The Development of a Juvenile Porcine Augmented Renal Clearance Model Through Continuous Infusion of Lipopolysaccharides: An Exploratory Study

Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model

(2021) Laura Dhondt et al.   Frontiers in Pharmacology

Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

(2020) Laura Dhondt et al.   Frontiers in Pharmacology

Augmented Renal Clearance and How to Augment Antibiotic Dosing

(2020) Iris H. Chen et al.   Antibiotics-Basel

Augmented Renal Clearance

(2019) Aaron M. Cook et al.   PHARMACOTHERAPY

Augmented renal clearance: a common condition in critically ill children

(2019) Tatjana Van Der Heggen et al.   PEDIATRIC NEPHROLOGY

Development and validation of an ultra-high performance liquid chromatography–tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma

(2019) Laura Dhondt et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Comparative physiology of glomerular filtration rate by plasma clearance of exogenous creatinine and exo-iohexol in six different avian species

(2019) Elke Gasthuys et al.   Scientific Reports

Modulation of the acute phase response following a lipopolysaccharide challenge in pigs supplemented with an all-natural Saccharomyces cerevisiae fermentation product

(2018) Nicole C. Burdick Sanchez et al.   Livestock Science

The global burden of paediatric and neonatal sepsis: a systematic review

(2018) Carolin Fleischmann-Struzek et al.   Lancet Respiratory Medicine

Phytosterols Synergize With Endotoxin to Augment Inflammation in Kupffer Cells but Alone Have Limited Direct Effect on Hepatocytes

(2017) Gregory Guthrie et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Repetitive urine and blood sampling in neonatal and weaned piglets for pharmacokinetic and pharmacodynamic modelling in drug discovery: a pilot study

(2017) Elke Gasthuys et al.   LABORATORY ANIMALS

Augmented Renal Clearance Using Population-Based Pharmacokinetic Modeling in Critically Ill Pediatric Patients*

(2017) Sean N. Avedissian et al.   Pediatric Critical Care Medicine

Augmented Renal Clearance in Critically Ill Pediatric Patients

(2017) John N. van den Anker et al.   Pediatric Critical Care Medicine

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Potential Use of Piglets as Human Pediatric Surrogate for Preclinical Pharmacokinetic and Pharmacodynamic Drug Testing

(2016) Elke Gasthuys et al.   CURRENT PHARMACEUTICAL DESIGN

Augmented renal clearance in non–critically ill abdominal and trauma surgery patients is an underestimated phenomenon

(2016) Peter Declercq et al.   Journal of Trauma and Acute Care Surgery

Augmented Renal Clearance in Patients With Febrile Neutropenia is Associated With Increased Risk for Subtherapeutic Concentrations of Vancomycin

(2016) Keita Hirai et al.   THERAPEUTIC DRUG MONITORING

Augmented renal clearance in non–critically ill abdominal and trauma surgery patients is an underestimated phenomenon

(2016) Peter Declercq et al.   Journal of Trauma and Acute Care Surgery

Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs

(2015) Lei Wang et al.   AMINO ACIDS

Augmented Renal Clearance Implies a Need for Increased Amoxicillin-Clavulanic Acid Dosing in Critically Ill Children

(2015) Pieter A. J. G. De Cock et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation

(2015) Heidi Wyns et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

(2015) H. Wyns et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Fluid Resuscitation in Sepsis

(2014) Bram Rochwerg et al.   ANNALS OF INTERNAL MEDICINE

Systemic E. coli lipopolysaccharide but not deoxynivalenol results in transient leukopenia and diminished metabolic activity of peripheral blood mononuclear cells ex vivo

(2014) Jeannette Kluess et al.   Mycotoxin Research

Plasma NGAL for the Diagnosis of AKI in Patients Admitted from the Emergency Department Setting

(2013) K. Soto et al.   Clinical Journal of the American Society of Nephrology

Endotoxin Tolerance Variation over 24 h during Porcine Endotoxemia: Association with Changes in Circulation and Organ Dysfunction

(2013) Markus Castegren et al.   PLoS One

Introduction to Drug Pharmacokinetics in the Critically III Patient

(2012) Brian S. Smith et al.   CHEST

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

(2012) Linda Engström et al.   ENDOCRINOLOGY

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years

(2012) Ibrahim Ince et al.   THERAPEUTIC DRUG MONITORING

In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration

(2012) Sharla M. Peters et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Erythropoietin does not attenuate renal dysfunction or inflammation in a porcine model of endotoxemia

(2011) C. SØLLING et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Pathophysiologic and Immunologic Changes in a Canine Endotoxemia over a Period of 24 Hours

(2011) Do-Hyeon YU et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Development and validation of a tissue cage model of acute inflammation in the cat

(2011) L. PELLIGAND et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Implications of augmented renal clearance in critically ill patients

(2011) Andrew A. Udy et al.   Nature Reviews Nephrology

Endothelin Receptor A Antagonism Attenuates Renal Medullary Blood Flow Impairment in Endotoxemic Pigs

(2011) Johan Fenhammar et al.   PLoS One

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Lymphocyte apoptosis is resistant to erythropoietin in porcine endotoxemia

(2010) CHRISTOFFER SØLLING et al.   APMIS

Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury

(2010) Johan Mårtensson et al.   INTENSIVE CARE MEDICINE

Augmented Renal Clearance

(2009) Andrew A. Udy et al.   CLINICAL PHARMACOKINETICS

Temporal pattern and effect of sex on lipopolysaccharide-induced stress hormone and cytokine response in pigs

(2009) P.N. Williams et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population

(2009) Dinna N. Cruz et al.   INTENSIVE CARE MEDICINE

Comparison of plasma clearance of exogenous creatinine, exo-iohexol, and endo-iohexol over a range of glomerular filtration rates expected in cats

(2009) Ingrid M. van Hoek et al.   JOURNAL OF FELINE MEDICINE AND SURGERY

Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs

(2008) F. GASTHUYS et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Systemic Administration of Enamel Matrix Derivative to Lipopolysaccharide-Challenged Pigs: Effects on the Inflammatory Response

(2008) R. Yngvar Gundersen et al.   Surgical Infections