IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

(2020) Laura Strauss et al.   Science Immunology

Interleukin‐6‐mediated resistance to immunotherapy is linked to impaired myeloid cell function

(2020) Elham Beyranvand Nejad et al.   INTERNATIONAL JOURNAL OF CANCER

Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models

(2020) Marit van Elsas et al.   Journal for ImmunoTherapy of Cancer

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

(2020) Elham Beyranvand Nejad et al.   Journal for ImmunoTherapy of Cancer

Interleukin 6 (IL-6) promotes Brucella abortus clearance by controlling bactericidal activity of macrophages and CD8+ T cell differentiation

(2019) Huynh Tan Hop et al.   INFECTION AND IMMUNITY

Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment

(2018) Hirotake Tsukamoto et al.   CANCER RESEARCH

Immune checkpoint blockade combined with IL-6 and TGF-β inhibition improves the therapeutic outcome of mRNA-based immunotherapy

(2018) Lukasz Bialkowski et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting Interleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model

(2018) Jibin Li et al.   MEDICAL SCIENCE MONITOR

Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement

(2016) Rashmi Bharti et al.   CANCER LETTERS

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer

(2016) Thomas A Mace et al.   GUT

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

(2016) Sylvia Heink et al.   NATURE IMMUNOLOGY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site

(2015) Maxime Thoreau et al.   Oncotarget

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression

(2015) T. C. van der Sluis et al.   Cancer Immunology Research

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

(2014) Ceri A. Fielding et al.   IMMUNITY

Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis

(2014) JAN SOMMER et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and functionin vitroandin vivo

(2013) Christina E. Arnold et al.   IMMUNOLOGY

Cytokine patterns in patients with cancer: a systematic review

(2013) Bodo E Lippitz   LANCET ONCOLOGY

Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis

(2013) Berit Carow et al.   PLoS Pathogens

Vaccine-Induced Effector-Memory CD8+ T Cell Responses Predict Therapeutic Efficacy against Tumors

(2012) S. van Duikeren et al.   JOURNAL OF IMMUNOLOGY

Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2

(2012) Sharon Cohen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii

(2011) Ryan J. Whitmarsh et al.   Cell Host & Microbe

Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer

(2011) Jermaine Coward et al.   CLINICAL CANCER RESEARCH

Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells

(2010) Yue Wang et al.   CANCER LETTERS

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

(2009) Roland Axmann et al.   ARTHRITIS AND RHEUMATISM

The immunologic constant of rejection

(2008) Ena Wang et al.   TRENDS IN IMMUNOLOGY