Review
Biochemistry & Molecular Biology
Roberta A. Gottlieb, Honit Piplani, Jon Sin, Savannah Sawaged, Syed M. Hamid, David J. Taylor, Juliana de Freitas Germano
Summary: Mitochondrial quality control relies on various mechanisms such as selective elimination of damaged mitochondria, mitochondrial biogenesis, fusion, and fission, which are crucial for maintaining heart health.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Fajardo, Michael Coronado, Melia Matthews, Daniel Bernstein
Summary: Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Both pathological stressors like ischemia and physiological stressors like aerobic exercise can induce morphologic adaptations in mitochondria, but with different outcomes for mitochondrial health. Understanding the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors can aid in developing pharmacologic interventions for restoring cellular homeostasis.
Review
Cell Biology
Gerald W. Dorn II
Summary: This article discusses the role of mitochondrial abnormalities in the progression of amyotrophic lateral sclerosis (ALS) and explores the potential of regulating mitochondrial function to delay ALS. Experimental evidence suggests that abnormal mitochondrial fusion, fission, and transport are closely related to the pathogenesis of ALS. Moreover, it has been found that normalizing mitochondrial function can delay the development of ALS. Finally, the relative benefits of suppressing mitochondrial fusion and enhancing mitochondrial fusion in the treatment of ALS are speculated upon.
Review
Biochemistry & Molecular Biology
Yi Xia, Xu Zhang, Peng An, Junjie Luo, Yongting Luo
Summary: Vascular remodeling, characterized by abnormal proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), is a common pathological feature of many cardiovascular diseases. Emerging evidence suggests that mitochondria, as the energy center of VSMCs, play a crucial role in vascular remodeling. Maintaining mitochondrial homeostasis in VSMCs may provide a potential therapeutic target for preventing and treating pathologic vascular remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Archana Sharma, Shaniya Ahmad, Tanveer Ahmad, Shakir Ali, Mansoor Ali Syed
Summary: Mitochondria play crucial roles in biosynthesis, bioenergetics, and signaling within cells. Dysfunctions in mitochondrial dynamics may contribute to the onset and progression of lung disorders. Understanding the multifaceted regulations of mitochondrial dynamics and mitophagy could aid in the development of potential therapies for these diseases.
Review
Cardiac & Cardiovascular Systems
Xiaoqing Peng, Ruirui Hou, Yuanyuan Yang, Zhigang Luo, Yunxia Cao
Summary: This article discusses the role and current research status of mitochondrial quality control (mQC) in placental-originated preeclampsia (PE), and provides suggestions for future research, aiming to provide new ideas for the development of prevention and treatment strategies for PE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Hao Zhou, Jun Ren, Sam Toan, David Mui
Summary: Myocardial infarction is the irreversible death of cardiomyocytes due to prolonged lack of oxygen or fresh blood supply. Mitochondria, traditionally considered as energy powerhouses, are now recognized as signal regulators involved in various cellular functions. Mitochondrial quality surveillance is a network system that modifies mitochondrial structure and function through processes such as fission, fusion, biogenesis, bioenergetics, proteostasis, and degradation.
AGEING RESEARCH REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Yiyuan Yin, Haitao Shen
Summary: Mitochondria play a crucial role in maintaining normal cardiac function, but continuous damage can disrupt the balance of mitochondrial dynamics and mitophagy, leading to energy supply disorders and toxic accumulation in cardiac cells, ultimately resulting in cardiac damage and toxicity. This review highlights the importance of oxidative stress in mitophagy and aims to provide insights for preventing and treating cardiotoxicity caused by altered mitochondrial dynamics and mitophagy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vanina Romanello
Summary: Sarcopenia is a chronic disease characterized by the progressive loss of skeletal muscle mass, force, and function during aging. The decline in mitochondrial quality control pathways is a major mechanism driving aging sarcopenia, with mitochondrial dysfunction influencing whole-body homeostasis. This dysfunction releases specific myomitokines that impact healthy or unhealthy aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Lu Zhou, Wating Su, Yafeng Wang, Yuefu Zhang, Zhongyuan Xia, Shaoqing Lei
Summary: This study revealed that excessive activation of FOXO1 in the diabetic heart reduces STAT3 activation, leading to impaired mitochondrial quality control which ultimately contributes to the development of diabetic cardiomyopathy.
DIABETES OBESITY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Chen Cai, Feng Wu, Jing He, Yaoyuan Zhang, Nengxian Shi, Xiaojie Peng, Qing Ou, Ziying Li, Xiaoqing Jiang, Jiankai Zhong, Ying Tan
Summary: In diabetic cardiomyopathy (DCM), mitochondrial dysfunction plays a crucial role in disease development. Abnormal mitochondrial quality control (MQC) contributes to the accumulation of fragmented mitochondria in cardiomyocytes. This review summarizes the molecular mechanisms of MQC and discusses therapeutic approaches to improve MQC and prevent DCM progression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Longlong Gong, Bingjun Wang, Hanze Guo, Huabin Zhao, Bin Lu, Simone Engelender, He He, Zhiyin Song
Summary: Mitochondria are key organelles for oxygen sensing, while lysosomes contain hydrolytic enzymes for degradation. This study shows that under hypoxia, mitochondria engulf and degrade lysosomes, leading to the formation of large mitochondria and a process called mitochondrial self-digestion. These findings uncover a mode of communication between mitochondria and lysosomes, as well as a novel pathway for mitochondrial degradation.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Jie Li, Yu-chen Jia, Yi-xuan Ding, Jian Bai, Feng Cao, Fei Li
Summary: Ferroptosis is a form of cell death characterized by iron accumulation and excessive lipid peroxidation, which is closely associated with mitochondrial function. Mitochondrial dysfunction and damage promote oxidative stress, leading to ferroptosis. Abnormalities in mitochondrial morphology and function are closely linked to the development of various diseases. Mitochondrial homeostasis is regulated through processes such as fission, fusion, and mitophagy, which are also intimately related to ferroptosis. Understanding the dynamic regulation of mitochondrial processes during ferroptosis is crucial for studying disease development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Cell Biology
Rasha Sabouny, Timothy E. Shutt
Summary: Mitochondria are dynamic organelles that can change their function according to cellular demands. Research has shown that impairments in mitochondrial fusion and fission can impact mtDNA, but the exact relationship between remodeling mitochondrial network morphology and mtDNA remains unclear. Further studies are needed to understand this relationship and its implications for human diseases.
