient and tumor characteristics and provides a nonparametric estimate of cumulative risks using Gray's subdistribution method.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jie Ping, Shuya Huang, Jie Wu, Pingping Bao, Timothy Su, Kai Gu, Hui Cai, Xingyi Guo, Loren Lipworth, William J. Blot, Wei Zheng, Qiuyin Cai, Xiao-Ou Shu
Summary: Long intergenic non-coding RNAs (lincRNAs) have been identified as important regulators in breast cancer, including the triple-negative subtype. Using RNA-Seq data from 200 TNBC patients, 25 lincRNAs were associated with overall survival and 61 with disease-free survival. Two specific lincRNAs, LINC01270 and LINC00449, were significantly associated with worse overall survival and DFS, and showed higher expression in tumor tissues compared to normal tissues. In vitro experiments suggested that these lincRNAs may serve as prognostic biomarkers for TNBC.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Yinggang Xu, Weiwei Zhang, Jinzhi He, Ye Wang, Rui Chen, Wenjie Shi, Xinyu Wan, Xiaoqing Shi, Xiaofeng Huang, Jue Wang, Xiaoming Zha
Summary: A nomogram was constructed to predict the overall survival (OS) of triple-negative apocrine carcinoma (TNAC) patients. The nomogram showed good discrimination and clinical utility in evaluating patient prognosis and guiding treatment decisions.
Article
Cell Biology
Lin Jiang, Chao You, Yi Xiao, He Wang, Guan-Hua Su, Bing-Qing Xia, Ren-Cheng Zheng, Dan-Dan Zhang, Yi-Zhou Jiang, Ya-Jia Gu, Zhi-Ming Shao
Summary: In this study, we extracted radiomic features from TNBC patients and constructed a breast cancer radiomic dataset and a TNBC radiogenomic dataset. By analyzing these datasets, we identified a radiomic feature that can predict the recurrence and overall survival of TNBC, and found that peritumoral heterogeneity is associated with immune suppression and upregulated fatty acid synthesis.
CELL REPORTS MEDICINE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Alexandre de Nonneville, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier, Francois Bertucci
Summary: This study demonstrates the critical role of WEE1 in triple negative breast cancer, its pejorative prognostic value, and its correlation with biomarkers of sensitivity to WEE1 inhibitors.
Article
Cell Biology
Aeson Chang, Edoardo Botteri, Ryan D. Gillis, Lukas Lofling, Caroline P. Le, Alexandra I. Ziegler, Ni-Chun Chung, Matthew C. Rowe, Stewart A. Fabb, Brigham J. Hartley, Cameron J. Nowell, Sasagu Kurozumi, Sara Gandini, Elisabetta Munzone, Emilia Montagna, Nina Eikelis, Sarah E. Phillips, Chikako Honda, Kei Masuda, Ayaka Katayama, Tetsunari Oyama, Steve W. Cole, Gavin W. Lambert, Adam K. Walker, Erica K. Sloan
Summary: We found a relationship between beta-blocker use and anthracycline chemotherapy in protecting against TNBC progression, disease recurrence, and mortality. Beta-blockade improved the efficacy of anthracycline chemotherapy in TNBC mouse models by reducing metastatic development. Anthracycline chemotherapy increased sympathetic nerve fiber activity and norepinephrine concentration in mammary tumors, but this effect can be overcome by inhibiting beta 2-adrenergic signaling in the tumor microenvironment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Min Huang, Peter A. Fasching, Amin Haiderali, Weiguang Xue, Wilbur Pan, Vassiliki Karantza, Fan Yang, James Truscott, Yiqiao Xin, Joyce O'Shaughnessy
Summary: This study evaluated the use of event-free survival (EFS) as a surrogate outcome for overall survival (OS) in neoadjuvant therapy for early-stage triple-negative breast cancer (eTNBC). The results showed that 3-year EFS can accurately predict 5-year OS, and there is a significant association between the treatment effect on EFS and OS. Therefore, EFS can be considered a valid surrogate for assessing overall survival in eTNBC patients following neoadjuvant therapy.
Article
Medicine, General & Internal
Miquel Ensenyat-Mendez, Maria Solivellas-Pieras, Pere Llinas-Arias, Sandra Iniguez-Munoz, Jennifer L. Baker, Diego M. Marzese, Maggie L. DiNome
Summary: This study aims to investigate the epigenetic differences in triple-negative breast cancer (TNBC) of younger African American females and understand the clinical disparities in this patient group. The results suggest that TNBC of younger African American females may have distinct epigenetic characteristics and provide novel insights into the molecular alterations associated with TNBC in this population.
