Article
Plant Sciences
Namgyu Kim, Duyoung Lee, Sais-Beul Lee, Gah-Hyun Lim, Sang-Woo Kim, Tae-Jin Kim, Dong-Soo Park, Young-Su Seo
Summary: This study examines the threat of bacterial panicle blight (BPB) caused by Burkholderia glumae to rice crops and proposes the introduction of transgenic rice plants producing the toxoflavin-degrading enzyme TxeA as a potential defense mechanism. The research highlights the complex interplay between toxoflavin, BPB, and TxeA, providing insights into crop protection and disease management. However, the complete inhibition of virulence requires further exploration.
Article
Biochemistry & Molecular Biology
Yang Si, Chloe Grazon, Gilles Clavier, Jean-Frederic Audibert, Bianca Sclavi, Rachel Meallet-Renault
Summary: A novel strategy is proposed to remove the emission of fluorescent nanoparticles during bacteria imaging by using methylene blue, offering a new approach to improve image accuracy in bioimaging.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Camila Maurmann de Souza, Osmel Fleitas Martinez, Harry Morales Duque, Octavio Luiz Franco
Summary: Novel treatments are needed to combat resistant Gram-negative bacteria and predatory bacteria have emerged as a potential solution. However, the efficacy of predatory bacteria alone is limited, leading to the investigation of combination therapies with other agents. This article discusses recent advancements in the use of predatory bacteria for infections and proposes novel combination strategies with antivirulence compounds.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Physical
Ruxin Li, Juan Zheng, Yule Wang, Wenjun Bai, Yang Lu, Jiahou Geng, Jiahe Feng, Ning Wang, Yufen Zhao, Jinhui Wang
Summary: This study presents a novel NTR-responsive turnoff fluorescent probe, TPEDCH-PBN, based on AIEgen. The probe shows high selectivity towards NTR and has a detection limit of 0.68 μg/mL. Computational calculations and docking studies were employed to determine the structure-function relationship between the probe and NTR. Cell imaging experiments confirmed the NTR detection ability of the probe.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Immunology
Hidetada Hirakawa, Kazutomo Suzue, Haruyoshi Tomita
Summary: The Tol/Pal system is a set of protein complexes produced by Gram-negative bacteria, playing essential roles in colicin uptake, pathogenesis, and cell growth. It is proposed as a potential target for antimicrobial chemotherapy and vaccine development due to its immunogenicity and ability to stimulate immune responses.
Article
Plant Sciences
Guang-Dong Zhou, Ping He, Libo Tian, Shengtao Xu, Baoming Yang, Lina Liu, Yongfen Wang, Tingting Bai, Xundong Li, Shu Li, Si-Jun Zheng
Summary: Fusarium wilt, especially TR4, is a major constraint for banana production. Isotianil, an elicitor, can effectively alleviate the symptoms of TR4 and induce resistance in banana plants. It also affects starch accumulation and the expression of key genes related to plant defense and starch synthesis.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shereen M. Hamdy, Amal W. Danial, Eman M. Halawani, Ahmed A. M. Shoreit, Abd El-Latif Hesham, Sanaa M. F. Gad El-Rab
Summary: This study describes wound dressing materials made from biodegradable polyhydroxybutyrate (PHB) combined with AgNPs and gelatin (AgNPs/Gelatin/PHB). The results show that AgNPs/Gelatin/PHB exhibits excellent antimicrobial efficacy against bacteria and facilitates a better wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Microbiology
Megan G. Taggart, William J. Snelling, Patrick J. Naughton, Roberto M. La Ragione, James S. G. Dooley, Nigel G. Ternan
Summary: Clostridiodes difficile is ranked as an urgent threat by CDC due to its prevalence in healthcare settings and its association with antibiotic-associated gastrointestinal diseases. The role of biofilm formation in the pathogenesis of C. difficile infection is still not fully understood, but it is believed to play a significant role in disease recurrence. Various factors, such as motility and adhesion, influence biofilm formation in C. difficile, making the regulatory system complex and multifactorial. Further research is needed to better understand biofilm regulation in different strains of C. difficile and its implications for disease management.
