Review
Materials Science, Biomaterials
Bingjie Hu, Guochen Bao, Xiaoxue Xu, Kai Yang
Summary: This review presents the importance and application of hemostatic materials in the context of coagulopathy, as well as the design principles and mechanisms of different materials. These recent advances have achieved significant success in addressing bleeding caused by coagulopathy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Simin Jiao, Xi Zhang, Hang Cai, Siyu Wu, Xiaolan Ou, Guangda Han, Jie Zhao, Yan Li, Wenlai Guo, Tianzhou Liu, Wenrui Qu
Summary: Despite significant medical advances in the past decade, achieving rapid and effective hemostasis remains a challenge. Uncontrolled bleeding and wound infections continue to be a concern, increasing the risk of death. There has been a growing interest in organisms that have adhesive properties, and applying these properties to hemostatic materials shows promise. This paper reviews the biological behavior, bionics, and mechanisms related to hemostasis, as well as the benefits, challenges, and prospects of biomimetic hemostatic materials.
MATERIALS TODAY BIO
(2023)
Review
Emergency Medicine
Peiyu Yu, Wen Zhong
Summary: Blood is essential in the human body, and hemostatic materials play a crucial role in saving lives in emergency situations. While commonly used hemostatic materials may have limitations, the design and development of high-performance hemostatic materials can enhance hemostatic efficiency.
Article
Chemistry, Multidisciplinary
L. Moumaneix, S. Fontana, F. Lapicque, C. Herold
Summary: Nitrogen-doped graphenic materials (N-Gr) are of great interest in electrocatalysis, and solvothermal-based processes are efficient for producing N-Gr with desirable properties. This article focuses on the influence of solvothermal reaction parameters, such as temperature, pressure, and sodium content, on the properties of N-Gr.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Bei-Er Jia, Ai Qin Thang, Chunshuang Yan, Chuntai Liu, Chade Lv, Qiang Zhu, Jianwei Xu, Jian Chen, Hongge Pan, Qingyu Yan
Summary: The high cost and scarcity of lithium resources have led researchers to seek alternatives, with rechargeable aluminum-ion batteries (AIBs) being an attractive option due to their high capacity and abundance of aluminum. Although nonaqueous AIBs have better electrochemical performance, aqueous AIBs have gained attention due to their low cost and enhanced safety. This review summarizes recent progress in developing stable electrodes and electrolytes for aqueous AIBs, as well as the challenges and future research outlook.
Article
Oncology
Vincenzo Dolcetti, Eleonora Lori, Daniele Fresilli, Giovanni Del Gaudio, Chiara Di Bella, Patrizia Pacini, Vito D'Andrea, Fabrizio Maria Frattaroli, Giulia Giordana Vallone, Piero Liberatore, Daniele Pironi, Gian Luigi Canu, Pietro Giorgio Calo, Vito Cantisani, Salvatore Sorrenti
Summary: To reduce bleeding-related morbidity in thyroid surgery, new techniques and devices for controlling bleeding have been introduced. The study aimed to describe the ultrasound appearance of topical hemostatics in patients undergoing thyroidectomy. The study evaluated the advantages and disadvantages of different hemostatic agents, including oxidized regenerated cellulose and fibrin glue.
Article
Chemistry, Multidisciplinary
Subin Jin, Sumin Kim, Dae Seok Kim, Donghee Son, Mikyung Shin
Summary: Bleeding control is crucial for survival in clinical and military settings. The development of an optically anisotropic topical hemostatic agent has the potential to provide a clear visual indication of bleeding, offering a new way to manage and prevent complications associated with internal hemorrhage.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bingxin Wu, Fanglin Du, A. Wenjing, Guofeng Li, Xing Wang
Summary: This article reviews the research progress of graphene-based sponges in the field of trauma hemostasis, focusing on their preparation strategies, hemostatic mechanisms, and future development prospects.
CHINESE CHEMICAL LETTERS
(2022)
Article
Nanoscience & Nanotechnology
E. Mohamed, A. Fitzgerald, T. Tsuzuki
Summary: Hemorrhage is a major cause of death in trauma, childbirth, and complex surgeries. Managing bleeding with topical hemostatic agents in the first hour after injury is crucial. Nanomaterials have enabled enhancements in current hemostatic materials and the development of new agents.
