Article
Psychiatry
Vicent Llorca-Bofi, Miquel Bioque, Maria Font, Ignasi Gich, Maria Mur
Summary: This study investigated the relationship between C-reactive protein (CRP) and inflammatory ratios in acute schizophrenia (SCZ) inpatients. The results showed that neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) were positively correlated with CRP levels, while basophil-lymphocyte ratio (BLR) showed no correlation. These associations were independent of sex and type of episode. It suggests that inflammatory ratios can be used as complementary biomarkers to CRP in SCZ patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Immunology
Tracy Bhikram, Paul Sandor
Summary: The review found that NLR is elevated in certain adult psychiatric disorders like schizophrenia, major depressive disorder, and bipolar disorder, but the associations with symptom severity and clinical parameters are not entirely clear. Results in youth populations are similar to those in adults, indicating a need for further research to better understand the relationship between NLR and specific psychiatric disorders. Future work is required to determine the neuroinflammatory mechanisms underlying these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Hongni Tian, Xuetao Jiang, Guangyou Duan, Jie Chen, Qi Liu, Yamei Zhang, Shiqi Li, Xiaohang Bao, He Huang
Summary: This study aimed to explore the role and predictive effects of preoperative inflammation on the primary outcomes after valvular cardiac surgery. The results showed that there was a significant association between preoperative inflammation and adverse outcomes after heart valve surgery. CRP level >5 mg/L effectively predicted postoperative heart failure, and NLR >3.5 had a good predictive effect on all-cause mortality within 30 days after surgery.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychiatry
Erman Esnafoglu, Burak Subasi
Summary: Inflammatory mechanisms and vitamin D play important roles in the pathophysiology of Autism Spectrum Disorders (ASD). This study found that ASD patients had significantly higher levels of inflammatory markers and significantly lower levels of vitamin D. There was a negative correlation between vitamin D and inflammatory markers.
PSYCHIATRY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shintaro Ishida, Seiji Kondo, Shunsuke Funakoshi, Atsushi Satoh, Toshiki Maeda, Miki Kawazoe, Chikara Yoshimura, Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Kosuke Masutani, Hitoshi Nakashima, Hisatomi Arima
Summary: The study found an association between white blood cell count and future development of hypertension in the general Japanese population, with an increase in white blood cell count associated with a higher incidence of hypertension. This association remained significant even after adjusting for other risk factors.
Article
Cell Biology
Heitor O. Santos, Larissa S. Limirio, Aline S. dos Reis, Rafaela Nehme, Joao Pedro Floriano, Gederson K. Gomes, Gustavo D. Pimentel, Erick P. de Oliveira
Summary: This study investigated the association between neutrophil-lymphocyte ratio (NLR) and C-reactive protein (CRP) with strength, muscle mass, and functional capacity in kidney transplant patients (KTPs). The results showed that NLR and CRP levels were not associated with these muscle-related parameters in KTPs.
Article
Clinical Neurology
Jiahui Yin, Rongpeng Gong, Min Zhang, Lei Ding, Ting Shen, Yiyun Cai, Shen He, Daihui Peng
Summary: This study found that both sleep disturbance and depression are associated with inflammation, but the role of inflammation in the relationship between sleep disturbance and depression is still unclear. The participants with depression and/or sleep disturbance had higher levels of inflammatory markers compared to those without. Sleep disturbance was positively correlated with inflammatory markers and depressive symptoms even after considering various confounding factors. Inflammatory markers mediated a small portion of the association between sleep disturbance and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Letter
Medicine, General & Internal
Qiao Zhu, Qian Zhang, Chen Chen, Miao Liu, Yao He, Yali Zhao, Shihui Fu
Summary: This cohort study investigates the association between biomarkers of inflammation-related aging, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio, and long-term mortality in Chinese centenarians.
Article
Psychiatry
Qi Zheng, Jin Liu, YaJuan Ji, Yan Zhang, XinChao Chen, BangShan Liu
Summary: This study compared the levels of inflammatory indicators derived from blood routine tests between adolescents with and without non-suicidal self-injury (NSSI). The results showed that adolescents with NSSI had significantly higher MLR and PLR compared to those without NSSI. MLR and PLR were independently associated with NSSI. ROC curve analysis demonstrated that MLR and PLR can be used to differentiate NSSI from non-NSSI.
Article
Immunology
Yuna Koyama, Nobutoshi Nawa, Yui Yamaoka, Hisaaki Nishimura, Shiro Sonoda, Jin Kuramochi, Yasunari Miyazaki, Takeo Fujiwara
Summary: In the context of the COVID-19 pandemic, both social isolation and loneliness are associated with chronic inflammation, especially when individuals experience both social isolation and loneliness simultaneously.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Kohei Yasui, Dai Shida, Yuya Nakamura, Yuka Ahiko, Shunsuke Tsukamoto, Yukihide Kanemitsu
Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.
