Review
Cell Biology
Sheng-yu Zhu, Ren-qi Yao, Yu-xuan Li, Peng-yue Zhao, Chao Ren, Xiao-hui Du, Yong-ming Yao
Summary: TFEB, a member of MiTF/TFE family, plays a critical role in maintaining structural integrity and functional balance of various cells. Activated TFEB enters the nucleus to induce target gene expressions, participating in organelle biosynthesis, lysosome-autophagy pathway, metabolism regulation, immune, and inflammatory responses. Dysregulation of TFEB is associated with the pathophysiological processes of various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Fengjuan Jiao, Bojie Zhou, Lingyan Meng
Summary: This review discusses the regulation and functions of transcription factor EB (TFEB) in the autophagy-lysosomal pathway (ALP), as well as its role in various neurodegenerative diseases. The protective effects and molecular mechanisms of TFEB-targeted agonists in neurodegeneration are summarized, and the pros and cons of these agonists in the treatment of neurodegenerative diseases are analyzed from the perspective of drug development. Further studies on the regulatory mechanisms of TFEB in other biological processes will enhance our understanding of the application of TFEB-targeted therapy in neurodegeneration.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Xiaoyan Zheng, Wenjia Lin, Yimin Jiang, Kejia Lu, Wenjing Wei, Qingwei Huo, Shaoyang Cui, Xifei Yang, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song
Summary: This study demonstrated the cognitive-enhancing effect of three-needle electroacupuncture in an animal model of Alzheimer's disease. The treatment reduced protein aggregation and inhibited glial cell activation by activating TFEB and promoting ALP in the brain. This suggests that three-needle electroacupuncture could be a promising therapy for Alzheimer's disease through a novel mechanism involving TFEB activation.
Article
Veterinary Sciences
Hao Yu, Xinxing Gao, Juan J. Loor, Qianming Jiang, Zhiyuan Fang, Xue Hao, Zhen Shi, Minghe Fan, Meng Chen, Xinwei Li, Guowen Liu, Zhe Wang, Xiaobing Li, Xiliang Du
Summary: Excessive lipid mobilization caused by severe negative energy balance is the pathological basis for subclinical ketosis in dairy cows. This study found that enhanced transcriptional activity of the TFEB may contribute to lipolysis of adipose tissue in cows with subclinical ketosis. Regulation of TFEB activity could be an effective therapeutic strategy for controlling overt lipolysis in ketotic cows.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Man Zhang, Yang Bai, Chang Xu, Yiying Qi, Jiahong Meng, Wenkan Zhang, Hang Su, Weiqi Yan
Summary: The study identified an ERK inhibitor (ERKi; Vx-11e) with potential antitumor activities, which regulates autophagy and mitochondrial apoptosis pathways, increasing the dependence of Osteosarcoma cells on autophagy. This suggests that ERKi could be a potential therapeutic agent for the treatment of Osteosarcoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
De Lai Xu, Jie Pan
Summary: The study revealed the crucial role of TFEB in regulating autophagy in the progression of rheumatoid arthritis, providing potential novel targets for the therapy of RA.
Article
Biochemistry & Molecular Biology
Zhensheng Zhang, Li Xu, Xun Qiu, Xinyu Yang, Zhengxing Lian, Xuyong Wei, Di Lu, Xiao Xu
Summary: Tacrolimus (TAC) is an immunosuppressant commonly used after liver transplantation, but it is associated with post-transplant hyperlipemia. The mechanism behind this is unclear, and there is a need to explore preventive strategies for hyperlipemia. In a mouse model, we found that TAC treatment led to hyperlipemia and lipid accumulation in the liver. TAC also inhibited the autophagy-lysosome pathway and downregulated fibroblast growth factor 21 (FGF21). Overexpression of FGF21 reversed TAC-induced lipid accumulation and hyperlipemia by enhancing autophagy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Cell Biology
Zhenzhen Chen, Chenxi Ouyang, Haizeng Zhang, Yuanrui Gu, Yue Deng, Congkuo Du, Changting Cui, Shuangyue Li, Wenjie Wang, Wei Kong, Jingzhou Chen, Jun Cai, Bin Geng
Summary: Vascular smooth muscle cells (VSMCs) contribute to plaque stability, and their endogenous CTH-H2S is involved in the pathogenesis of plaque stability through activation of TFEB, increasing autophagy, promoting collagen secretion, and inhibiting apoptosis.
Review
Geriatrics & Gerontology
Jing Yang, Wei Zhang, Shugeng Zhang, Ashok Iyaswamy, Jichao Sun, Jigang Wang, Chuanbin Yang
Summary: A key feature of neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of misfolded protein aggregates, which have limited effective therapeutic agents. TFEB, a regulator of lysosomal biogenesis and autophagy, plays a crucial role in protein aggregate degradation and is regarded as a promising therapeutic target for these NDs.
