Review
Physiology
Lucia Piacenza, Ari Zeida, Madia Trujillo, Rafael Radi
Summary: The free radical nitric oxide (NO) plays a key role in physiological processes, but its bioavailability is compromised in certain disease conditions due to increased production of superoxide radical. This leads to the inactivation of nitric oxide and the formation of peroxynitrite, which is implicated in various human diseases and the aging process. Understanding the complex biochemistry of peroxynitrite is crucial for developing therapeutic interventions.
PHYSIOLOGICAL REVIEWS
(2022)
Review
Engineering, Environmental
Yao Chen, Tongyao Zhao, Meiyu Bai, Tianrui Gu, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: Cancer is not a single disease, but a complex adaptive system involving inflammation, metabolism, and immunization. Combining multiple antineoplastic drugs offers advantages over monotherapy, but precise co-delivery into tumors remains challenging. Carrier-free nanoassemblies, engineered by small molecules, have emerged as a promising platform for co-delivery of anticancer drugs. This article provides an overview of the latest developments in this field, summarizing trends in nanomedicines, analyzing assembly mechanisms and drug release characteristics, and highlighting the prospects and challenges in clinical translation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Jennifer H. Pham, Gretchen A. Johnson, Rajiv S. Rangan, Charles E. Amankwa, Suchismita Acharya, Dorota L. Stankowska
Summary: This study evaluated the mechanisms underlying the neuroprotective effects of the compound SA-2 in retinal ganglion cell degeneration models. The results showed that SA-2 reduced apoptosis and decreased reactive oxygen species (ROS) levels in rat and human RGCs, suggesting that it may be a potential therapeutic strategy for preventing neurodegeneration in glaucomatous RGCs.
Review
Biochemistry & Molecular Biology
Charles E. Amankwa, Bindu Kodati, Nina Donkor, Suchismita Acharya
Summary: Reactive oxygen species play a significant role in ocular neurodegenerative diseases. The use of hybrid TEMPOL antioxidants shows potential in protecting the retina and optic nerve.
Article
Pharmacology & Pharmacy
Amina Rezkallah, Laurent Kodjikian, Aymeric Barbarroux, Corentin Laventure, Antoine Motreff, Samuel Chacun, Frederic Matonti, Philippe Denis, Thibaud Mathis
Summary: This study evaluated the intraocular pressure (IOP) response following dexamethasone implant (DEX-I) injection in eyes with a history of conventional filtering surgery or microinvasive glaucoma surgery (MIGS). It found that eyes with previous effective bleb therapy had better IOP control after DEX-I injections and mostly did not require additional IOP-lowering therapy or surgery.
Article
Ophthalmology
Tanuj Dada, Sudip Mondal, Neha Midha, Karthikeyan Mahalingam, Ramanjit Sihota, Shikha Gupta, Dewang Angmo, Raj Kumar Yadav
Summary: This study evaluated the effect of mindfulness-based stress reduction on intraocular pressure in patients with ocular hypertension. The results showed that mindfulness-based stress reduction led to a significant decrease in intraocular pressure and serum cortisol levels, along with improvements in optic nerve head perfusion and quality of life.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chen-rei Wan, Leroy Muya, Viral Kansara, Thomas A. Ciulla
Summary: Suprachoroidal drug delivery technology has rapidly advanced and shown promise in targeting a variety of ocular diseases. Customized drug formulations are critical in achieving favorable pharmacokinetics, and a range of therapeutic agents have demonstrated potential efficacy in animal studies. Ongoing research and optimization in suprachoroidal drug delivery may address unmet therapeutic needs in ophthalmology.
