Review
Endocrinology & Metabolism
Vicente A. Benites-Zapata, Felipe L. Ignacio-Cconchoy, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Percy Herrera-Anazco
Summary: This study reviewed existing studies to assess differences in serum vitamin B12 levels among patients with and without thyroid disorders (TD), frequency of vitamin B12 deficiency, and presence of anti-parietal cell antibodies in TD patients. Results showed that patients with hypothyroidism had lower vitamin B12 levels compared to healthy participants, while no significant differences were observed in patients with hyperthyroidism, autoimmune thyroid disease (AITD), or subclinical hypothyroidism (SH). The frequencies of vitamin B12 deficiency were 27%, 6%, 27%, and 18% for hypothyroidism, hyperthyroidism, SH, and AITD respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Junli Zou, Huiyong Peng, Yingzhao Liu
Summary: Exosomes are small extracellular vesicles released from cells that contain various bioactive molecules and play a crucial role in cell-to-cell communication. Studies have shown that exosomes are involved in the pathogenesis of autoimmune thyroid diseases, but further exploration is still needed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Olivia Trummer, Ines Foessl, Natascha Schweighofer, Edi Arifi, Christoph W. Haudum, Sharmaine Reintar, Stefan Pilz, Verena Theiler-Schwetz, Christian Trummer, Andreas Zirlik, Albrecht Schmidt, Caterina Colantonio, Ewald Kolesnik, Nicolas Verheyen, Thomas R. Pieber, Barbara Obermayer-Pietsch
Summary: The aim of this study was to assess the differential expression of 9 selected miRNAs related to immunological functions between patients with Hashimoto's thyroiditis (HT) and healthy controls. The results showed that miR21-5p, miR-22-3p, miR-22-5p, miR-142-3p, miR-146a-5p, miR-301-3p, and miR-451 were significantly upregulated in HT patients and altered expressions of miR-22-5p and miR-142-3p were associated with higher levels of thyroid antibodies.
Article
Endocrinology & Metabolism
Pablo Sacristan-Gomez, Ana Serrano-Somavilla, Roberto Gonzalez-Amaro, Rebeca Martinez-Hernandez, Monica Marazuela
Summary: This study investigated the expression levels of HDACs and Tip60 HAT in the thyroid gland and immune cells of patients with AITD. The findings showed a significant increase in HDAC9 expression in AITD patients, while Tip60 expression was reduced in patients with Hashimoto thyroiditis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Pin Li, Shuang Zhang, Ningzi Zang, Chengjun Gong, Nan Li, Xiao Yang, Jing Lv, Tianshu Gao
Summary: This article presents a bibliometric analysis of the literature on autoimmune thyroid disease (AITD). It identifies the research hotspots and provides a theoretical basis for future research in the field.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Immunology
Yu-tian Cao, Kai-yu Zhang, Jing Sun, Yan Lou, Tian-su Lv, Xinyi Yang, Wen-hui Zhang, Jiang-yi Yu, Qi-biao Wu, Xi-qiao Zhou
Summary: Platelet index abnormalities are present in patients with autoimmune thyroid disease (AITD), with increased platelet count (PLT) and mean platelet volume (MPV) in AITD patients compared to healthy controls. However, no significant difference was found in platelet distribution width (PDW). The differences in PLT were mainly observed in Hashimoto's thyroiditis (HT) and hypothyroid groups, while the differences in MPV were mainly observed in Graves' disease (GD) and hyperthyroid groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tatjana Zake, Ieva Kalere, Sabine Upmale-Engela, Simons Svirskis, Gita Gersone, Andrejs Skesters, Valerija Groma, Ilze Konrade
Summary: The study found no significant differences in Th17-related cytokine levels in newly diagnosed GD and HT patients. In HT patients, IL-17a levels were positively correlated with other cytokines, while in GD patients, IL-17a levels were positively correlated with IL-22 and IL-23. Plasma selenium levels were negatively correlated with antibody titers in HT patients.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Review
Nutrition & Dietetics
Jiaxin Zhou, Wenfen Zhang, Zhiwen Cao, Shaoyan Lian, Jieying Li, Jiaying Nie, Ying Huang, Ke Zhao, Jiang He, Chaoqun Liu
Summary: This study conducted a comprehensive analysis of the association between selenium and neurodegenerative diseases (NDs). It found that AD patients had significantly lower selenium concentrations compared with healthy individuals, while no significant association was observed for the other four diseases. More research is needed for further understanding and treatment of NDs.