Review
Nutrition & Dietetics
Joseph J. Crivelli, Tanecia Mitchell, John Knight, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Sonia Fargue
Summary: The prevalence of kidney stone disease is on the rise, with calcium oxalate being the most common stone composition. Dietary oxalate intake and endogenous production of oxalate play important roles in the pathophysiology of calcium oxalate stone disease, while oxalate-degrading bacteria in the gut microbiome may mitigate stone risk.
Article
Urology & Nephrology
Megan Prochaska, John Asplin, Arlene Chapman, Elaine Worcester
Summary: The study found that men had higher calcium oxalate supersaturation in urine before RYGB, while women had higher urine calcium oxalate supersaturation and calcium phosphate supersaturation, as well as lower urine volumes after RYGB.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Review
Pharmacology & Pharmacy
Ju-Xian Song, Jia Liu, Yimin Jiang, Zi-Ying Wang, Min Li
Summary: TFEB as a master regulator of the autophagy-lysosomal pathway holds therapeutic potential for neurodegenerative disorders, with small molecules identified as TFEB activators showing promise in protecting against these diseases. Research is ongoing and the development of specific and potent TFEB activators with ideal brain bioavailability could provide a method for treating neurodegenerative disorders.
DRUG DISCOVERY TODAY
(2021)
Article
Medicine, Research & Experimental
Ling Zhou, Zeming Liu, Sichao Chen, Jing Qiu, Qianqian Li, Shipei Wang, Wei Zhou, Danyang Chen, Guang Yang, Liang Guo
Summary: The study found that autophagy mediated by TFEB plays a crucial role in fibroblast differentiation and collagen production induced by TGF-beta 1.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shiliang Jiang, Wan-Ching Chou, Linqing Tao, Zhaoyang Qiu, Ge Gao
Summary: This study explored the effects of atorvastatin on doxorubicin-induced cardiomyopathy in mice and found that it may improve cardiac function by increasing the expression of transcription factor EB to enhance lysosomal function and autophagy.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Wundersitz, Cristina Pablo Tortola, Sibylle Schmidt, Ramon Oliveira Vidal, Melanie Kny, Alexander Hahn, Lukas Zanders, Hugo A. Katus, Sascha Sauer, Christian Butter, Friedrich C. Luft, Oliver J. Mueller, Jens Fielitz
Summary: Overexpression of TFEB for the treatment of ALP-related diseases may have adverse effects on cardiac stress response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Zheng Liu, Yucong Zhang, Guoliang Sun, Wei Ouyang, Shen Wang, Hao Xu, Henglong Hu, Fan Li, Jun Yang, Zhihua Wang, Wei Guan, Xiao Yu, Zhiquan Hu, Zhong Chen, Shaogang Wang, Gongwei Long, Heng Li
Summary: Thulium laser resection of bladder tumors (TmLRBT) is a safer technique than conventional transurethral resection of bladder tumor (TURBT) in the treatment of non-muscle-invasive bladder cancer (NMIBC), with a higher detrusor identification rate and fewer postoperative complications.
UROLOGIA INTERNATIONALIS
(2022)
Article
Genetics & Heredity
Sen-Yuan Hong, Qi-Dong Xia, Jin-Zhou Xu, Chen-Qian Liu, Jian-Xuan Sun, Yang Xun, Shao-Gang Wang
Summary: This study identified 30 hub genes associated with kidney stone disease (KSD), with SPP1 being the top hub gene. These findings provide potential therapeutic targets for KSD and highlight the potential role of SPP1 in the pathogenesis of KSD.
BMC MEDICAL GENOMICS
(2022)
Article
Urology & Nephrology
Yirixiatijiang Amier, Yucong Zhang, Jiaqiao Zhang, Weimin Yao, Shaogang Wang, Chao Wei, Xiao Yu
Summary: The purpose of this study was to evaluate the preoperative risk factors for postoperative urosepsis after mini-percutaneous nephrolithotomy (mPCNL) in patients with large kidney stones. The results showed that preoperative urine leukocytes >= 450/μL were an independent risk factor for postoperative urosepsis. A predictive model was established with high discriminative ability.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Urology & Nephrology
Yuanyuan Yang, Senyuan Hong, Jinzhou Xu, Cong Li, Shaogang Wang, Yang Xun
Summary: This study explores the role of the urinary tract microbiome in the formation of calcium oxalate stones. The researchers found that Enterobacter cloacae may play an important role in this process.
Article
Urology & Nephrology
Xiaoyuan Qian, Weisong Wu, Henglong Hu, Xiao Yu, Shaogang Wang, Jianning Zhu, Jiaqiao Zhang
Summary: This study investigated the role of reactive oxygen species (ROS) from different sources in oxalate-induced renal tubular epithelial cell injury. The researchers identified potential targets for preventing or alleviating oxalate-induced cell injury.
Article
Medicine, General & Internal
Xiaoyuan Qian, Junlai Wan, Jinzhou Xu, Chenqian Liu, Mingliang Zhong, Jiaqiao Zhang, Ying Zhang, Shaogang Wang
Summary: Between 1990 and 2019, the global incidence of urolithiasis increased while the age-standardized incidence rate decreased, with mortality and DALYs increasing. The burden of urolithiasis was greater in males compared to females, showing significant differences in geographic, age, and sex distribution over the past three decades.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Xiaoyuan Qian, Chenqian Liu, Senyuan Hong, Jinzhou Xu, Can Qian, Jianning Zhu, Shaogang Wang, Jiaqiao Zhang
Summary: The use of suctioning UAS during fURL is associated with a higher stone-free rate on the first day after surgery and a lower incidence of postoperative fever or SIRS.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Metallurgy & Metallurgical Engineering
Yufeng He, Shaogang Wang, Jian Shen, Dong Wang, Yuzhang Lu, Langhong Lou, Jian Zhang
Summary: The evolution of micro-pores in a single crystal nickel-based superalloy during creep at 980 degrees C/220 MPa was investigated using X-ray computed tomography. The results show that the formation and growth of micro-pores mainly occur at the end of secondary/beginning of tertiary creep stage. The irregular large pores and high density pores located at strain concentration region are the major factors leading to creep damage. Creep failure is caused by the connection of surface cracks induced by oxidation and the internal cracks generated from growth and merging of micro-pores.
ACTA METALLURGICA SINICA-ENGLISH LETTERS
(2022)
Review
Microbiology
Sen-Yuan Hong, Qi-Dong Xia, Yuan-Yuan Yang, Cong Li, Jia-Qiao Zhang, Jin-Zhou Xu, Bao-Long Qin, Yang Xun, Shao-Gang Wang
Summary: Urolithiasis is a common disease with increasing prevalence and recurrence rate worldwide. Recent advancements in sequencing technologies and culturomics have revealed the important role of the human microbiome, both in the urinary tract and intestines, in the etiology and pathogenesis of urolithiasis.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Andrology
Taotao Sun, Wenchao Xu, Jiaxin Wang, Tao Wang, Shaogang Wang, Kang Liu, Jihong Liu
Summary: This study investigated the effect and possible mechanisms of Saxagliptin (Sax) in the treatment of diabetes mellitus-induced erectile dysfunction (DMED). The results showed that Sax could alleviate DMED by increasing SDF-1 and activating the PI3K/AKT pathway, while also mitigating endothelial dysfunction, oxidative stress, and apoptosis. This suggests that DPP-4 may be beneficial for the management of DMED.
Article
Andrology
Zhe Tang, Jingyu Song, Zhe Yu, Kai Cui, Yajun Ruan, Yang Liu, Tao Wang, Shaogang Wang, Jihong Liu, Jun Yang
Summary: This study demonstrates that miRNA-92a inhibitor can effectively inhibit oxidative stress and endothelial dysfunction in diabetic erectile dysfunction (ED), thus improving erectile function in diabetic rats.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoyan Meng, Shichao Li, Kangwen He, Henglong Hu, Cui Feng, Zhen Li, Yanchun Wang
Summary: This study evaluated the feasibility of texture analysis based on diffusion kurtosis imaging (DKI) for staging and grading bladder cancer (BC), and compared it with apparent diffusion coefficient (ADC) and biparametric vesical imaging reporting and data system (VI-RADS). The results showed that DKI-based texture analysis is useful in evaluating the staging and grading of BC, and the histogram parameters of DKI can provide additional value to VI-RADS.
BIOENGINEERING-BASEL
(2023)
Article
Andrology
Kang Liu, Taotao Sun, Wenchao Xu, Jingyu Song, Yinwei Chen, Yajun Ruan, Hao Li, Kai Cui, Yan Zhang, Yuhong Feng, Jiancheng Pan, Enli Liang, Zhongcheng Xin, Tao Wang, Shaogang Wang, Jihong Liu, Yang Luan
Summary: RLX-2 improves erectile dysfunction in rats with bilateral cavernous nerve injury by protecting cavernous nerves and endothelial function, and suppressing fibrosis and apoptosis.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Cell Biology
Chen-Qian Liu, Qi-Dong Xia, Jian-Xuan Sun, Jin-Zhou Xu, Jun-Lin Lu, Zheng Liu, Jia Hu, Shao-Gang Wang
Summary: The prognosis of bladder cancer can be predicted by analyzing immune-infiltrating cells and lncRNA expression. In this study, a prognostic signature for bladder cancer was constructed based on the infiltration of immune cells and differentially expressed immune infiltration-related lncRNAs. This signature showed good performance in predicting overall survival and was associated with immune cell subtypes.