Article
Biochemistry & Molecular Biology
Paul Tawa, Lei Zhang, Essam Metwally, Yan Hou, Mark A. McCoy, W. Michael Seganish, Rumin Zhang, Emily Frank, Payal Sheth, Jennifer Hanisak, Christopher Sondey, David Bauman, Aileen Soriano
Summary: cGMP-dependent protein kinase (PKG) is an important drug target for cardiovascular diseases. In this study, a novel series of activators were identified that can directly bind and enhance the kinase activity of PKG1. These activators mimic the effect of cGMP on PKG1 by modulating its kinetic parameters and binding affinity for cGMP. They act by binding to an allosteric site near the regulatory domain of PKG1.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Computer Science, Artificial Intelligence
B. Keerthiveena, S. Esakkirajan, Badri Narayan Subudhi, T. Veerakumar
Summary: The study aims to devise and develop a computer-aided diagnosis system to assist ophthalmologists in early detection of glaucoma and diabetic retinopathy. The proposed technique involves pre-processing, feature selection, and classification, with performance assessed using eight different evaluation measures.
IET IMAGE PROCESSING
(2021)
Article
Materials Science, Biomaterials
Wan Huang, Jun Zhang, Li Luo, Yao Yu, Taolei Sun
Summary: As an important endogenous signaling molecule, nitric oxide (NO) is involved in various physiological and pathological activities in living organisms. It is proved that NO plays a critical role in tumor therapy, while its short half-life and nonspecific distribution limit its clinical applications. In recent years, progress has been made in developing innovative NO donors, especially smart and multi-modal nanoplatforms, that can precisely control the distribution of therapeutic agents for effective tumor treatment. This review comprehensively discusses the current mechanisms, breakthroughs, and potential of NO-based tumor treatments.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Brittany R. Benlian, Pavel E. Z. Klier, Kayli N. Martinez, Marie K. Schwinn, Thomas A. Kirkland, Evan W. Miller
Summary: Q-BOLT is a small-molecule enzyme pair for optical voltage sensing that utilizes quenching of bioluminescence to visualize changes in membrane potential in live cells. It combines three distinct readouts - QRET, BRET, and the ratio between bioluminescence emission and BRET - to accurately report membrane potential oscillations in HEK 293T cells and hiPSCs, without the need for excitation light.
Article
Chemistry, Medicinal
Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay U. Zyk, Ekaterina A. Nimenko, Anton P. Ber, Stanislav A. Petrov, Vladimir Polshakov, Radik R. Shafikov, Dmitry A. Skvortsov, Ekaterina A. Plotnikova, Andrei A. Pankratov, Galina B. Smirnova, Yulia A. Borisova, Vadim S. Pokrovsky, Vasilii S. Kolmogorov, Alexander N. Vaneev, Alexander D. Khudyakov, Olga E. Chepikova, Sergey Kovalev, Andrey A. Zamyatnin, Alexander Erofeev, Petr Gorelkin, Elena K. Beloglazkina, Nikolay Zyk, Elena S. Khazanova, Alexander G. Majouga
Summary: The synthesized PSMA-targeted conjugate shows promising potential for prostate cancer chemotherapy, with high tumor growth inhibition levels and therapeutic index on PSMA(+) xenografts compared to PSMA(-) xenografts. Acute, chronic, and subchronic toxicities studies, as well as pharmacokinetics, support the potential of this conjugate as a therapeutic agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Minh-Duc Hoang, Jean-Baptiste Bodin, Farah Savina, Vincent Steinmetz, Jerome Bignon, Philippe Durand, Gilles Clavier, Rachel Meallet-Renault, Arnaud Chevalier
Summary: CinNapht is a donor-acceptor system formed by fusing a six-membered-diaza ring of cinnoline with naphthalimide dye, exhibiting red shifted fluorophore, large Stoke shift, high fluorescence quantum yield up to 0.33, strong solvatochromic effect, and potential for bio-imaging applications.