Article
Chemistry, Physical
Ilaria Berruti, Maria Inmaculada Polo-Lopez, Isabel Oller, Jenny Flores, M. Luisa Marin, Francisco Bosca
Summary: The reactivity of sulfate radicals (SO4 center dot-) against gram-negative and gram-positive bacteria, as well as some Contaminants of Emerging Concern (CECs), was investigated using laser flash photolysis (LFP) technique. The results revealed that SO4 center dot- reacted with cell-wall components of bacteria through a H-abstraction mechanism, while the reaction with aromatic amino acids (AAA) only present in Porins of gram-negative outer-membrane involved electron transfer processes. Moreover, the reactivity of SO4 center dot- towards CECs also followed an electron transfer mechanism. Interestingly, the removal of bacteria and CECs at pilot plant scale by UV-C/SO4 center dot- was consistent with the reactivity determined using LFP.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Plant Sciences
Fida Alo, Anupalli Roja Rani, Michael Baum, Sarvjeet Singh, Zakaria Kehel, Upasana Rani, Sripada Udupa, Khaled Al-Sham'aa, Alsamman M. Alsamman, Tawffiq Istanbuli, Basem Attar, Aladdin Hamwieh, Ahmed Amri
Summary: This study used genotyping-by-sequencing to identify genomic regions associated with Ascochyta blight resistance in chickpea. Multiple genomic regions were found to be linked to resistance, with many genes associated with stress and disease resistance. This research has significant implications for breeding resistant chickpea varieties.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Chemical
Yuzhe Cao, Zhijun Zhou, Tongyu Zhang, Zejuan Ni, Bo Ge, Hao Zhang, Guina Ren, Xin Shao, Zhaozhu Zhang
Summary: A solar-driven photothermal evaporation device with salt-resistance and the ability to remove dye and oil slicks has been developed to overcome the limitations of existing devices. The device uses a superhydrophobic part to eliminate dye and oil slicks, protecting both the device and the environment. It achieves a purification efficiency of over 99.9% for heavy metal ions and Rh B solution. The device also demonstrates high evaporation rates under one sun illumination for different water sources, indicating its potential for desalination and wastewater purification.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Infectious Diseases
Laiba Shafique, Siwen Wu, Amjad Islam Aqib, Muhammad Muddassir Ali, Misbah Ijaz, Muhammad Aamir Naseer, Zaeem Sarwar, Rais Ahmed, Arslan Saleem, Qudratullah, Abdullah Saghir Ahmad, Hongping Pan, Qingyou Liu
Summary: The study showed that antibiotic-resistant bacteria, particularly Escherichia coli, were the main pathogens causing bovine endometritis, with a high prevalence rate. Most of the bacteria exhibited resistance to a wide range of antibiotics. Gentamicin combined with enrofloxacin and single treatment with gentamicin showed the highest recovery rate in field trials.
Article
Multidisciplinary Sciences
Jian Ji, Shang Wu, Lina Sheng, Jiadi Sun, Yongli Ye, Yiyun Zhang, Yinzhi Zhang, Yajun Gong, Jianzhong Zhou, Xiulan Sun
Summary: The study utilized the LC-MS/MS metabolomics platform to analyze the metabolic profiles of 138 strains of Salmonella, and found that these profiles were related to the serotypes, sources, processing stages, and antibiotic resistance patterns of the bacteria. Specifically, Salmonella Derby with drug resistance to ceftriaxone exhibited a different metabolic status with changes in glutathione biosynthesis. Exogenous glutathione oxidized or citrulline, but not glutathione reduced, restored the susceptibility of multidrug-resistant Salmonella Derby to ceftriaxone. This study establishes a strategy based on functional metabolomics to manage the survival of antibiotic-resistant bacteria.
Article
Biochemistry & Molecular Biology
Manal A. Alossaimi, Heba Elmansi, Mai Alajaji, Ali Altharawi, Abdulmalik S. A. Altamimi, Galal Magdy
Summary: A novel spectrofluorimetric method for determining dacomitinib based on newly synthesized nitrogen-doped carbon quantum dots (N-CQDs) as fluorescent probes is proposed in this study. The method is simple, does not require pretreatment, and showed high sensitivity with a low detection limit of 0.11 μg/mL. The synthesized N-CQDs demonstrated stable spherical shapes, narrow size distribution, and high fluorescence quantum yield (25.3%).
Editorial Material
Cell Biology
Howard C. Crawford
Summary: PDAC, one of the deadliest cancers, is characterized by oncogenic mutations in the KRAS gene. Targeting KRAS directly has been challenging, but recent success in certain mutants indicates a promising new era in therapy. Understanding resistance mechanisms to KRAS inhibitors is crucial for improving PDAC treatment outcomes.
GENES & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Yeyeong Lee, Okhee Choi, Byeongsam Kang, Juyoung Bae, Seunghoe Kim, Jinwoo Kim
SCIENTIFIC REPORTS
(2020)
Article
Plant Sciences
Okhee Choi, Seunghoe Kim, Byeongsam Kang, Yeyeong Lee, Juyoung Bae, Jinwoo Kim
Summary: This study analyzed the genetic diversity of Korean B. glumae isolates, revealing that the isolates were divided into 11 clusters and three divisions, with most of the pigment-producing isolates grouped in divisions II and III.
Article
Microbiology
Okhee Choi, Byeongsam Kang, Yongsang Lee, Yeyeong Lee, Jinwoo Kim
Summary: Carotenoids are widely used in various industries, with this study focusing on characterizing carotenoid biosynthetic genes in the plant-pathogenic bacterium Pantoea ananatis. Through genetic engineering, different carotenoids were produced to confer tolerance to UV radiation and toxoflavin. The molecular mechanism behind carotenoid production in P. ananatis was elucidated, showing a complex regulatory network involving key genes and signaling pathways.