BRITISH JOURNAL OF CANCER
(2021)
Review
Clinical Neurology
Felix Javier Jimenez-Jimenez, Hortensia Alonso-Navarro, Elena Garcia-Martin, Jose A. G. Agundez
Summary: The role of inflammatory factors in the development of restless legs syndrome (RLS) is not well understood. This study conducted a systematic review and meta-analysis to investigate the association between serum/plasma levels of inflammatory markers and the risk of RLS. The results indicated a trend of higher levels of C reactive protein (CRP) and neutrophil-to-lymphocyte (NLR) ratio in RLS patients, although statistical significance disappeared after applying the random-effects model. Further studies are needed to confirm the potential role of inflammatory factors in RLS pathogenesis.
SLEEP MEDICINE REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Marina Sagud, Zoran Madzarac, Gordana Nedic Erjavec, Ivona Simunovic Filipcic, Filip Luka Mikulic, Dunja Rogic, Zoran Bradas, Maja Bajs Janovic, Nela Pivac
Summary: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII index) are commonly used to indicate inflammation. Their relationship with negative symptoms, including anhedonia, in patients with schizophrenia is not well understood. This study found that there were weak to moderate positive correlations between various negative symptoms and blood cell inflammatory ratios in male patients, and weaker correlations in female patients. However, social anhedonia showed a negative correlation with the SII index in females, suggesting a possible different mechanism. Further exploration is needed to understand the relationship between anhedonia and inflammatory markers.
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Immunology
Jining He, Chenxi Song, Rui Zhang, Sheng Yuan, Jianjun Li, Kefei Dou
Summary: This study found that discordantly elevated NLR levels were associated with a greater risk of adverse clinical events in patients with stable CAD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Psychology, Developmental
Eugene Merzon, Margaret D. Weiss, Samuele Cortese, Ann Rotem, Tzipporah Schneider, Stephanie G. Craig, Shlomo Vinker, Avivit Golan Cohen, Ilan Green, Shai Ashkenazi, Abraham Weizman, Iris Manor
Summary: Age, male sex, and BMI were significant risk factors for increased COVID-19 severity, while ADHD was associated with more severe symptoms and referral to hospitalization in COVID-19 infection.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Acoustics
R. Birnbaum, R. Barzilay, M. Brusilov, P. Acharya, G. Malinger, K. Krajden Haratz
Summary: This study aimed to provide a detailed description of the sonographic appearance and development of various fetal structures of the midbrain and hindbrain (MBHB) during the early second trimester. The study found that transvaginal neurosonography allows for a detailed assessment of MBHB in the early second trimester and provides reference data that may aid in the early detection of brain pathology involving MBHB.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Psychology, Clinical
Noa Vardi, Gil Zalsman, Nir Madjar, Abraham Weizman, Gal Shoval
Summary: The COVID-19 pandemic has had significant implications on the mental health of mothers and their infants, with maternal stress reactions impacting infant development. Recommendations for enhancing perinatal mental health are discussed based on current research, with suggestions for future studies.
CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Psychology, Developmental
Stirling T. Argabright, Elina Visoki, Tyler M. Moore, Dallas T. Ryan, Grace E. DiDomenico, Wanjiku F. M. Njoroge, Jerome H. Taylor, Sinan Guloksuz, Ruben C. Gur, Raquel E. Gur, Tami D. Benton, Ran Barzilay
Summary: Youth suicide rates have been increasing in the United States, especially among Black Americans. This study aimed to investigate the unique contribution of racial/ethnic discrimination to childhood suicidal ideation and attempts. The findings showed that racial/ethnic discrimination is disproportionately experienced by Black children and is associated with preadolescent suicidality, emphasizing the need to address discrimination in suicide prevention strategies.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Environmental Sciences
Danielle Hen-Shoval, Aron Weller, Abraham Weizman, Gal Shoval
Summary: Depression and anxiety disorders are common and growing mental health concerns in adolescents, with antidepressant medication use increasing accordingly. Cannabis use may affect the efficacy of antidepressants, particularly among adolescents, highlighting the need for further research in this area.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Developmental
Lauren K. White, Ran Barzilay, Tyler M. Moore, Monica E. Calkins, Jason D. Jones, Megan M. Himes, Jami F. Young, Ruben C. Gur, Raquel E. Gur
Summary: Childhood adversity exposes youth to multiple negative outcomes. This study examines how a combination of risk and resilience factors impact mental health outcomes in relation to socioeconomic status (SES) and traumatic stressful events (TSEs). The findings highlight the importance of social support as a unique predictor for psychosis spectrum diagnoses and global functioning, and emotional dysregulation as an important predictor for mood disorders. The study underscores the significance of understanding the impact of childhood adversity on maladaptive outcomes within a resilience framework.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Neurosciences
Kristin Murtha, Bart Larsen, Adam Pines, Linden Parkes, Tyler M. Moore, Azeez Adebimpe, Aaron Alexander-Bloch, Monica E. Calkins, Diego G. Davila, Martin A. Lindquist, Allyson P. Mackey, David R. Roalf, J. Cobb Scott, Daniel H. Wolf, Ruben C. Gur, Raquel E. Gur, Ran Barzilay, Theodore D. Satterthwaite
Summary: Socioeconomic status (SES) has an impact on cognitive performance, particularly working memory (WM). This study found that both neighborhood SES and parental education were associated with greater activation of the executive system related to WM. Additionally, distinct patterns of brain activity within the executive system were identified, which mediated the relationship between SES and task performance.
