Article
Biochemistry & Molecular Biology
Mami Oba, Wen Rongduo, Akatsuki Saito, Tamaki Okabayashi, Tomoko Yokota, Junko Yasuoka, Yoko Sato, Koji Nishifuji, Hitoshi Wake, Yutaka Nibu, Tetsuya Mizutani
Summary: The study demonstrated that a protease present in natto extract inhibits SARS-CoV-2 and BHV-1 infection by degrading viral proteins. However, heat treatment of the natto extract reverses this inhibitory effect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Samurailatpam Sanjukta, Srichandan Padhi, Puja Sarkar, Sudhir P. Singh, Dinabandhu Sahoo, Amit Kumar Rai
Summary: Kinema, a traditionally fermented soybean product popular in the Sikkim Himalayan region, demonstrated enhanced antioxidant effects through fermentation with different starters and further increased during gastrointestinal digestion. Peptides formed during fermentation may affect the functional properties of Kinema, with unique peptides potentially responsible for specific health benefits when prepared using specific starters. Interaction analysis showed a peptide produced in Kinema fermented with Bacillus licheniformis 1G to interact with catalytic residues in myeloperoxidase, suggesting potential benefits in reducing oxidative stress.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Applied
Reena Kumari, Nitish Sharma, Sangita Sharma, Sanjukta Samurailatpam, Srichandan Padhi, Sudhir P. Singh, Amit Kumar Rai
Summary: The study aimed to improve the functional properties of soybean meal (SBM) by using proteolytic Bacillus strains isolated from kinema, a fermented soybean product in Sikkim Himalaya. Different Bacillus species were employed for solid state fermentation (SSF) of SBM samples, and the water and methanol extracts of SBM hydrolysates showed increased antioxidant activity. Proteomic analysis of fermented soybean meal identified common and unique peptides produced by different starter cultures, and specific strains, such as B. subtilis KN36D, showed the highest diversity of peptides produced during fermentation. These results highlight the importance of selecting specific strains for fermentation to enhance the nutritional value of raw fermented biomass.
Review
Food Science & Technology
Danfeng Li, Lizhen Hou, Miao Hu, Yaxin Gao, Zhiliang Tian, Bei Fan, Shuying Li, Fengzhong Wang
Summary: This article discusses the role of nattokinase (NK) in cardiovascular diseases and its production methods. NK, as the most bioactive ingredient in natto, has potential beneficial cardiovascular effects. Microbial synthesis is an economical method for NK production, but yield, activity and stability remain limitations. These issues can be addressed through various optimization strategies.
Article
Biochemistry & Molecular Biology
Ga-Ram Yu, Dong-Woo Lim, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Gi-Young Kim, Hyuck Kim, Jai-Eun Kim, Won-Hwan Park
Summary: The study suggests that saponarin in Saponaria officinalis extract can reduce downstream inflammatory response by disrupting TLR4/MD2 complex and blocking MyD88-dependent inflammatory signaling.
Article
Biotechnology & Applied Microbiology
Joanna Ivy Irorita Fugaban, Jorge Enrique Vazquez Bucheli, Wilhelm Heinrich Holzapfel, Svetoslav Dimitrov Todorov
Summary: Bacillus velezensis, Bacillus amyloliquefaciens, and Bacillus subtilis strains isolated from artisanal-produced kimchi showed antimicrobial activity against Listeria monocytogenes, with some strains possibly having additional non-proteinaceous molecular structure related antimicrobial activity. These strains also expressed surfactin as an additional factor in their complex antimicrobial activity. Additionally, the studied Bacillus strains were resistant to some evaluated antibiotics and were positive producers for biogenic amines production.
FERMENTATION-BASEL
(2021)
Article
Multidisciplinary Sciences
Katherine U. U. Gaynor, Marina Vaysburd, Maximilian A. J. Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul Brear, Aleksei Lulla, Katarzyna Ciazynska, Veronica T. T. Chang, Jo Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G. G. Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P. P. Stewart, Andrew Owen, John A. G. Briggs, Marko Hyvonen, Michael J. J. Skynner, Leo C. C. James
Summary: The study presents the development of bicyclic peptides that combine the advantages of neutralizing antibodies and small molecule inhibitors, showing their antiviral capacity against SARS-CoV-2. This introduces a potential new antiviral modality to tackle new and rapidly evolving viruses.
