期刊
DIAGNOSTICS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics11040711
关键词
periodontitis; diagnostics; point-of-care systems; biomarkers; matrix metalloproteinase 8; preventive medicine; oral health
资金
- Helsinki and Uusimaa Hospital District (HUS), Finland [TYH2016251, TYH2017251, TYH2018229, TYH2019319, Y1014SL017, Y1014SL018, Y1014SULE1]
- Finnish Dental Association Apollonia, Finland
- Karolinska Institutet, Sweden
- Yrjo Jahnsson Foundation sr, Finland
- Paulo Foundation, Finland
- Emil Aaltonen Foundation sr, Finland
- Juhani Aho Foundation for Medical Research sr, Finland
- Orion Research Foundation sr, Finland
- Finnish Dental Society Apollonia, Finland
- Helsingin Seudun Hammaslaakarit r.y. (Dentists of Helsinki Region Association), Finland
This study proposed an efficient strategy based on biomarkers and questionnaires to help medical professionals identify undiagnosed periodontitis patients. The use of oral fluid biomarkers in conjunction with a questionnaire was found to have better diagnostic precision compared to a plain questionnaire.
The aim of this cross-sectional study is to propose an efficient strategy based on biomarkers adjunct with an interview/questionnaire covering risk factors for periodontitis for the identification of undiagnosed periodontitis by medical professionals. Active matrix metalloproteinase (aMMP)-8 levels in mouthrinse were analyzed by a point-of-care (PoC)/chairside lateral-flow immunotest, and salivary total MMP-8, total MMP-9 and calprotectin levels were analyzed by enzyme-linked immunosorbent assays (ELISAs) and active MMP-9 by gelatin zymography for 149 Greek patients. Patients underwent a full-mouth oral health examination for diagnosis according to the 2018 classification system of periodontal diseases. In addition, patient characteristics (risk factors: age, gender, education level, smoking and body mass index) were recorded. Receiver operating curve (ROC) analysis indicated better diagnostic precision to identify undiagnosed periodontitis for oral fluid biomarkers in adjunct with an interview/questionnaire compared with a plain questionnaire (i.e., risk factors): aMMP-8 AUC (95% confidence interval) = 0.834 (0.761-0.906), total MMP-8 = 0.800 (0.722-0.878), active MMP-9 = 0.787 (0.704-0.870), total MMP-9 = 0.773 (0.687-0.858) and calprotectin = 0.773 (0.687-0.858) vs. questionnaire = 0.764 (0.676-0.851). The findings of this study suggest that oral fluid biomarker analysis, such as a rapid aMMP-8 PoC immunotest, could be used as an adjunct to an interview/questionnaire to improve the precision of timely identification of asymptomatic, undiagnosed periodontitis patients by medical professionals. This strategy appears to be viable for referring patients to a dentist for diagnosis and treatment need assessment.
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