Article
Medicine, General & Internal
Wei-Xun Lin, Yan-Na Xie, Yao-Kun Chen, Jie-Hui Cai, Juan Zou, Jie-Hua Zheng, Yi-Yuan Liu, Zhi-Yang Li, Ye-Xi Chen
Summary: This study aimed to construct and validate a prognostic nomogram for Chinese TNBC patients after surgery. The nomogram, incorporating age, marital status, tumor characteristics, and pathological factors, showed superior predictive ability compared to the traditional TNM staging system. The risk stratification model based on the nomogram accurately categorized patients into different prognostic groups.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Oncology
Gang Ji, Longlong Bao, Qianlan Yao, Jing Zhang, Xiaoli Zhu, Qianming Bai, Zhiming Shao, Wentao Yang, Xiaoyan Zhou
Summary: The prevalence of germline and tumor BRCA1/2 pathogenic variants in Chinese triple-negative breast cancer (TNBC) patients under 55 years old is high, with 21.0% germline and 25% tumor PV carriers. Patients with tumor BRCA1/2 PVs showed significantly improved survival outcomes. There was a significant correlation between family history and germline BRCA1/2 PVs among these patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Xiaopan Zou, Yan Liu, Jun Di, Wei Wei, Nobumoto Watanabe, Jiang Li, Xiaomeng Li
Summary: This study found that ZMIZ2 is upregulated in TNBC tissues and is associated with its poor prognosis. ZMIZ2 may promote TNBC progression by promoting the expression of its target genes and affecting the corresponding pathways. ZMIZ2 may serve as a promising target for future TNBC treatments.
CANCER CELL INTERNATIONAL
(2022)
Letter
Medicine, General & Internal
Ryan Sun, Lee-Jen Wei
Summary: This article discusses the clinical benefits of pembrolizumab combined with chemotherapy in patients with triple-negative breast cancer. The authors suggest that both hazard values and ratios should be considered when evaluating clinical benefits.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Elizabeth Elimimian, Leah Elson, Nadeem Bilani, Safa E. Farrag, Alok Kumar Dwivedi, Rebecca Pasillas, Zeina A. Nahleh
INTEGRATIVE CANCER THERAPIES
(2020)
Article
Oncology
E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett, Z. A. Nahleh
Article
Oncology
Nadeem Bilani, Leah Elson, Hong Liang, Elizabeth Blessing Elimimian, Zeina Nahleh
Summary: This large retrospective study revealed that clinicopathologic characteristics and social determinants were associated with the use of surgery in patients with de novo metastatic breast cancer, and surgery, particularly resection of the primary tumor and distant site resection, significantly improved overall survival.
CLINICAL BREAST CANCER
(2021)
Correction
Oncology
E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett, Z. A. Nahleh
Review
Hematology
Elizabeth B. Elimimian, Nadeem Bilani, Maria J. Diacovo, Skirmante Sirvaitis, Chieh Lin Fu
Summary: Waldenstrom's macroglobulinemia (WM) is a rare indolent B-cell non-Hodgkin lymphoma with low mortality from histologic transformation. A case study demonstrates that untreated WM can transform after a decade of stability, leading to rapidly deteriorating clinical outcomes. Late transformation is associated with poor prognosis, and further molecular investigation is needed to clarify the clonal relationship in such cases.
JOURNAL OF HEMATOLOGY
(2021)
Article
Andrology
Elizabeth B. Elimimian, Leah Elson, Hong Li, Hong Liang, Nadeem Bilani, Emily C. Zabor, Abby Statler, Zeina Nahleh
Summary: This study analyzed the clinicopathologic characteristics and survival rates of male breast cancer patients using the National Cancer Database, finding that male patients with breast cancer are typically older, have more comorbidities, and present with more advanced disease compared to female patients, resulting in lower survival rates.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Medicine, Research & Experimental
Nadeem Bilani, Leah Elson, Charles Szuchan, Elizabeth Elimimian, Mustafa Saleh, Zeina Nahleh
Summary: Studies have shown that vitamin D plays a critical role in tumor suppression mechanisms, affecting tumor gene expression, invasiveness, and sensitivity to chemotherapy. These newly-identified pathways are of interest for further research to explore the role of vitamin D supplementation in precision treatment for breast, colon, and skin cancers.
Article
Cardiac & Cardiovascular Systems
Charles Szuchan, Leah Elson, Evan Alley, Kevin Leung, Antonio Lewis Camargo, Elizabeth Elimimian, Zeina Nahleh, Diego Sadler
EUROPEAN HEART JOURNAL-CASE REPORTS
(2020)
Article
Oncology
Nadeem Bilani, Leah Elson, Hong Liang, Elizabeth Blessing Elimimian, Rafael Arteta-Bulos, Zeina Nahleh
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2020)
Article
Medicine, General & Internal
Nadeem Bilani, Leah Elson, Diane Carlson, Elizabeth Blessing Elimimian, Zeina Nahleh
CASE REPORTS IN MEDICINE
(2020)
Article
Oncology
Nadeem Bilani, Emily C. Zabor, Leah Elson, Elizabeth B. Elimimian, Zeina Nahleh
JOURNAL OF CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
Zeina A. Nahleh, Elizabeth B. Elimimian, Leah C. Elson, Brian Hobbs, Wei Wei, Cassann N. Blake
BREAST CANCER-BASIC AND CLINICAL RESEARCH
(2020)
Article
Oncology
Nadeem Bilani, Leah Elson, Felipe Martinez, Diego Sadler, Zeina Nahleh, Elizabeth Elimimian, Evan Alley
CASE REPORTS IN ONCOLOGY
(2020)
Editorial Material
Ophthalmology
Carol L. Shields, Elizabeth B. Elimimian
INDIAN JOURNAL OF OPHTHALMOLOGY
(2018)