MATERIALS TODAY NANO
(2021)
Review
Biochemistry & Molecular Biology
A. P. Lunkov, A. A. Zubareva, V. P. Varlamov, A. M. Nechaeva, N. N. Drozd
Summary: Chitosan, a polysaccharide with unique biological properties, is commonly used as a basis for local hemostatic agents. Chemical modification of chitosan can enhance its hemostatic activity and ongoing research aims to identify promising approaches for obtaining effective hemostatic agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Wenli Han, Shige Wang
Summary: Currently, uncontrolled bleeding remains a serious problem in emergency, surgical and battlefield environments. In recent years, polymeric hydrogels with excellent hemostatic properties have received much attention because of their adjustable mechanical properties, high porosity, and biocompatibility. This review aims to investigate the role of hydrogels in hemostasis, by elucidating the mechanisms of hydrogel hemostasis and adhesion, introducing the adhesion design strategies of hemostatic hydrogels in wet environments, summarizing the studies and in vivo applications of wet-adhesive hemostatic hydrogels in different environments, and proposing the improvement directions of such hydrogels in future studies.
Review
Chemistry, Multidisciplinary
Zehong Yang, Lihong Chen, Ji Liu, Hua Zhuang, Wei Lin, Changlong Li, Xiaojun Zhao
Summary: Short designer self-assembling peptide (dSAP) biomaterials are innovative alternatives in hemostasis, providing safer and stronger hemostatic capacity in various surgical procedures. These biomaterials have proven to be effective in achieving immediate hemostasis, facilitating wound healing, and reducing the risks of post-operative bleeding and complications. The comprehensive evaluation of their biosafety, indications, quality, feasibility, and usability brings forth promising prospects for advancements in surgical techniques and peptide nanotechnology in clinics.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Daisuke Minakata, Urs von Gunten
Summary: Water quality and its impacts on human and ecosystem health pose significant global challenges. While oxidative water treatment can address many hygiene and micropollutant-related issues, predicting transformation products remains a major challenge. The combination of experimental and theoretical studies has advanced the understanding of reaction kinetics and mechanisms, but further research is needed to enhance predictive capability.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
A. Scarano, L. Leo, F. Lorusso, G. Tagariello, G. Falisi, C. Bugea, B. Rapone, A. Greco Lucchina, M. S. Di Carmine
Summary: Sufficient hemostasis is crucial in oral surgical procedures. This narrative review explores the management of bleeding in oral and dental practice through modern drugs. Acceptable hemostasis is important for visibility and a dry operational area. Topical hemostatic agents are commonly used by oral surgeons to promote platelet activation and clot formation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Optics
Linlin Shi, Keqiang Chen, Aiping Zhai, Guohui Li, Mingming Fan, Yuying Hao, Furong Zhu, Han Zhang, Yanxia Cui
Summary: This review focuses on metal-inorganic semiconductor-metal photodetectors (MSM-PDs) with semiconductor layers made of inorganic materials, including traditional semiconductors, wide bandgap semiconductors, and emerging semiconductors. It discusses the basic structures, working principles, research progresses, and optimization efforts of MSM-PDs, as well as concludes with the authors' perspectives on the future development of MSM-PDs.
LASER & PHOTONICS REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Han Zheng, Haifeng Li, Jingyuan Zhang, Hanlu Fan, Lina Jia, Wenqiang Ma, Shuoqian Ma, Shenghong Wang, Hua You, Zhinan Yin, Xiangdong Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Oncology
Huijiao Liu, Mei Liu, Hua You, Xiru Li, Xiangdong Li
FRONTIERS IN ONCOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Peng Li, Runjie Song, Fan Yin, Mei Liu, Huijiao Liu, Shuoqian Ma, Xiaomeng Jia, Xiaohui Lu, Yuting Zhong, Lei Yu, Xiru Li, Xiangdong Li
Summary: This study identifies circMRPS35 as a highly expressed circRNA in HCC and shows that its knockdown inhibits cell proliferation, migration, invasion, and colony formation, as well as tumor growth. circMRPS35 regulates PTEN expression and degradation through miR-148a and STX3. Additionally, the circMRPS35-encoded peptide circMRPS35-168aa promotes cisplatin resistance in HCC.
