Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology

Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial

(2020) Felix Eckstein et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of Inflammation in the Pathogenesis of Osteoarthritis

(2020) Yoke Yue Chow et al.   MEDIATORS OF INFLAMMATION

Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis

(2020) R.E. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Identifying effector molecules, cells, and cytokines of innate immunity in OA

(2020) M.H.J. van den Bosch et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns

(2020) Francis Berenbaum et al.   POSTGRADUATE MEDICINE

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

(2020) Karolina Kania et al.   Scientific Reports

Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin

(2020) Shan Huang et al.   Scientific Reports

The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

(2020) Fu-Xing-Zi Li et al.   Frontiers in Endocrinology

Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

(2020) Dominique Muschter et al.   BONE

Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

(2020) Daniel Richard et al.   CELL

Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats

(2020) Koji Aso et al.   OSTEOARTHRITIS AND CARTILAGE

Lorecivivint, a Novel Intra‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial

(2020) Yusuf Yazici et al.   Arthritis & Rheumatology

TNIIIA2, The Peptide of Tenascin-C, as a Candidate for Preventing Articular Cartilage Degeneration

(2020) Tetsuya Hattori et al.   Cartilage

Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model

(2020) Naoko Araya et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis

(2020) Hiroyuki Nakamura et al.   Scientific Reports

Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis

(2020) Keita Nagira et al.   Scientific Reports

Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

(2020) Lei He et al.   Stem Cell Research & Therapy

Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial

(2020) Pascal Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip

(2020) Rasmus Klose-Jensen et al.   BMC MUSCULOSKELETAL DISORDERS

Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis

(2020) Meng Feng et al.   BONE

Lorecivivint, an intra-articular potential disease-modifying osteoarthritis drug

(2020) Marwa Sabha et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Analysis of spatial osteochondral heterogeneity in advanced knee osteoarthritis exposes influence of joint alignment

(2020) Sophie Haberkamp et al.   Science Translational Medicine

Cartilage Oligomeric Matrix Protein–Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

(2020) Enrique Andrés Sastre et al.   Cartilage

Osteoarthritis year in review: genetics, genomics, epigenetics

(2020) A. Ratneswaran et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of the Biomarkers and Pathological Process of Osteoarthritis: Weighted Gene Co-expression Network Analysis

(2019) Hui-Yun Gu et al.   Frontiers in Physiology

Potential candidate biomarkers associated with osteoarthritis: Evidence from a comprehensive network and pathway analysis

(2019) Rongqiang Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The extracellular matrix as a multitasking player in disease

(2019) Achilleas D. Theocharis et al.   FEBS Journal

Inhibition of MMPs and ADAM/ADAMTS

(2019) Charles J. Malemud   BIOCHEMICAL PHARMACOLOGY

Correlation between synovial fluid cytokine concentrations and limb function in normal dogs and in dogs with lameness from spontaneous osteoarthritis

(2019) Philip I. Allen et al.   VETERINARY SURGERY

Association of CCL2 Gene Variants With Osteoarthritis in a Chinese Han Population

(2019) Zhonghua Xu et al.   ARCHIVES OF MEDICAL RESEARCH

Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis

(2019) Takumi Sakamoto et al.   BMC MUSCULOSKELETAL DISORDERS

Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons

(2019) Alex Bersellini Farinotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Establishing outcome measures in early knee osteoarthritis

(2019) Carolyn A. Emery et al.   Nature Reviews Rheumatology

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

(2019) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Emerging Trend in the Pharmacotherapy of Osteoarthritis

(2019) Wei Zhang et al.   Frontiers in Endocrinology

Wnt signaling: a promising target for osteoarthritis therapy

(2019) Yudan Wang et al.   Cell Communication and Signaling

Topographic modeling of early human osteoarthritis in sheep

(2019) Tamás Oláh et al.   Science Translational Medicine

Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis

(2019) Jana Riegger et al.   Cell Death & Disease

Effects of Sprifermin, IGF1, IGF2, BMP7, or CNP on Bovine Chondrocytes in Monolayer and 3D Culture

(2019) Sylvia Müller et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review

