Review
Biochemistry & Molecular Biology
Xin Zhang, Stephane Melik-Parsadaniantz, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Nathan Moreau
Summary: The cornea, a crucial part of the eye, requires constant renewal and efficient healing to maintain ocular homeostasis. The Hedgehog signaling pathway plays a vital role in corneal wound healing, promoting cell proliferation, migration, and maintenance of the corneal epithelial barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Chi-Chin Sun, Shao-Yun Lee, Li-Hsien Chen, Chia-Hui Lai, Zhao-Qing Shen, Nan-Ni Chen, Yi-Shyun Lai, Chien-Yi Tung, Tsai-Yu Tzeng, Wen-Tai Chiu, Ting-Fen Tsai
Summary: Chronic epithelial defects of the cornea, often associated with dry eye disease, diabetes, chemical injuries, etc., are an unmet clinical need. The decreased expression of CISD2 protein in the corneal epithelium of patients with corneal epithelial diseases highlights its importance in corneal repair. Targeting Ca2+-dependent pathways can improve corneal epithelial regeneration. A review on the role of CISD2 in corneal repair and the potential of repurposing FDA-approved drugs that target Ca2+-dependent pathways for treating chronic epithelial defects of the cornea is provided.
CELLULAR SIGNALLING
(2023)
Review
Pharmacology & Pharmacy
Vishal Jhanji, Isabelle Billig, Gary Hin-Fai Yam
Summary: Corneal opacification is the fourth most common cause of blindness globally. The standard treatment for serious corneal scarring is corneal transplantation, but there are limitations such as long-term graft survival and the lifelong use of immunosuppressants. Research is focused on finding new technologies to modulate wound healing and prevent corneal opacification.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Qingyi Jia, Hanxing Zhao, Yixi Wang, Ying Cen, Zhenyu Zhang
Summary: Wound healing is a complex process that involves multiple phases, including inflammation, proliferation, and remodeling. Abnormal inflammation can impede wound healing under certain pathological conditions. Adipose-derived stem cells (ADSCs) and their secreted extracellular vesicles (ADSC-EVs) have shown potential in promoting wound healing by inhibiting abnormal inflammation responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nyemkuna Fortingo, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky, Wendy B. Bollag
Summary: Inflammation plays a complex role in corneal wound healing. While acute inflammation is necessary to prevent infection, chronic or excessive inflammation can delay healing and worsen outcomes. Reductions in severe or chronic inflammation lead to better corneal clarity, thickness, and healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Hui Lv, Hanxiao Liu, Ting Sun, Han Wang, Xiao Zhang, Wei Xu
Summary: A wound occurs when the skin's epidermis and dermis are damaged internally and externally. The traditional method of wound healing is unsatisfactory, causing extended treatment time and increased cost for patients. Therefore, there is an urgent need for a new method to accelerate wound healing. Exosome derived from stem cell (EdSC), a cell-free therapy, offers promising possibilities for wound healing by participating in various stages of the healing process.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Yijia Huang, Ting Fu, Xinwei Jiao, Sijing Liu, Yunxia Xue, Jun Liu, Zhijie Li
Summary: This study found that deficient thyroid hormone secretion significantly affects corneal homeostasis and post-wound repair processes, and topical T3 administration might have a potential reversal effect on delayed corneal wound repair among hypothyroid individuals.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jin Suk Ryu, So Yeon Kim, Mee Kum Kim, Joo Youn Oh
Summary: Recent evidence suggests that epithelial stem/progenitor cells in barrier tissues retain a memory of previous injuries, enabling faster restoration of the barrier after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, also shows signs of inflammatory memory. Mice and ocular Sjogren's syndrome patients both exhibited accelerated corneal wound healing and reduced inflammation after subsequent injuries, indicating the presence of nonspecific inflammatory memory in the cornea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Di Zhu, Junwen Wang, Yingwei Wang, Yi Jiang, Shiqiang Li, Xueshan Xiao, Panfeng Wang, Qingjiong Zhang
Summary: This study describes the variant landscape of 15 genes responsible for corneal dystrophies (CDs) in Chinese families. Pathogenic or likely pathogenic variants were detected in 4 of the 15 genes in 30 of the 37 families with CDs. Comparative analysis revealed that some previously reported variants are unlikely causative of CDs. The study highlights the importance of understanding frequently misinterpreted variants in genomic medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Brent Ju, Owen Guo, Dathe Z. Benissan-Messan, McKinley H. Shawver, Peng Chen, Bingchuan Geng, Siqi Wei, Jordan R. Yaron, Alexandra R. Lucas, Hua Zhu
Summary: The study shows that Serp-1 facilitates corneal wound healing by reducing fibrosis and neovascularization. It effectively mitigates inflammation with no noticeable harm related to its application.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Junjie Huang, Hanxu Chen, Ning Li, Luoran Shang, Yan Bi, Yuanjin Zhao
Summary: In this paper, a novel herringbone microfluidic bioreactor with cell microcarriers integration was proposed for batch-preparation of stem cell exosomes. The microfluidic device provided a controllable fluidic environment for stem cells culturing on microcarriers and for exosomes secretion, leading to a high yield of exosomes. The exosomes harvested from the bioreactor showed excellent promoting effect on wound healing.
Article
Cell & Tissue Engineering
Meri Vattulainen, Tanja Ilmarinen, Taina Viheriala, Vilma Jokinen, Heli Skottman
Summary: Functional limbal stem cells (LSCs) were successfully differentiated from human pluripotent stem cells (hPSCs), showing similar marker expression and wound healing capacity to tissue-derived LSCs. Post-thaw hPSC-LSCs exhibited a robust response to the injury-associated signal mediator ATP and demonstrated higher wound healing capacity compared to tissue-derived LSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Ophthalmology
Madeline E. Bhend, Duraisamy Kempuraj, Nishant R. Sinha, Suneel Gupta, Rajiv R. Mohan
Summary: Aquaporins (AQPs) are transmembrane water channel proteins that regulate corneal hydration and transparency. They play a crucial role in keratocyte function, inflammation, edema, angiogenesis, and the wound healing process in the cornea. Deficiency of AQPs can lead to abnormal wound healing and impaired osmolar homeostasis. This review discusses the role of AQPs in corneal homeostasis, wound repair, and their potential as therapeutic targets for corneal injuries.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Chi-Chin Sun, Shao-Yun Lee, Cheng-Heng Kao, Li-Hsien Chen, Zhao-Qing Shen, Chia-Hui Lai, Tsai-Yu Tzeng, Jong-Hwei Su Pang, Wen-Tai Chiu, Ting-Fen Tsai
Summary: The findings illustrate the crucial role of Cisd2 in the cornea and suggest that targeting the Ca2+ signaling pathway could be a potential therapeutic strategy for corneal epithelial diseases.