Article
Psychology, Clinical
Oscar W. H. Wong, Ran Barzilay, Angela M. W. Lam, Sandra Chan, Monica E. Calkins, Raquel E. Gur, Ruben C. Gur
Summary: Executive function is uniquely associated with the severity of comorbid psychopathology in individuals with autism spectrum disorder (ASD), and could be a potential target for interventions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Linda Ruan-Iu, Alannah Shelby Rivers, Ran Barzilay, Tyler M. Moore, Allen Tien, Guy Diamond
Summary: Suicide is a significant and preventable public health issue. This study found that the general factor of psychopathology (p factor) score can better identify and predict individuals at risk for suicide, providing assistance to clinicians in detecting suicidal thoughts and behaviors among adolescents.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Nutrition & Dietetics
Orit Uziel, Hadar Dickstein, Einat Beery, Yael Lewis, Ron Loewenthal, Eran Uziel, Zipi Shochat, Abraham Weizman, Daniel Stein
Summary: The length of telomeres in anorexia nervosa (AN) patients is shorter and does not recover after inpatient treatment. Patients with the restricting type of AN have longer telomeres compared to those with the binge/purge type. Age is the only factor associated with telomere shortening.
Article
Nutrition & Dietetics
Eugene Merzon, Eli Magen, Shai Ashkenazi, Abraham Weizman, Iris Manor, Beth Krone, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Stephen V. Faraone, Ariel Israel
Summary: This study found an association between G6PD deficiency and an increased risk of ADHD diagnosis. Individuals with G6PD deficiency were more likely to seek care from adult neurologists and psychiatrists. Moreover, they had a higher usage of stimulant medications.
Article
Education, Special
Hagit Nagar Shimoni, Yael Leitner, Roni Yoran-Hegesh, Ya'arit Bokek-Cohen, Shahar Gindi, Abraham Weizman
Summary: Clinical observations suggest that girls suspected to have ASD may have better performance in social and emotional tasks than boys, leading to under-diagnosis of girls with ASD. The study found that girls diagnosed with ASD performed better than boys in the Person index of the Social Attribution Task (SAT), indicating that girls with ASD may not have better social understanding than boys, except when prompted to name human traits.
INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION
(2023)
Article
Genetics & Heredity
Laura M. Schultz, Alison K. Merikangas, Kosha Ruparel, Sebastien Jacquemont, David C. Glahn, Raquel E. Gur, Ran Barzilay, Laura Almasy
Summary: This study investigated the stability of polygenic scores (PGS) in individuals of European American and African American ancestry. The results showed that GWAS results from the same ancestry had high genetic correlations, while PGS calculated from different ancestry GWAS had lower correlations. Furthermore, the stability of PGS was higher for height compared to PTSD or T2D. The study also found that the correlation between PGS was dependent on the sample overlap between discovery GWAS.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
Article
Psychiatry
Maya Schwartz-Lifshitz, David H. Ben-Dor, Yael Bustan, Gil Zalsman, Doron Gothelf, Abraham Weizman, Ran Barzilay
Summary: This retrospective study analyzed the clinical and demographic characteristics of adolescents admitted to an acute psychiatric inpatient unit. The findings showed that adolescents with deliberate self-harm (DSH) were more likely to be female, currently experiencing depressive exacerbation, have concurrent suicidal ideation, and a history of alcohol use. There were no significant clinical differences between adolescents admitted following a suicide attempt and those engaging in non-suicidal self-injury.
ARCHIVES OF SUICIDE RESEARCH
(2022)
