Review
Polymer Science
Laura Ricciotti, Antonio Apicella, Valeria Perrotta, Raffaella Aversa
Summary: With advancements in bone tissue engineering, the development of innovative biomaterials is crucial for improving bone healing. This review thoroughly examines the current applications and future potential of geopolymers in bone tissue engineering. Traditional bioscaffold materials are also compared, analyzing their strengths and weaknesses. The concerns regarding the widespread use of alkali-activated materials as biomaterials and the potential of geopolymers as ceramic biomaterials are discussed.
Review
Biotechnology & Applied Microbiology
Long Chen, Chao Zhou, Chanyi Jiang, Xiaogang Huang, Zunyong Liu, Hengjian Zhang, Wenqing Liang, Jiayi Zhao
Summary: The objective of bioimplant engineering is to develop biologically compatible materials for restoring, preserving, or altering damaged tissues and/or organ functions. Nanomaterials can mimic the surface properties of normal tissues and have potential applications in orthopedic implant procedures. However, there are challenges and barriers that need to be addressed before nanomedicine can be widely applied in orthopedics. Evaluation: 8/10.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yanli Zhu, Zheng Wang, Longjian Bai, Jing Deng, Qihui Zhou
Summary: This review presents recent advances in biomaterial-based encapsulated probiotics, including methods, materials, and effects. Encapsulation within biomaterials enhances the stability and delivery efficiency of probiotics, with diverse biomedical applications.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Multidisciplinary
Hairui Gao, Jingzhou Yang, Xia Jin, Xinhua Qu, Faqiang Zhang, Dachen Zhang, Haishen Chen, Huiling Wei, Shupei Zhang, Weitao Jia, Bing Yue, Xiaopeng Li
Summary: Porous tantalum scaffolds are superior implantable biomaterials for orthopedic applications due to their exceptional properties and structure that mimic human bone tissues. Additive manufacturing has revolutionized the fabrication of patient-specific tantalum bone implants with well-designed architectures, making them new biomaterials for bone repair. Further research is essential to evaluate the safety and efficacy of these scaffolds for orthopedic applications, with biomechanical studies and porous structure design being additional hot topics in tantalum scaffold research.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Naoto Saito, Hisao Haniu, Kaoru Aoki, Naoyuki Nishimura, Takeshi Uemura
Summary: Numerous studies have been conducted on using nanocarbons as biomaterials in various applications, but their clinical use is hindered by safety concerns. Advances have been made in evaluating the biosafety of nanocarbons, including establishing optimal controls, refining nanocarbon dispersal techniques, increasing the array of biokinetic evaluation methods, and developing strict carcinogenicity examinations. This review focuses on carbon nanotubes and summarizes current contributions and achievements in evaluating nanocarbon applications and biosafety, as well as discussing future prospects and systematic introduction of carbon nanomaterials for clinical use.
Review
Metallurgy & Metallurgical Engineering
Fei Xing, Shang Li, Dongdi Yin, Jichang Xie, Zhou Xiang, Ming Liu, Ulrike Ritz
Summary: Traditional orthopedic metal implants like titanium and cobalt-chromium alloys cannot degrade in vivo, leading to bone loss. In contrast, biodegradable magnesium alloys, with characteristics such as low density and good biocompatibility, are gaining attention in orthopedic fixation.
JOURNAL OF MAGNESIUM AND ALLOYS
(2022)
Review
Chemistry, Physical
Sung-ryul Choi, Ji-won Kwon, Kyung-soo Suk, Hak-sun Kim, Seong-hwan Moon, Si-young Park, Byung Ho Lee
Summary: As surgical treatments in orthopedics expand, the development of biomaterials used for these treatments has advanced. Biomaterials have osteobiologic properties and can be classified as natural polymers, synthetic polymers, ceramics, allograft-based substitutes, and metallic implants. This review discusses the fundamental characteristics of metals and biomaterials used in the field, as well as advancements in nanotechnology and 3D-printing technology. A complementary relationship between doctors and biomaterial scientists is likely to be necessary in the future.
Article
Chemistry, Physical
Maria J. C. Vilela, Bruno J. A. Colaco, Jose Ventura, Fernando J. M. Monteiro, Christiane L. Salgado
Summary: Designing biomaterials for bone-substitute applications remains a challenge due to the complex structure of hard tissues. This study aimed to scale up the production of a porous biocomposite scaffold for bone regeneration applications using a prototype bioreactor, showing reproducible properties relative to bench development and potential for commercialization. In vitro and in vivo tests demonstrated the scaffolds' ability to promote cell proliferation, osteogenic differentiation, tissue ingrowth, and defect filling, as well as non-cytotoxicity. The optimized production process successfully harnessed knowledge from basic sciences to enhance human health.
Review
Orthopedics
Bennett Oakes, Ioanna K. Bolia, Alexander E. Weber, Frank A. Petrigliano
Summary: Research on the application of vitamin C in orthopaedics shows potential benefits in bone health, tendon healing, postoperative pain reduction, and prevention of complex regional pain syndrome. However, further high-quality human trials are needed to confirm its effectiveness and determine optimal dosage and administration methods.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xu Li, Bingyang Dai, Jiaxin Guo, Yuwei Zhu, Jiankun Xu, Shunxiang Xu, Zhi Yao, Liang Chang, Ye Li, Xuan He, Dick Ho Kiu Chow, Shian Zhang, Hao Yao, Wenxue Tong, To Ngai, Ling Qin
Summary: A magnesium-based artificial bandage was fabricated to activate periosteum-associated biomineralization and promote bone healing. The bandage released magnesium ions to activate endogenous periosteal macrophages into M2 phenotype, and also stimulated blood vessel formation and neurite outgrowth. As a result, the surrounding newly formed bone tissue covered the defected area.
Review
Materials Science, Biomaterials
Indra J. Budiarso, Novi D. W. Rini, Annisa Tsalsabila, Muhammad D. Birowosuto, Arie Wibowo
Summary: Over the past decade, smart and functional biomaterials have become one of the most rapidly emerging fields in life sciences due to their potential to improve biomaterial performance through their interaction and response with living systems. Chitosan, with its beneficial properties such as biodegradability, hemostatic and antibacterial activity, biocompatibility, and versatility, plays a crucial role in this field. This review provides an up-to-date development of various structures of chitosan-based smart biomaterials and highlights their applications in the biomedical field, specifically in drug delivery systems, bone scaffolds, wound healing, and dentistry.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Medicine, General & Internal
Valentin Herber, Begum Okutan, Georgios Antonoglou, Nicole G. Sommer, Michael Payer
Summary: Synthetic Mg-based biomaterials are promising candidates for bone regeneration due to their bone-like properties, different Mg-based alloys have been developed to fit clinical requirements, and advances in additive manufacturing offer the possibility to fabricate bioresorbable metallic porous scaffolds.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Engineering, Biomedical
Hongyu Quan, Chencan Ren, Yuwei He, Fuyou Wang, Shiwu Dong, Hong Jiang
Summary: Osteonecrosis of the femoral head (ONFH) is a progressive pathological process caused by multiple etiologies, with no complete cure at present. Biomaterials have gained extensive attention in the treatment of early ONFH, aiming to sustain normal morphology and function, and slow disease progression.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Sumel Ashique, Obaid Afzal, Mohammad Khalid, Md Faruque Ahmad, Aakash Upadhyay, Shubneesh Kumar, Ashish Garg, Mohhammad Ramzan, Afzal Hussain, Mohammad A. Altamimi, Abdulmalik S. A. Altamimi, Thomas J. Webster, Anjum Khanam
Summary: Nanotechnology has vast applications in various fields such as food science, biotechnology, and nanobiotechnology. With the increasing problem of non-biodegradable waste, new technologies are needed, and nanotechnology can transform biodegradable waste into useful products. Biogenic production of metallic nanoparticles (NPs) using fruit and vegetable waste has become a promising alternative to traditional synthesis methods due to its simplicity and eco-friendliness. This review discusses different sources of biogenic NPs, extraction processes, pharmacological functionality, industrial aspects, and future perspectives.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Vlad Al Georgeanu, Oana Gingu, Iulian V. Antoniac, Horia O. Manolea
Summary: The ideal biomaterials substitute for bone repair should possess various properties such as osteogenic, osteoinductive, and osteoconductive abilities, as well as promote the process of neo-angiogenesis. It should also have no antigenic, teratogenic, or carcinogenic reactions and avoid systemic toxicity complications. In addition, it should provide sufficient mechanical support and stability, have hydrophilic surface properties, good interface with human bone, be easily sterilized and supplied in large quantities at a low cost. Despite efforts, the perfect bone reconstruction material has not been developed, requiring further research. This article aims to provide an overview of grafting materials for bone defects treatment, discussing their properties, advantages, and disadvantages, and highlighting the present and future perspectives in bone graft and biomaterials research.