Article
Microbiology
Dimas Hand Vidya Paradhipta, Young Ho Joo, Hyuk Jun Lee, Seong Shin Lee, Hyeon Tak Noh, Jeong Seok Choi, Jinwoo Kim, Hyeong Gyu Min, Sam Churl Kim
Summary: The study found that inoculants can improve the quality of corn silage and extend its resistance against mold contamination at feed-out phase. Using a mixed inoculant shows better effects.
Article
Plant Sciences
Okhee Choi, Byeongsam Kang, Yeyeong Lee, Seunghoe Kim, Jin-Hyeuk Kwon, Jong-Tae Lee, Jinwoo Kim
Summary: In 2018, a bacterial disease complex was found on onion seedlings in Changnyeong, South Korea, consisting of bleached spots and soft rot-blight. Four bacteria were identified - Pseudomonas viridiflava, Acidovorax avenae subsp. avenae, Pantoea ananatis, and Xanthomonas axonopodis. The interactions among these strains were mostly antagonistic or neutral under different temperature conditions.
Article
Plant Sciences
Okhee Choi, Yeyeong Lee, Byeongsam Kang, Seunghoe Kim, Jinwoo Kim
Summary: This study identified Pseudomonas sp. as the causative pathogen of leaf blight on Sansevieria cylindrica, marking the first report of such disease in South Korea. The identification was based on various tests and phylogenetic analysis using gene sequences, shedding light on the pathogen involved in this disease outbreak.
AUSTRALASIAN PLANT DISEASE NOTES
(2021)
Article
Biotechnology & Applied Microbiology
Okhee Choi, Jaeyeong Cho, Byeongsam Kang, Yeyeong Lee, Jinwoo Kim
Summary: This study identified the essential role of two siderophores, aerobactin and desferrioxamine E, in the antibacterial activity of P. ananatis PA13. The biosynthetic gene clusters of these siderophores were found to be negatively regulated by the Fur protein. Siderophore production was not required for P. ananatis virulence in plants, but it appears to be involved in the microbial ecology surrounding the plant environment.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Changhoon Lee, Ho Jin Youn, Sang-Hoon Lee, Jinwoo Kim, Daeyoung Son, Joon-Yung Cha
Summary: This study investigated the positive role of plant Aha in heat stress tolerance through chaperone properties and/or activation of Hsp90 to protect substrate proteins from thermal injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Maureen C. Onyeziri, Ramya Natarajan, Gail G. Hardy, Jing Xu, Ian P. Reynolds, Jinwoo Kim, Peter M. Merritt, Thomas Danhorn, Michael E. Hibbing, Alexandra J. Weisberg, Jeff H. Chang, Clay Fuqua
Summary: Agrobacterium tumefaciens, a type of bacteria that infects plants and associates with various surfaces, produces a polysaccharide called UPP in two distinct forms, each requiring a specific polymerase. These findings have important implications for understanding polysaccharide biosynthesis mechanisms.
MOLECULAR MICROBIOLOGY
(2022)
Article
Microbiology
Minhee Kang, Jae Yun Lim, Jinwoo Kim, Ingyu Hwang, Eunhye Goo
Summary: Bacteria adapt to harsh environments by changing their genetic and physiological traits. A study on Burkholderia glumae strains found that genomic diversity is linked to the ability to adapt to different environments. The study also revealed a correlation between genomic structures and spontaneous mutations in a master regulator gene, as well as nutritional conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Okhee Choi, Yeyeong Lee, Byeongsam Kang, Jinwoo Kim
Summary: Toxoflavin contamination in broken rice produced by domestic rice processing complexes in South Korea was investigated in 2011. Out of the 68 complexes investigated, 12 were confirmed to have toxoflavin contamination in three provinces: Gangwon, Gyeonggi, and Gyeongsang. Burkholderia glumae was identified as the toxoflavin-producing bacteria in the rice samples collected from these complexes. The toxoflavin-producing ability varied among the 25 bacterial isolates, but all of them inhibited rice seed germination and induced seed rot. This study provides important baseline data for managing toxoflavin contamination in rice storage and processing.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Okhee Choi, Yeyeong Lee, Byeongsam Kang, Su Kyung Cho, Yongsung Kang, Dong-Wan Kang, Seul-Bi Lee, Sung-Mun Bae, Jinwoo Kim
Summary: This study isolated lactic acid bacteria (LAB) from the gut of a pest called Riptortus pedestris and found that these LAB have the ability to survive under gastrointestinal conditions and have beneficial effects on the insect host. Feeding the LAB increased the survival rate of the insects, but did not affect their weight or length. These findings provide fundamental information about the symbiotic relationship between insects and LAB, as well as a novel concept for pest control.
Article
Plant Sciences
Okhee Choi, Byeongsam Kang, Yeyeong Lee, Seunghoe Kim, Jonghee Oh, Hongsup Kim, Jinwoo Kim
AUSTRALASIAN PLANT DISEASE NOTES
(2020)
Article
Plant Sciences
Okhee Choi, Yeyeong Lee, Byeongsam Kang, Seunghoe Kim, Jinwoo Kim
AUSTRALASIAN PLANT DISEASE NOTES
(2020)