Review
Nutrition & Dietetics
Meire Ellen Pereira, Julia Vicentin Souza, Maria Eduarda Andrade Galiciolli, Fernanda Sare, Giovanna Scorsin Vieira, Isabeli Lopes Kruk, Claudia Sirlene Oliveira
Summary: Selenium (Se) supplementation is a good alternative for improving Se levels and glutathione peroxidase (GPX) activity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), and it can also improve some cognitive test results.
Review
Nutrition & Dietetics
Marianna Minnetti, Valentina Sada, Tiziana Feola, Elisa Giannetta, Carlotta Pozza, Daniele Gianfrilli, Andrea M. Isidori, Alessia Cozzolino
Summary: Selenium is an essential trace element that plays a crucial role in thyroid metabolism and the immune system. Supplementing with selenium may improve inflammation in patients with thyroiditis and potentially affect thyroid function during pregnancy. However, further research is needed to confirm the effectiveness of selenium supplementation in pregnant women with thyroiditis.
Review
Endocrinology & Metabolism
Boshen Gong, Chuyuan Wang, Fanrui Meng, Haoyu Wang, Bo Song, Yang Yang, Zhongyan Shan
Summary: Autoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Recent studies have shown altered gut microbiota composition in patients with AITD, with changes in alpha diversity and abundance of specific gut microbiota. The meta-analysis indicated an association between AITD and alteration of microbiota composition at the family, genus, and species levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Jen-Fu Huang, Chih-Po Hsu, Chun-Hsiang Ouyang, Chi-Tung Cheng, Chia-Cheng Wang, Chien-Hung Liao, Yu-Tung Wu, Chi-Hsun Hsieh
Summary: This study aimed to assess the effect of selenium supplementation on the prognosis of trauma patients. The meta-analysis showed that selenium supplementation was associated with a lower mortality rate and shorter hospital stay, but did not have a statistically significant benefit on the incidence of infectious complications.
Review
Endocrinology & Metabolism
Dania Akeil Abed Alkader, Naweedullah Asadi, Uzma Solangi, Ransherjit Singh, Sayed Farhad Rasuli, Muhammad Jawad Farooq, F. N. U. Raheela, Radeyah Waseem, Syed Mujahid Gilani, Kiran Abbas, Moiz Ahmed, Desmond Boakye Tanoh, Hussain Haider Shah, Ayusha Dulal, Muhammad Sheheryar Hussain, Abdul Subhan Talpur
Summary: There is a significant difference in the diversity and composition of the gut microbiota in patients with autoimmune thyroid diseases (AITDs).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Haoting Zhan, Haolong Li, Chenxi Liu, Linlin Cheng, Songxin Yan, Yongzhe Li
Summary: Circulating VEGF levels are associated with autoimmune diseases and may predict disease manifestations and activity in patients, indicating potential therapeutic implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Jiahui Ouyang, Yajie Cai, Yewen Song, Zhuye Gao, Ruina Bai, Anlu Wang
Summary: This meta-analysis examined the effects of selenium supplementation on insulin resistance, glucose homeostasis, and lipid profiles in patients with cardiometabolic diseases. The results suggested that selenium supplementation can reduce insulin levels, insulin resistance, and increase high-density lipoprotein cholesterol levels. However, it had no significant effect on other markers.