NATURE COMMUNICATIONS
(2023)
Article
Fisheries
Mawalle Kankanamge Hasitha Madhawa Dias, E. H. T. Thulshan Jayathilaka, Shan Lakmal Edirisinghe, Jae-Woong Lim, Chamilani Nikapitiya, So Young Kang, Ilson Whang, Mahanama De Zoysa
Summary: In this study, octominin, an antimicrobial peptide derived from Octopus minor, was preliminarily tested for its antiviral activity and immune response in fish cells. The results suggest that octominin has potential as an antiviral agent, but further research is needed to understand its mechanism of action.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Food Science & Technology
Zhenjun Zhao, Yougen Lou, Yucheng Shui, Jian Zhang, Xianchun Hu, Lingling Zhang, Mengqiao Li, Huawei Wu, Xinghui Li
Summary: The study identified the diversity of ochratoxigenic fungi in post-fermented tea and revealed the inhibitory effect of Bacillus strains on these fungi. Results showed varying abilities of different strains to produce OTA, with Bacillus strains inhibiting both the growth and toxin production of the fungi. Co-cultivation of Bacillus and ochratoxigenic fungi on tea matrix significantly affected the growth of fungi producing OTA, with inhibitory effects influenced by factors such as inoculation order and fungal species differences.
Review
Plant Sciences
Shaoping Jiang, Xiaodan Wang, Maosong Yu, Jiaxue Tian, Ping Chang, Shijie Zhu
Summary: Fermented soybean foods are popular globally due to their rich nutrition, but many traditional fermented soybean foods have unacceptable bitterness caused by bitter peptides derived from soybean protein hydrolysis. This review briefly discusses the bitter peptides in fermented soybean foods, including their structural properties, influencing factors, and the relationship between peptide structure and bitterness. Understanding and studying bitter peptides in fermented soybean foods can improve their sensory quality and increase consumer acceptance.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Review
Food Science & Technology
Thangjam Anand Singh, Grihalakshmi Nongthombam, Gulden Goksen, Harikesh B. Singh, Gaurav Rajauria, Prakash Kumar Sarangi
Summary: Hawaijar, an ethnic vegan fermented soybean food from Manipur, India, is culturally and gastronomically significant. It shares similar characteristics with fermented soybean foods from Southeast Asia and has numerous health benefits due to the presence of functional microorganisms. However, unregulated production and sale have led to food safety issues, including the detection of potentially harmful pathogens. Improved and regulated food production can ensure hygienic and safe Hawaijar, which has the potential to enter the global market as a functional food and nutraceutical product, and contribute to the socioeconomic development of the region. This paper provides a summary of the scientific production methods of fermented soybean, discusses food safety issues, and highlights the health benefits and nutritional value of Hawaijar.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Gee Hyeun Choi, Joanna Ivy Irorita Fugaban, Clarizza May Dioso, Jorge Enrique Vazquez Bucheli, Wilhelm Heinrich Holzapfel, Svetoslav Dimitrov Todorov
Summary: Two Bacillus strains isolated from kimchi, Bacillus tequilensis ST816CD and Bacillus subtilis ST830CD, showed antimicrobial properties and were found to produce non-proteinaceous antimicrobial substances. These strains also expressed genes associated with the production of surfactants.
FERMENTATION-BASEL
(2021)
Article
Food Science & Technology
Yahui Song, Jia Yu, Jiale Song, Shanglong Wang, Tingfeng Cao, Zimin Liu, Xiang Gao, Yuxi Wei
Summary: The study demonstrated that RBPs have significant antihypertensive effects in spontaneously hypertensive rats, as well as the ability to improve heart, kidney, and vascular damage, regulate related signaling pathways, and enhance gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Hong Liu, Shen Luo, Jun Liu, Qiaojuan Yan, Shaoqing Yang, Zhengqiang Jiang
Summary: Green soybean shuidouchi, fermented by Bacillus velezensis, showed multiple bioactivities including anticoagulant, fibrinolytic, and antioxidant activities with optimized processing conditions. It contained higher levels of chemical components compared to unfermented shuidouchi, indicating its potential for further development of functional soybean products.
