In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents

Cardiovascular diseases (CVDs) are among the leading causes of mortality and morbidity worldwide. Nitric oxide (NO) is a signalling molecule that plays a vital role in protecting and regulating cardiovascular function and homeostasis. Despite several successful outcomes of exogenous supplementation of NO for cardiovascular disease therapy, a great challenge lies in controlled and long-term delivery due to the short half-life and instability of NO. Recently, increasing attention has been paid to the in situ conversion of endogenous NO donors catalysed by functional surfaces. Based on bioinspired and biomimicking strategies, a series of surface functionalization methods for cardiovascular stents has been successfully developed. By further combining NO catalysis with other biofunctionalities, improved endothelium healing and long-term patency can be anticipated.

Automated summary

Cardiovascular diseases are a leading cause of mortality worldwide, and nitric oxide plays a vital role in regulating cardiovascular function. Research on the in situ conversion of endogenous NO donors catalysed by functional surfaces for cardiovascular stents has shown promising results in improving endothelium healing and long-term patency.