JOURNAL OF CELL SCIENCE
(2021)
Review
Geriatrics & Gerontology
Afzal Misrani, Sidra Tabassum, Li Yang
Summary: Mitochondria play a pivotal role in cell viability, with changes in morphology and dysfunction being closely linked to the pathogenesis of diseases like Alzheimer's. Restoring mitochondrial function can potentially delay the progression of Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Lixia Guo, Ting Zhang, Ying Xiong, Yanan Yang
Article
Biochemistry & Molecular Biology
Lixia Guo, Jingyu Wang, Ping Yang, Qiang Lu, Ting Zhang, Yanan Yang
Article
Multidisciplinary Sciences
Ting Zhang, Lixia Guo, Chad J. Creighton, Qiang Lu, Don L. Gibbons, Eunhee S. Yi, Bo Deng, Julian R. Molina, Zhifu Sun, Ping Yang, Yanan Yang
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
F. Yan, N. Shen, J. Pang, N. Zhao, B. Deng, B. Li, Y. Yang, P. Yang, J. R. Molina, S. Liu
Article
Biochemistry & Molecular Biology
Ting Zhang, Lixia Guo, Yuanyuan Wang, Yanan Yang
Article
Multidisciplinary Sciences
Wei Liu, Ting Zhang, Lixia Guo, Yuanyuan Wang, Yanan Yang
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Ting Zhang, Lixia Guo, Tao Ren, Yanan Yang
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Yang Han, Zhongliang Guo, Yanan Yang, Tao Ren
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Cell Biology
David H. Peng, Samrat T. Kundu, Jared J. Fradette, Lixia Diao, Pan Tong, Lauren A. Byers, Jing Wang, Jaime Rodriguez Canales, Pamela A. Villalobos, Barbara Mino, Yanan Yang, Rosalba Minelli, Michael D. Peoples, Christopher A. Bristow, Timothy P. Heffernan, Alessandro Carugo, Ignacio I. Wistuba, Don L. Gibbons
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Oncology
Yijiu Ren, Shujun Huang, Chenyang Dai, Dong Xie, Larry Zheng, Huikang Xie, Hui Zheng, Yunlang She, Fangyu Zhou, Yue Wang, Pengpeng Li, Ke Fei, Gening Jiang, Yang Zhang, Bo Su, E. Alejandro Sweet-Cordero, Nhan Le Tran, Yanan Yang, Jai N. Patei, Christian Rolfo, Gaetano Rocco, Andres Felipe Cardona, Alessandro Tuzi, Matteo B. Suter, Ping Yang, Wayne Xu, Chang Chen
FRONTIERS IN ONCOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Peipei Tu, Bin Huang, Minggang Li, Yaofang Zhang, Shixiang Bao, Na Tu, Yanan Yang, Jingtao Lu
Summary: Type 2 diabetes (T2D) is a complex systemic disease that might benefit from treatment with exendin-4, as shown in this study on C57BL/6 J mice. The study investigated epigenetic alterations in pancreatic tissues of diabetic mice and demonstrated an improvement in T2D progression with exendin-4 treatment through modulation of histone acetylation and methylation patterns. Understanding these epigenetic changes may lead to novel therapeutic approaches for T2D.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Immunology
Chen Chen, Aibao Chen, Yanan Yang
Summary: Vector-borne diseases pose major health threats globally, and γδT cells play a crucial role in regulating host-pathogen interactions and disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yan Li, Lihong Fan, Jianming Zheng, Xiu Nie, Yu Sun, Qin Feng, Shenyi Lian, Wenqi Bai, Weijing Cai, Yanan Yang, Bo Su, Yanfeng Xi, Dongmei Lin
Summary: This study systematically investigated the pre-screening methods and characterized the genetic and clinical features of Lynch syndrome (LS) colorectal cancers (CRCs) in Asia. The results demonstrated that MMR IHC and MSI testing were effective methods for LS pre-screening and identified previously unreported pathogenic germline variants of MMR genes in LS patients.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Yung-Hung Luo, Han Liu, Jason A. Wampfler, Henry D. Tazelaar, Yalun Li, Tobias Peikert, Dan Liu, Konstantinos Leventakos, Yuh-Min Chen, Yanan Yang, Shih-Hwa Chiou, Ping Yang
Summary: This study demonstrates that osimertinib as a second or subsequent line of treatment in patients previously treated with EGFR-TKIs without identification of T790M mutation showed a lower risk of death compared to those who received first-line or second-generation TKIs without subsequent osimertinib. Patients with EGFR mutations and PD-L1 expression >= 50% had a higher risk of treatment failure with osimertinib and worse overall survival. These results suggest that osimertinib as a second-line or subsequent treatment may be a potential alternative for patients without identification of T790M, while high PD-L1 expression is associated with poor outcomes in patients receiving osimertinib.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)