FOOD SCIENCE & NUTRITION
(2021)
Article
Food Science & Technology
Samurailatpam Sanjukta, Dinabandhu Sahoo, Amit Kumar Rai
Summary: The study demonstrated that fermented black soybean by different Bacillus spp. had enhanced antioxidant activity, with B. subtilis K2M showing the highest DPPH radical scavenging and reducing power activity during gastrointestinal digestion. This suggests the potential application of B. subtilis K2M for fermentation of black soybean for production of kinema and bioactive protein hydrolysates.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Green & Sustainable Science & Technology
Damilola Adeyeye, Adeyemi Olusola, Israel Ropo Orimoloye, Sudhir Kumar Singh, Samuel Adelabu
Summary: This study aims to assess the carbon footprint of the oldest university in Nigeria, the University of Ibadan, and highlights the need for greater attention in reducing emissions and transitioning to renewable energy. The study reports on the campus emissions related to direct and indirect sources, with the highest contribution coming from indirect emissions generated via purchased electricity.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Engineering, Electrical & Electronic
Sudhir Kumar Singh, Rajveer Singh, Haroon Ashfaq, Sanjeev Kumar Sharma
Summary: This paper proposes an Ant Colony Optimization (ACO) based Virtual Synchronous Machine (VSM) scheme to mitigate frequency disturbances in multimachine systems. The scheme offers flexible inertia and improved dynamic stability through optimal adjustment of emulated inertia.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Agronomy
Tsama Subrahmanyeswari, Saroj Laha, Suchita N. Kamble, Sudhir Singh, Somnath Bhattacharyya, Saikat Gantait
Summary: An accelerated, unique and efficient alginate-encapsulation-based mass propagation system was developed for stevia, which exhibited accelerated germination, higher shoot proliferation rate and elongation, and quicker root initiation and multiplication. Synthetic seed-regenerated plantlets showed clonal fidelity with their mother plant. This protocol is important for germplasm exchange and production of stevia.
Article
Water Resources
Gagan Matta, Avinash Kumar, Anjali Nayak, Pawan Kumar, Amit Kumar, Pradeep K. Naik, Sudhir Kumar Singh
Summary: This study assessed the potential risk of heavy metal pollution in water samples collected from 20 monitoring locations and the Ganga River System in the Himalayan region. The findings indicate that the Ganga River is impacted by untreated wastewater discharge from industrial, commercial, and residential complexes, resulting in heavy metal pollution.
INTERNATIONAL JOURNAL OF RIVER BASIN MANAGEMENT
(2023)
Article
Pediatrics
Jiledar Rawat, Sudhir Singh, Anand Pandey, Sarita Singh
Summary: The study aims to investigate the diagnosis and treatment options for anterior urethral valves (AUVs). The findings show that AUVs are rare congenital anomalies causing lower urinary tract obstruction in children, characterized by straining at micturition and a palpable penile swelling. Diagnosis can be confirmed through voiding cystourethrogram and cystoscopy. Surgical excision is the preferred method of treatment with excellent outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Environmental Sciences
Arbaaz Aziz Shaikh, Azazkhan Ibrahimkhan Pathan, Sahita Ibopishak Waikhom, Prasit Girish Agnihotri, Md Nazrul Islam, Sudhir Kumar Singh
Summary: Hydrodynamic models are essential in flood management as they help identify flood risk zones. This study used a GIS-integrated 2D hydrodynamic model to evaluate the 2006 flood event and determine the areas of inundation in Surat city. The model accurately simulated the flood and provided valuable information on flood depth, flow velocity, arrival time, and water surface elevation. The findings can assist decision-makers in making timely decisions to minimize casualties and property damage. Additionally, the study can contribute to reducing flood risks in vulnerable areas through effective flood control measures.