(2019) El-Sayed E. Mehana et al.   LIFE SCIENCES

Identification of antibodies against extracellular matrix proteins in human osteoarthritis

(2018) Johannes Ruthard et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis

(2018) Yuya Kawarai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cartilage oligomeric matrix protein: COMPopathies and beyond

(2018) Karen L. Posey et al.   MATRIX BIOLOGY

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Recombinant Extracellular Matrix Protein Fragments Support Human Embryonic Stem Cell Chondrogenesis

(2018) Aixin Cheng et al.   TISSUE ENGINEERING PART A

Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone

(2018) Takashi Hoshino et al.   BMC MUSCULOSKELETAL DISORDERS

Modern-day environmental factors in the pathogenesis of osteoarthritis

(2018) Francis Berenbaum et al.   Nature Reviews Rheumatology

Interleukin-1β signaling in osteoarthritis – chondrocytes in focus

(2018) Zsuzsa Jenei-Lanzl et al.   CELLULAR SIGNALLING

Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis

(2018) Yichao Wan et al.   CURRENT MEDICINAL CHEMISTRY

Catirlage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis

(2018) H.Q. Hao et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

(2018) Shouan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene

(2017) S.C. Warner et al.   EUROPEAN JOURNAL OF PAIN

Peripheral Nerve Fibers and Their Neurotransmitters in Osteoarthritis Pathology

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pain-related behavior and the characteristics of dorsal-root ganglia in a rat model of hip osteoarthritis induced by mono-iodoacetate

(2017) Shuichi Miyamoto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis

(2017) M.H. van den Bosch et al.   OSTEOARTHRITIS AND CARTILAGE

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix

(2017) A. Gigout et al.   OSTEOARTHRITIS AND CARTILAGE

Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays

(2017) P. Lorenzo et al.   OSTEOARTHRITIS AND CARTILAGE

A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study

(2017) Y. Yazici et al.   OSTEOARTHRITIS AND CARTILAGE

Location-independent analysis of structural progression of osteoarthritis—Taking it all apart, and putting the puzzle back together makes the difference

(2017) Felix Eckstein et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

COMP-assisted collagen secretion – a novel intracellular function required for fibrosis

(2016) Jan-Niklas Schulz et al.   JOURNAL OF CELL SCIENCE

Attenuation of cartilage degeneration by calcitonin gene-related paptide receptor antagonist via inhibition of subchondral bone sclerosis in osteoarthritis mice

(2016) Tomoyuki Nakasa et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Early OA: point of no return or a chance for regenerative approaches

(2016) Peter Angele et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Early osteoarthritis of the knee

(2016) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Correlation between neuropeptide distribution, cancellous bone microstructure and joint pain in postmenopausal women with osteoarthritis and osteoporosis

(2016) Jie Xiao et al.   NEUROPEPTIDES

Nociceptive phenotype alterations of dorsal root ganglia neurons innervating the subchondral bone in osteoarthritic rat knee joints

(2016) K. Aso et al.   OSTEOARTHRITIS AND CARTILAGE

Predominance of synovial sensory nerve fibers in arthrofibrosis following total knee arthroplasty compared to osteoarthritis of the knee

(2016) Franz Xaver Koeck et al.   Journal of Orthopaedic Surgery and Research

Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models

(2016) Yuriyo Matsui et al.   Cartilage

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Changes in peptidergic fiber density in the synovium of mice with collagenase-induced acute arthritis

(2015) Kohei Murakami et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

What Are the Prognostic Factors for Radiographic Progression of Knee Osteoarthritis? A Meta-analysis

(2015) Alex N. Bastick et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Calcitonin gene-related peptide can be selected as a predictive biomarker on progression and prognosis of knee osteoarthritis

(2015) Tianhua Dong et al.   INTERNATIONAL ORTHOPAEDICS

Expression profles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis

(2015) Masatoshi Komatsu et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

A novel rat model of hip pain by intra-articular injection of nerve growth factor-characteristics of sensory innervation and inflammatory arthritis

(2015) Takanori Omae et al.   Modern Rheumatology

OARSI Clinical Trials Recommendations: Key analytic considerations in design, analysis, and reporting of randomized controlled trials in osteoarthritis