APPLIED SCIENCES-BASEL
(2023)
Article
Clinical Neurology
Ke-Xiao Yu, Lei Chu, Liang Chen, Lei Shi, Zhong-Liang Deng
CLINICAL SPINE SURGERY
(2019)
Article
Clinical Neurology
Ke-Xiao Yu, Lei Chu, Jun-Song Yang, Rui Deng, Liang Chen, Lei Shi, Ding-Jun Hao, Zhong-Liang Deng
WORLD NEUROSURGERY
(2019)
Article
Clinical Neurology
Jun-Song Yang, Lei Chu, Rui Deng, Chien-Min Chen, Xiang-Fu Wang, Pei-Gen Xie, Ke-Xiao Yu, Li-Min Rong, Ding-Jun Hao, Jian-Min Wei, Zhong-Liang Deng
WORLD NEUROSURGERY
(2019)
Article
Clinical Neurology
Lei Shi, Kai Shen, Lei Chu, Ke-Xiao Yu, Qing-Shuai Yu, Rui Deng, Zhong-Liang Deng
WORLD NEUROSURGERY
(2019)
Article
Materials Science, Biomaterials
Bing Liang, Deyu Zuo, Kexiao Yu, Xiaojun Cai, Bin Qiao, Rui Deng, Junsong Yang, Lei Chu, Zhongliang Deng, Yuanyi Zheng, Guoqing Zuo
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Biotechnology & Applied Microbiology
Ke-Xiao Yu, Wei-Zhong Lu, Chang-Ming Xiao, Lei Chu, Rui Deng, Liang Chen, Zhong-Liang Deng
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Hang Zhou, Kexiao Yu, Haitao Jiang, Rui Deng, Lei Chu, Youde Cao, Yuanyi Zheng, Weizhong Lu, Zhongliang Deng, Bing Liang
Summary: The study successfully synthesized injectable PMM hydrogels that can accelerate bone regeneration and form porous scaffolds, significantly promoting bone cell proliferation, differentiation, and deposition by controlling Mg2+ release. Micro-CT imaging and histological analysis demonstrated that PMM hydrogels effectively stimulated in situ bone regeneration in rat calvarial defects.
Article
Nanoscience & Nanotechnology
Bing Liang, Bin Qiao, Kexiao Yu, Jin Cao, Hang Zhou, Qinqin Jiang, Yixin Zhong, Youde Cao, Zhigang Wang, Yuanyi Zheng
Summary: An oxygen-irrelevant free radicals generation strategy has been developed for hypoxic tumor therapy. A hierarchical targeting system composed of Fe-doped polydiaminopyridine nanoshuttles, indocyanine green (ICG), and an oxygen-irrelevant radicals generator (AIPH) was constructed to enhance tumor accumulation and intracellular localization. The nanoshuttles demonstrated efficient tumor delivery and mitochondria targeting, resulting in a powerful tumor inhibition rate. The presence of iron and ICG enabled magnetic resonance imaging, photoacoustic imaging, and fluorescence imaging to guide the therapeutic process.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Bing Liang, Yijia Cao, Xinmei Wang, Hang Zhou, Mengna Wang, Youde Cao, Weizhong Lu, Kexiao Yu
Summary: Osteolytic lesions of bone tumors can be effectively treated using magnetic hyperthermia, but it is not satisfactory when used alone and may have systemic side effects when combined with chemotherapy. We developed a biomimetic bone magnet that can efficiently target chemotherapy substances to the tumor area, providing a new treatment strategy for malignant bone tumors.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Biomaterials
Bing Liang, Kexiao Yu, Yi Ling, Micheal Kolios, Agata Exner, Zhigang Wang, Bing Hu, Guoqing Zuo, Yu Chen, Yuanyi Zheng
BIOMATERIALS SCIENCE
(2019)
Article
Medicine, Research & Experimental
Kexiao Yu, Bing Liang, Yuanyi Zheng, Agata Exner, Michael Kolios, Tiantian Xu, Dajing Guo, Xiaojun Cai, Zhigang Wang, Haitao Ran, Lei Chu, Zhongliang Deng