The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS

RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we highlight the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS. We also discuss different potential therapeutic strategies targeting these pathways.

Automated summary

RNA binding proteins play key roles in gene expression and their dysregulation has been implicated in the pathomechanisms of various neurodegenerative diseases, including ALS. Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. The review highlights the mechanistic interplay between RNA binding protein dysregulation, oxidative stress, and mitochondrial dysfunction in ALS, and discusses potential therapeutic strategies targeting these pathways.