Article
Cell Biology
Kamila Pulawska, Donata Ponikwicka-Tyszko, Weronika Lebiedzinska, Peilan Guo, Piotr Bernaczyk, Agata Pilaszewicz-Puza, Xiangdong Li, Marcin Chrusciel, Oana Lupu, Sini Leskinen, Juho-Antti Makela, Jorma Toppari, Slawomir Wolczynski, Herjan J. T. Coelingh Bennink, Ilpo Huhtaniemi, Nafis A. Rahman
Summary: The study reveals unexpected ZP3 expression in the testis of healthy human and mouse, besides ovary, suggesting implications for the development of cancer immunotherapies and male immunocontraceptives targeting ZP3.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yongli Qin, Lina Jia, Huijiao Liu, Wenqiang Ma, Xinmin Ren, Haifeng Li, Yuanwu Liu, Haiwen Li, Shuoqian Ma, Mei Liu, Pingping Li, Jinghua Yan, Jiyan Zhang, Yangdong Guo, Hua You, Yan Guo, Nafis A. Rahman, Slawomir Wolczynski, Adam Kretowski, Dangsheng Li, Xiru Li, Fazheng Ren, Xiangdong Li
Summary: The research shows that NOC4L is reduced in humans and mice with obesity, and its deficiency worsens inflammation and insulin resistance induced by a high-fat diet. NOC4L interacts with Toll-like receptor 4 to inhibit endocytosis, thereby blocking TLF4/TRIF inflammatory signaling.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Runjie Song, Yaqi Du, Peng Li, Lijun Zhou, Han Zheng, Xiaohui Lu, Shenghong Wang, Wenqiang Ma, Hua Zhang, Xiangdong Li
Summary: This study found that LETMD1 plays a crucial role in the thermogenesis and energy homeostasis of brown adipose tissue. By regulating mitochondrial structures and functions, LETMD1 can affect mitochondrial fission and the concentration of Ca2+, thereby influencing the thermogenesis of brown adipose tissue.
Article
Biochemistry & Molecular Biology
Peng Li, Runjie Song, Yaqi Du, Huijiao Liu, Xiangdong Li
Summary: Brown and beige adipose tissues play a crucial role in maintaining body temperature and their impaired function can lead to metabolic diseases. This study identified a functional thermogenic regulator, Adtrp, which was significantly overexpressed in mature brown/beige adipocytes and played a key role in thermogenesis and metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medical Laboratory Technology
Shanshan Zhang, Yajing Liu, Mingming Wang, Donata Ponikwicka-Tyszko, Wenqiang Ma, Anna Krentowska, Irina Kowalska, Ilpo Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman, Xiangdong Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, but its etiology and targeted therapy options are still unknown. The reduced expression of miR-335-5p in PCOS patients suggests its potential as a diagnostic biomarker and therapeutic target for PCOS. Further studies revealed the mechanistic pathway of miR-335-5p in the etiopathogenesis of PCOS, making it a promising candidate for further research and development.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Jia, Huijiao Liu, Xinmin Ren, Peng Li, Runjie Song, Xiru Li, Yangdong Guo, Xiangdong Li
Summary: This study identified a novel SIRT1 regulatory protein, NOC4L, that binds to and inhibits the deacetylation of p53 mediated by SIRT1. Overexpression of NOC4L increases p53 acetylation and promotes cell apoptosis, while inhibiting tumor cell proliferation and tumor growth in a p53-dependent manner.
Article
Biochemistry & Molecular Biology
Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Slawomir Wolczynski, Guangming Li, Xiangdong Li
Summary: This study aims to elucidate the potential role and molecular mechanism of circZKSaa in the regulation of hepatocellular carcinoma (HCC) progression. Through a series of experiments, it was found that circZKSaa inhibited HCC progression and sensitized HCC cells to sorafenib. Furthermore, the high expression of cicZKSCAN1 in sorafenib-treated HCC cells was regulated by QKI-5. These findings demonstrate that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.
Article
Medical Laboratory Technology
Yajing Liu, Shanshan Zhang, Li Chen, Xuan Huang, Mingming Wang, Donata Ponikwicka-Tyszko, Nafis A. Rahman, Slawomir Wolczynski, Bing Yao, Xiangdong Li
Summary: The study found that miR-96-5p plays a crucial role in the pathogenesis of PCOS and may serve as a novel diagnostic biomarker and therapeutic target for PCOS.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A. Rahman, Slawomir Wolczynski, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu, Xiangdong Li
Summary: This study reanalyzed the circRNA expression data of TNBC and identified circCAPG as a potential biomarker in TNBC. Further experiments showed that circCAPG could encode a novel polypeptide, CAPG-171aa, which promoted the proliferation and metastasis of TNBC cells. Additionally, SLU7 was found to be involved in the formation of circCAPG. These findings provide new insights into the role of circCAPG in TNBC and its potential as a therapeutic target and prognostic biomarker.
Article
Medicine, Research & Experimental
Xiaohui Lu, Jingyuan Zhang, Huijiao Liu, Wenqiang Ma, Leo Yu, Xin Tan, Shubin Wang, Fazheng Ren, Xiru Li, Xiangdong Li
Summary: CBD has shown promising effects in reversing pathological changes, inhibiting proliferation of PASMCs, reducing inflammation and oxidative stress levels, and alleviating pulmonary arterial hypertension in rodent models by improving mitochondrial energy metabolism and reducing lactate accumulation.
Article
Oncology
Donata Ponikwicka-Tyszko, Marcin Chrusciel, Kamila Pulawska, Piotr Bernaczyk, Maria Sztachelska, Peilan Guo, Xiangdong Li, Jorma Toppari, Ilpo T. Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman
