Article
Clinical Neurology
Min Chen, Chao-Rong Xie, Yun-Zhou Shi, Tai-Chun Tang, Hui Zheng
Summary: This study using Mendelian randomization found that Actinobacteria, Bifidobacterium, and Ruminococcus have protective effects on major depressive disorders, while Streptococcaceae may have an anti-protective effect. Further research is needed to validate these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Pedro Borges de Souza, Laura de Araujo Borba, Louise Castro de Jesus, Ana Paula Valverde, Joana Gil-Mohapel, Ana Lucia S. Rodrigues
Summary: Major depressive disorder (MDD) is a significant contributor to the global burden of disease, with a complex interaction between environmental and genetic factors. Recent studies have shown that dysbiosis of the gut microbiota may contribute to the development of depression through dysregulation of the gut-brain axis. Physical exercise has been recognized as a potential therapeutic strategy for modulating the gut microbiota and alleviating MDD-related symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Igor Loniewski, Agata Misera, Karolina Skonieczna-Zydecka, Mariusz Kaczmarczyk, Karolina Kazmierczak-Siedlecka, Blazej Misiak, Wojciech Marlicz, Jerzy Samochowiec
Summary: One promising hypothesis regarding the pathogenesis of Major Depressive Disorder (MDD) is dysfunction in the gut-brain axis (GBA), particularly related to changes in the gut microbiota. This scoping review summarizes the current research on the relationship between MDD and gut microbiota. The findings suggest that alterations in the microbiota in MDD may be associated with various pathways related to inflammation, neurotransmitter production, and metabolic dysfunction. Further research is needed to clarify the mechanisms involved and to standardize research methods.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Immunology
Qi Zhong, Jian-jun Chen, Ying Wang, Wei-hua Shao, Chan-juan Zhou, Peng Xie
Summary: This study aimed to explore differential gut microbiota compositions related to the severity of major depressive disorder (MDD) and identified potential microbial markers for diagnosing MDD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Neurosciences
Peifen Zhang, Danhua Zhang, Jianbo Lai, Yaoyang Fu, Lingling Wu, Huimin Huang, Yanmeng Pan, Jiajun Jiang, Caixi Xi, Ziyuan Che, Xueqin Song, Shaohua Hu
Summary: This study aims to investigate the impact of gut microbial composition and function on metabolic dysfunction in bipolar disorder (BD) patients with an acute depressive episode. The results show that there are significant differences in gut microbial composition and diversity among normal weight, overweight/obesity, and healthy control groups. Specific bacterial taxa involved in lipid, energy, and amino acid metabolism may contribute to weight concerns in depressed BD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Shunjie Bai, Huili Bai, Detao Li, Qi Zhong, Jing Xie, Jian-jun Chen
Summary: This study identified potential biomarkers for objectively diagnosing major depressive disorder (MDD) and investigated the role of gut microbiota in depression onset. The results showed significant correlations between certain gut microbiota and inflammation-related factors with MDD severity. A panel of five inflammation-related factors effectively diagnosed MDD patients. These findings suggest the importance of Firmicutes and the potential of these factors as biomarkers for diagnosing MDD objectively.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Shunjie Bai, Jing Xie, Huili Bai, Tian Tian, Tao Zou, Jian-Jun Chen
Summary: By analyzing serum metabolomics and fecal microbial communities, this study identified potential biomarkers for MDD related to inflammation, which showed significant correlations with genera belonged to phyla Firmicutes and were able to effectively distinguish MDD patients from healthy controls.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Ping Lin, Dan Li, Yun Shi, Qingtian Li, Xiaokui Guo, Ke Dong, Qing Chen, Xiaoyan Lou, Zhenhua Li, Ping Li, Weifeng Jin, Shuzi Chen, Yang Sun, Jing Sun, Xunjia Cheng
Summary: Studies have shown that the gut microbiota is associated with neurological and psychiatric diseases. However, the changes in gut microbiota in patients with major depressive disorder (MDD) and their association with disease mechanisms are still unclear. This study recruited MDD patients and healthy controls, analyzed the compositional characteristics of the gut microbiota in MDD patients, and detected specific markers in their plasma. The results showed significant changes in the diversity and relative abundance of the gut microbiota in MDD patients, suggesting that these changes may potentially serve as biomarkers for MDD.
Article
Psychiatry
Xiaolin Ye, Dong Wang, Huaqian Zhu, Dahai Wang, Jing Li, Yanqing Tang, Jie Wu
Summary: The study found that there are differences in the composition of gut microbiota between MDD patients and healthy controls, and vortioxetine hydrobromide may treat MDD by regulating the gut microbiome.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Joseigla Pinto de Oliveira, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: The study aimed to assess the role of childhood trauma in differentiating MDD and BD, as well as to describe the conversion rate from MDD to BD and its predictors. Findings indicated that predictors of conversion to BD included lower education, substance abuse, younger age of onset, and family history, while childhood trauma was not a significant risk factor for conversion.
PSYCHIATRY RESEARCH
(2021)
Review
Behavioral Sciences
Julie Kristine Knudsen, Caspar Bundgaard-Nielsen, Simon Hjerrild, Rene Ernst Nielsen, Peter Leutscher, Suzette Sorensen
Summary: Gut microbiota in patients with MDD differs significantly from healthy controls, with variations in alpha and beta diversity, as well as specific changes in the relative abundance of certain bacteria. The heterogeneity in findings may be attributed to differences in study design and methodology.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: This study characterized the common and specific alterations in the dynamic local functional connectivity pattern in patients with bipolar depressive disorder (BDD) and major depressive disorder (MDD) using a newly developed method called dynamic regional phase synchrony (DRePS). The findings provided new insight into the neural mechanism of BDD and MDD patients and could potentially inform the diagnosis and treatment of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Jianbo Lai, Peifen Zhang, Jiajun Jiang, Tingting Mou, Yifan Li, Caixi Xi, Lingling Wu, Xingle Gao, Danhua Zhang, Yiqing Chen, Huimin Huang, Huijuan Li, Xin Cai, Ming Li, Peng Zheng, Shaohua Hu
Summary: The study found that the serum TRANK1 mRNA levels were elevated in depressed patients with bipolar disorder, and mice harboring the "BD microbiota" through FMT displayed depression-like behaviors, with increased levels of TRANK1 and inflammatory cytokines in the hippocampus and prefrontal cortex.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Junko Matsuo, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi, Miho Ota, Shinsuke Hidese, Yukihito Yomogida, Hiroshi Kunugi
Summary: This study found that patients with bipolar disorder (BD) have more severe cognitive impairments in depressed states compared to those with major depressive disorder (MDD), especially in perceptual organization, working memory, and processing speed. However, in euthymic states, cognitive impairments in both groups appear to be attenuated.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shinsuke Hidese, Kotaro Hattori, Daimei Sasayama, Takuya Tsumagari, Tomoko Miyakawa, Ryo Matsumura, Yuuki Yokota, Ikki Ishida, Junko Matsuo, Sumiko Yoshida, Miho Ota, Hiroshi Kunugi
Summary: Neural inflammation is believed to play a crucial role in psychiatric disorders. Through quantifying inflammatory cytokine levels in cerebrospinal fluid samples, this study aimed to identify the involvement of these cytokines in the pathophysiology of major psychiatric disorders. The findings suggest that interferon-beta may be a key player in the inflammation-related pathophysiology of these disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hitomi Matsuno, Shoko Tsuchimine, Kazunori O'Hashi, Kazuhisa Sakai, Kotaro Hattori, Shinsuke Hidese, Shingo Nakajima, Shuichi Chiba, Aya Yoshimura, Noriko Fukuzato, Mayumi Kando, Megumi Tatsumi, Shintaro Ogawa, Noritaka Ichinohe, Hiroshi Kunugi, Kazuhiro Sohya
Summary: Several lines of evidence suggest that stress-induced neurovascular dysfunction and increased blood-brain barrier permeability are important pathological links between stress and psychiatric disorders. This study demonstrates the crucial role of vascular endothelial growth factor in stress-induced blood-brain barrier dysfunction and depressive-like behavior development.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Yuuki Yokota, Kotaro Hattori, Yukihito Yomogida, Hiroshi Kunugi
Summary: This study examined the association between body mass index (BMI) and brain structure in individuals with a wide range of BMI. The results showed a negative correlation between BMI and cerebellum exterior volume, with lower volumes in the overweight or obese group compared to the underweight or normal group. There were also differences between sexes, with a significant correlation between BMI and cerebellum exterior volume only in women. These findings suggest that abnormal BMI may have an impact on regional gray matter volumes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Miho Ota, Kiyotaka Nemoto, Ikki Ishida, Shinji Sato, Takashi Asada, Tetsuaki Arai, Hiroshi Kunugi
Summary: This study evaluated the relationship between resilience and structural neural networks in individuals affected by a natural disaster. The results showed that the regional brain network in the right anterior cingulate cortex is associated with resilience in those exposed to a great natural disaster. This finding has potential clinical impact in understanding trauma- and stressor-related disorders.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Clinical Neurology
Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Yuuki Yokota, Kotaro Hattori, Yukihito Yomogida, Hiroshi Kunugi
Summary: This study investigates the association between sleep quality and brain structure in a non-psychiatric healthy population. The results suggest that poorer sleep quality is associated with impaired white matter integrity, but not with gray matter volume. This finding highlights the importance of maintaining good sleep quality for brain health in healthy adults.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Article
Neurosciences
Shinsuke Hidese, Fuyuko Yoshida, Ikki Ishida, Junko Matsuo, Kotaro Hattori, Hiroshi Kunugi
Summary: The aim of this study was to compare neuropeptide levels between patients with major psychiatric disorders and healthy controls, and examine their association with symptoms and cognitive function. The results showed that plasma neuropeptide levels were not significantly different between patients and healthy controls, and were not significantly correlated with symptoms or cognitive function.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Rheumatology
Yuya Fujita, Shigeru Iwata, Shinsuke Hidese, Sayuri Ishiwata, Satoru Ide, Hiroaki Tanaka, Koshiro Sonomoto, Yusuke Miyazaki, Shingo Nakayamada, Atsuko Ikenouchi, Kotaro Hattori, Hiroshi Kunugi, Reiji Yoshimura, Yoshiya Tanaka
Summary: The study aimed to find a new method of evaluation and surrogate markers for diffuse neuropsychiatric SLE (NPSLE). Retrospective evaluation revealed that many patients with active SLE have subclinical depression, and MADRS evaluation is useful in detecting them. Additionally, the decrease in CSF levels of HVA, SDF-1 alpha, and SCGF-1 beta reflects the same pathology, and these may serve as surrogate markers.
Editorial Material
Psychiatry
Shinsuke Hidese, Signe Duering, Rafael Penades
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Norie Koga, Yoko Komatsu, Ryo Shinozaki, Ikki Ishida, Yusuke Shimizu, Sonoko Ishimaru, Hiroshi Kunugi
Summary: This study examined the activity and heart rate variability (HRV) indices in depressive episodes of mood disorders using a wearable sensor. The results showed reduced activity and HRV indices in male depressed patients, suggesting a potential characteristic pathology of depression. The sympathetic load during sleep was found to be associated with a damped rest-activity rhythm in depressed patients.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
Article
Neurosciences
Ikki Ishida, Jun Ogura, Emiko Aizawa, Miho Ota, Shinsuke Hidese, Yukihito Yomogida, Junko Matsuo, Sumiko Yoshida, Hiroshi Kunugi
Summary: This study aimed to investigate gut permeability in schizophrenia patients and its relationship with symptoms, medication, cognitive functions, and blood immune markers. The results showed that gut permeability was significantly higher in schizophrenia patients compared to healthy controls, and it may be associated with cognitive and cellular immunity functions.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)