(2015) E. Losina et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone turnover, but not bone volume, is increased in early stage osteoarthritic lesions in the human hip joint

(2015) R. Klose-Jensen et al.   OSTEOARTHRITIS AND CARTILAGE

Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014

(2015) Felix Eckstein et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Relationship Between Medial Meniscal Extrusion and Cartilage Loss in Specific Femorotibial Subregions: Data From the Osteoarthritis Initiative

(2015) K. Bloecker et al.   ARTHRITIS CARE & RESEARCH

Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip

(2015) Hui Wang et al.   ARTHRITIS RESEARCH & THERAPY

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

(2015) Sophie Lees et al.   Arthritis & Rheumatology

CCN1 (Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 (Aggrecanase 1) Activity

(2015) Miyuki Chijiiwa et al.   Arthritis & Rheumatology

A homeostatic function of CXCR2 signalling in articular cartilage

(2014) Joanna Sherwood et al.   ANNALS OF THE RHEUMATIC DISEASES

COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins

(2014) Johannes Ruthard et al.   CONNECTIVE TISSUE RESEARCH

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

(2014) M Cucchiarini et al.   GENE THERAPY

Novel Cartilage Oligomeric Matrix Protein (COMP) Neoepitopes Identified in Synovial Fluids from Patients with Joint Diseases Using Affinity Chromatography and Mass Spectrometry

(2014) Emma Åhrman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics

(2014) D.P. Tonge et al.   OSTEOARTHRITIS AND CARTILAGE

Identifying and Treating Preclinical and Early Osteoarthritis

(2014) David T. Felson et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

(2014) Susanne Grässel   ARTHRITIS RESEARCH & THERAPY

Inhibition of Chondrocyte and Synovial Cell Death After Exposure to Commonly Used Anesthetics

(2013) Allison J. Rao et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Epidemiology and burden of osteoarthritis

(2013) A. Litwic et al.   BRITISH MEDICAL BULLETIN

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study

(2012) Leena Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: Findings from the multicenter osteoarthritis study and the osteoarthritis initiative

(2012) David T. Felson et al.   ARTHRITIS AND RHEUMATISM

Pathophysiology of peri-articular bone changes in osteoarthritis

(2012) H. Weinans et al.   BONE

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Etiology of osteoarthritis: genetics and synovial joint development

(2012) Linda J. Sandell   Nature Reviews Rheumatology

Definition and classification of early osteoarthritis of the knee

(2011) Frank P. Luyten et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Biological aspects of early osteoarthritis

(2011) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The Basic Science of Human Knee Menisci

(2011) Alice J. S. Fox et al.   Sports Health-A Multidisciplinary Approach

Varus and valgus alignment and incident and progressive knee osteoarthritis

(2010) L. Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

Anticytokine Therapy for Osteoarthritis

(2010) Charles J. Malemud   DRUGS & AGING

Intra-articular injections of bone morphogenetic protein-7 retard progression of existing cartilage degeneration

(2010) Masaya Hayashi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The basic science of the subchondral bone

(2010) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

(2010) Michaela Durigova et al.   MATRIX BIOLOGY

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

A Randomized Trial of Treatment for Acute Anterior Cruciate Ligament Tears

(2010) Richard B. Frobell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Terminology of osteoarthritis cartilage and bone histopathology – a proposal for a consensus

(2010) K.P.H. Pritzker et al.   OSTEOARTHRITIS AND CARTILAGE

Alignment, body mass and their interaction on dynamic knee joint load in patients with knee osteoarthritis

(2010) R.F. Moyer et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

Suprastructures of extracellular matrices: paradigms of functions controlled by aggregates rather than molecules

(2009) Peter Bruckner   CELL AND TISSUE RESEARCH

Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes

(2009) Andreas R. Klatt et al.   FEBS LETTERS

The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period

(2009) M.D. Crema et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor

(2008) M.R. Howard et al.   NEUROPEPTIDES

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

(2008) James Melrose et al.   ARTHRITIS RESEARCH & THERAPY

Fragments of extracellular matrix as mediators of inflammation

(2007) T ADAIRKIRK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY