期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.679558
关键词
hemicellulosic polysaccharide; incomplete degradation products of galactomannan; antioxidant function; immunomodulatory activity; Sesbania cannabina
资金
- National Key R&D Program of China [2016YFD0600803]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The study demonstrated that the incomplete degradation products of galactomannan (IDPG) can enhance antioxidant capacity and immunomodulatory activity, leading to potential improvements in overall health.
As known, the nutritional status affects antioxidant capacity and immunity, ultimately affecting the body's health. Recently, hemicellulosic polysaccharides of galactomannan in different biomass and their degradation products are gaining more attention due to excellent antioxidant enhancement and immunomodulatory activity. Herein, incomplete degradation products of galactomannan (IDPG) were prepared from the enzymatic hydrolysis of Sesbania cannabina seeds, followed by the in vitro and in vivo experiments. Using an H2O2-injured RAW264.7 cells model, IDPG was demonstrated to have antioxidant capacity, as indicated by superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. While in the evaluation in laying hens (68-weeks-old), diets were supplemented with 0, 0.01, 0.025, and 0.05% IDPG for 8 weeks, respectively. Our results showed that IDPG can improve antioxidant capacity by increasing antioxidants contents and reducing MDA content. Furthermore, IDPG can increase immunoglobulins and cytokines secretion, thereby enhancing the immunity of laying hens. This result was further demonstrated by in vitro experiment, in which IDPG significantly increased the secretion of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and toll-like receptor 4 (TLR4) in RAW264.7 cells (P < 0.05). Overall, IDPG can improve antioxidant function and modulate immunological response, thereby the concept of using IDPG for health may gain a little more credibility.
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