MODELING EARTH SYSTEMS AND ENVIRONMENT
(2023)
Article
Genetics & Heredity
Rajendra Kumar Imrat, Rajendra Kumar Labala, Abhisek Kumar Behara, Kumaraswamy Jeyaram
Summary: This study compared the intracellular and extracellular dsRNA of Tetragenococcus halophilus and found compositional and functional differences between them. The extracellular dsRNA had more unique sequences, potentially containing mobile regulatory elements. Furthermore, the extracellular dsRNA showed enrichment in cancer pathways and transcription process, indicating functional differences. Studying bacterial extracellular dsRNA is a promising area for future research, especially in developing functional fermented foods and understanding the impact of probiotics on human health.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Chemistry, Physical
Srichandan Padhi, Marco Masi, Yugal Kishore Mohanta, Muthupandian Saravanan, Swati Sharma, Alessio Cimmino, Dhivya Shanmugarajan, Antonio Evidente, Kumananda Tayung, Amit Kumar Rai
Summary: Seventy-three anticancer metabolites from different endolichenic fungi previously reported were analyzed for drug likeliness and pharmacokinetic properties. Three compounds, including talaromycin A, pyridoxatin, and terricollene A, showed strong binding affinity and stability, potentially serving as glycolytic inhibitors. These findings contribute to the development of potential glycolytic inhibitors for treating and controlling various forms of cancer, but further experimental investigations are needed to evaluate the efficacy of these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Geosciences, Multidisciplinary
Vishal Kumar Singh, H. K. Pandey, Sudhir Kumar Singh
Summary: This study estimates the variation in groundwater storage in the Ghaghara River basin using satellite observations, and finds a drastic decline in groundwater storage. The findings highlight the need for suitable water conservation schemes to improve water resource management in the entire basin.
PHYSICS AND CHEMISTRY OF THE EARTH
(2023)
Article
Geosciences, Multidisciplinary
Nirmal Kumar, Sudhir Kumar Singh, Pushpendra K. Singh, Dilip Kumar Gautam, Pooja Patle, H. K. Pandey, Pankaj Chauhan
Summary: This study used satellite observations and precipitation data from India Meteorological Department to estimate the total water consumption in a watershed. The results showed that CHIRPS precipitation data was more accurate compared to the observed data, indicating its suitability for studying hydrological processes in the central Himalayan river basin.
PHYSICS AND CHEMISTRY OF THE EARTH
(2023)
Article
Biochemistry & Molecular Biology
Shurooq Ismail, Rosa Gaglione, Marco Masi, Srichandan Padhi, Amit K. Rai, Ghadeer Omar, Alessio Cimmino, Angela Arciello
Summary: This study purified extracts from Ephedra foeminea and identified bioactive compounds with antimicrobial and antibiofilm properties. The compound kaempferol-3-O-alpha-L-(2 '',4 ''-di-E-p-coumaroyl)-rhamnopyranoside exhibited strong antibacterial and antibiofilm activity against S. aureus strains. Molecular docking studies suggested its potential applicability in biomedical and biotechnological fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Md Minhajul Abedin, Rounak Chourasia, Loreni Chiring Phukon, Puja Sarkar, Ramesh C. Ray, Sudhir P. Singh, Amit Kumar Rai
Summary: With its probiotic properties and capability to produce various biologically active metabolites, lactic acid bacteria (LAB) plays a significant role in the functional food industry. LAB can produce compounds that enhance nutraceutical properties, such as GABA, EPSs, CLA, bacteriocins, reuterin, and reutericyclin. They also produce specific enzymes essential for the production of bioactive compounds with numerous health benefits. Metabolically engineered LAB are widely used for enhancing the nutrition of food products, and the application of CRISPR-Cas9 holds great potential for food culture engineering.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Environmental Sciences
Ahmed Elbeltagi, Chaitanya B. B. Pande, Manish Kumar, Abebe Debele Tolche, Sudhir Kumar Singh, Akshay Kumar, Dinesh Kumar Vishwakarma
Summary: This study aims to predict meteorological drought events in the central India of Maharashtra state using machine learning algorithms. Random forest, random tree, and Gaussian process regression models were tested, and the results showed that the random forest model performed the best in forecasting drought events.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pediatrics
Rahul Kumar Rai, Anand Pandey, Shashwat Verma, Nitin Pant, Sudhir Singh, Nirpex Tyagi, Piyush Kumar, Jiledar Rawat
Summary: This study aimed to assess the management strategy for non-functional kidney (NFK), and found that in NFK caused by pelviureteric junction obstruction (PUJO), expectant treatment with percutaneous nephrostomy (PCN) followed by dismembered pyeloplasty is the primary treatment modality, and nephrectomy may not be needed.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Alexander Protasov, Olha Tomchenko, Tatiana Novoselova, Sophia Barinova, Sudhir Kumar Singh, Yulia Gromova, Angela Curtean-Banaduc
Summary: The impact of temperature on hydrobionts and pelagic communities in two reservoirs in southern Ukraine is studied. The cooling reservoir for the nuclear power plant shows no increase in temperature, while the other reservoirs experience a gradual temperature rise in summer.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)