Article
Agricultural Engineering
Yi Sun, Huiwen Pang, Zhi Li, Haijiao Kang, Hongguang Liu, Songwu Chen
Summary: This study explored the effects of incorporating curcumin into SPI-based nanocomposite films on the antimicrobial properties of the films. The modified drug-carrier system successfully loaded curcumin onto cellulose nanofibril, resulting in films with satisfactory antibacterial and mechanical properties.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Microbiology
Elena K. Gaidamakova, Ajay Sharma, Vera Y. Matrosova, Olga Grichenko, Robert P. Volpe, Rok Tkavc, Isabel H. Conze, Polina Klimenkova, Irina Balygina, William H. Horne, Cene Gostincar, Xiao Chen, Kira S. Makarova, Igor Shuryak, Chandra Srinivasan, Belinda Jackson-Thompson, Brian M. Hoffman, Michael J. Daly
Summary: The oxidative damage theory by Denham Harman suggests that superoxide radicals play a central role in aging and radiation injury, with Mn2+-dependent superoxide dismutase (MnSOD) being the main scavenger. However, research on radiation-resistant organisms like Caenorhabditis elegans and Deinococcus radiodurans shows that MnSOD may not be essential for longevity or radiation resistance. Instead, these organisms accumulate small-molecule Mn2+-antioxidant complexes which could be the primary defense against reactive oxygen species, potentially complementing or even replacing MnSOD.
Article
Chemistry, Multidisciplinary
Roshni Iyer, Tam Nguyen, Dona Padanilam, Cancan Xu, Debabrata Saha, Kytai T. Nguyen, Yi Hong
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biotechnology & Applied Microbiology
Serkan Yaman, Harish Ramachandramoorthy, Gizem Oter, Daria Zhukova, Tam Nguyen, Manoj K. Sabnani, Jon A. Weidanz, Kytai T. Nguyen
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Louis Hinkle, Duong Le, Tam Nguyen, T. Vy, Charles E. Amankwa, Courtney Weston, Haifa Shen, Kytai T. Nguyen, Maham Rahimi, Suchismita Acharya
Summary: The hybrid molecule SA-10 with dual functions of NO donation and ROS scavenging showed potent cytoprotective effects and tube formation activity in endothelial cells under oxidative stress. SA-10 NPs delivered intramuscularly to murine ischemia models significantly reduced muscle damage and inflammation in acute ischemia/reperfusion, while improving blood perfusion and physical endurance in chronic ischemia model over 30 days. This potential therapeutic alternative to surgery may benefit elderly patients with limited options for interventions.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Orthopedics
Cynthia M. Co, Tam Nguyen, Bhavya Vaish, Samira Izuagbe, Joseph Borrelli Jr, Liping Tang
Summary: This study evaluated the use of PDGF-releasing adhesives to improve the healing of glenoid labral tears by promoting progenitor cell recruitment and increasing extracellular matrix production. The results showed that PDGF-releasing adhesives significantly enhanced progenitor cell recruitment and labral healing.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Cell Biology
Jennifer H. Pham, Gretchen A. Johnson, Rajiv S. Rangan, Charles E. Amankwa, Suchismita Acharya, Dorota L. Stankowska
Summary: This study evaluated the mechanisms underlying the neuroprotective effects of the compound SA-2 in retinal ganglion cell degeneration models. The results showed that SA-2 reduced apoptosis and decreased reactive oxygen species (ROS) levels in rat and human RGCs, suggesting that it may be a potential therapeutic strategy for preventing neurodegeneration in glaucomatous RGCs.
Article
Biochemistry & Molecular Biology
Dorota L. Stankowska, J. Cameron Millar, Bindu Kodati, Sumita Behera, Renuka M. Chaphalkar, Tam Nguyen, Kytai T. Nguyen, Raghu R. Krishnamoorthy, Dorette Z. Ellis, Suchismita Acharya
Summary: The new compound SA-2 has been shown to upregulate cGMP in TM cells, increase outflow facility, and decrease IOP in rodent models. It provides cytoprotective activity by scavenging ROS and enhancing SOD enzyme activity. The PLGA nanosuspension formulation (SA-2 NPs) offers a longer duration of IOP-lowering activity compared to the free drug.
Article
Materials Science, Biomaterials
Min Kyung Khang, Aneetta Elizabeth Kuriakose, Tam Nguyen, Cynthia My-Dung Co, Jun Zhou, Thuy Thi Dang Truong, Kytai Truong Nguyen, Liping Tang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Ophthalmology
Dorota L. Stankowska, Adnan Dibas, Linya Li, Wei Zhang, Vignesh R. Krishnamoorthy, Sai H. Chavala, Tam Pho Nguyen, Thomas Yorio, Dorette Z. Ellis, Suchismita Acharya
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)