ActiveDriverDB: Interpreting Genetic Variation in Human and Cancer Genomes Using Post-translational Modification Sites and Signaling Networks (2021 Update)

Pan-cancer analysis of whole genomes

(2020)   NATURE

A brief history of human disease genetics

(2020) Melina Claussnitzer et al.   NATURE

Pathway and network analysis of more than 2500 whole cancer genomes

(2020) Matthew A. Reyna et al.   Nature Communications

Integrative pathway enrichment analysis of multivariate omics data

(2020) Marta Paczkowska et al.   Nature Communications

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

(2020) Arda B. Celen et al.   FEBS Journal

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1

(2019) Jian Zhang et al.   MOLECULAR CELL

ClinVar: improvements to accessing data

(2019) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

Pathogenic Germline Variants in 10,389 Adult Cancers

(2018) Kuan-lin Huang et al.   CELL

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

(2018) Kyle Ellrott et al.   Cell Systems

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

AWESOME: a database of SNPs that affect protein post-translational modifications

(2018) Yang Yang et al.   NUCLEIC ACIDS RESEARCH

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Protein SUMOylation modification and its associations with disease

(2017) Yanfang Yang et al.   Open Biology

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Impact of outdated gene annotations on pathway enrichment analysis

(2016) Lina Wadi et al.   NATURE METHODS

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

InterPro in 2017—beyond protein family and domain annotations

(2016) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

(2016) Soumil Narayan et al.   Genome Medicine

Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling

(2015) Pau Creixell et al.   CELL

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

MIMP: predicting the impact of mutations on kinase-substrate phosphorylation

(2015) Omar Wagih et al.   NATURE METHODS

Kinase inhibitors and monoclonal antibodies in oncology: clinical implications

(2015) Helen Gharwan et al.   Nature Reviews Clinical Oncology

Comprehensive assessment of cancer missense mutation clustering in protein structures

(2015) Atanas Kamburov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Reconfiguring phosphorylation signaling by genetic polymorphisms affects cancer susceptibility

(2015) Yongbo Wang et al.   Journal of Molecular Cell Biology

Sumo and the cellular stress response

(2015) Jorrit M. Enserink   Cell Division

A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces

(2015) Eduard Porta-Pardo et al.   PLoS Computational Biology

Evolutionary Constraint and Disease Associations of Post-Translational Modification Sites in Human Genomes

(2015) Jüri Reimand et al.   PLoS Genetics

Guidelines for investigating causality of sequence variants in human disease

(2014) D. G. MacArthur et al.   NATURE

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative Phosphoproteomics Reveals Extensive Cellular Reprogramming during HIV-1 Entry

(2013) Jason A. Wojcechowskyj et al.   Cell Host & Microbe

Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers

(2013) J. Reimand et al.   Molecular Systems Biology

Computational approaches to identify functional genetic variants in cancer genomes

(2013)   NATURE METHODS

The mutational landscape of phosphorylation signaling in cancer

(2013) Jüri Reimand et al.   Scientific Reports

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Phospho.ELM: a database of phosphorylation sites--update 2011

(2010) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

Detection of nonneutral substitution rates on mammalian phylogenies

(2009) K. S. Pollard et al.   GENOME RESEARCH

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

(2009) Rui Chen et al.   JOURNAL OF PROTEOME RESEARCH

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

(2009) Bernd Wollscheid et al.   NATURE BIOTECHNOLOGY

Gain and loss of phosphorylation sites in human cancer

(2008) P. Radivojac et al.   BIOINFORMATICS

The PSI-MOD community standard for representation of protein modification data

(2008) Luisa Montecchi-Palazzi et al.   NATURE BIOTECHNOLOGY

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH