期刊
PHARMACEUTICS
卷 13, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13040436
关键词
surfactants; phospholipids; lecithins; sodium dodecyl sulfate; atomic force microscopy; corneocytes; transepidermal water loss; natural moisturizing factor; skin hydration; dermal texture index
资金
- Phospholipid Research Center Heidelberg (Germany) [CVA-2018-063/2-1]
- Research platform Characterisation of Drug Delivery Systems on Skin and Investigations of Involved Mechanisms, University of Vienna
- University of Vienna
The study evaluated the effects of pure lecithins compared to conventional surfactants on skin, with results indicating better skin tolerability with lecithin-based surfactants and encouraging further investigation.
(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux(R), skin-pH-Meter, Corneometer(R) and an Epsilon(R) sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants' skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 mu m of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation.
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