Receptor-ligand supplementation via a self-cleaving 2A peptide–based gene therapy promotes CNS axonal transport with functional recovery

Molecular actions of NLR immune receptors in plants and animals

(2020) Jizong Wang et al.   Science China-Life Sciences

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

(2020) Patrick Yu-Wai-Man et al.   Science Translational Medicine

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

(2019) Tasneem Z. Khatib et al.   CURRENT EYE RESEARCH

The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis

(2019) Jonu Pradhan et al.   Frontiers in Cellular Neuroscience

A single combination gene therapy treats multiple age-related diseases

(2019) Noah Davidsohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

(2019) Xavier Hadoux et al.   Nature Communications

Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons

(2018) Andrew Osborne et al.   HUMAN GENE THERAPY

Retinal AAV8- RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery

(2018) Catherine Cukras et al.   MOLECULAR THERAPY

Safety of rAAV2/2- ND4 Gene Therapy for Leber Hereditary Optic Neuropathy

(2018) Catherine Vignal et al.   OPHTHALMOLOGY

Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma

(2018) Michael L. Risner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor/tropomyosin-related kinase receptor-B signaling

(2018) Andrew Osborne et al.   Cell Death & Disease

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

(2017) Marius Chiasseu et al.   Molecular Neurodegeneration

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration

(2017) Sujeong Yang et al.   NEUROBIOLOGY OF AGING

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

(2017) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway

(2016) Vicki Chrysostomou et al.   AGING CELL

Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells

(2016) Kate E. Binley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Axonal transport along retinal ganglion cells is grossly intact during reduced function post-injury

(2016) E.T. Fahy et al.   EXPERIMENTAL EYE RESEARCH

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy

(2016) N. Mazzaro et al.   JOURNAL OF NEUROSCIENCE

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

(2016) Yang Yang et al.   NATURE BIOTECHNOLOGY

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons

(2016) Jung-Hwan A Lim et al.   NATURE NEUROSCIENCE

Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma

(2016) Joseph Caprioli et al.   OPHTHALMOLOGY

TrkB Signaling in Retinal Glia Stimulates Neuroprotection after Optic Nerve Injury

(2015) Chikako Harada et al.   AMERICAN JOURNAL OF PATHOLOGY

An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse

(2015) Jonathan G. Crowston et al.   EXPERIMENTAL EYE RESEARCH

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

(2015) Sujeong Yang et al.   EXPERIMENTAL NEUROLOGY

Axonal transport declines with age in two distinct phases separated by a period of relative stability

(2015) Stefan Milde et al.   NEUROBIOLOGY OF AGING

Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice

(2015) Ji-Jie Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice

(2014) Odochi Ohia-Nwoko et al.   Molecular Neurodegeneration

Forced exercise protects the aged optic nerve against intraocular pressure injury

(2014) Vicki Chrysostomou et al.   NEUROBIOLOGY OF AGING

Glucose-Induced Temporary Visual Recovery in Primary Open-Angle Glaucoma

(2014) Robert J. Casson et al.   OPHTHALMOLOGY

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex

(2013) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

BDNF-dependent consolidation of fear memories in the perirhinal cortex

(2013) Brigitte Schulz-Klaus et al.   Frontiers in Behavioral Neuroscience

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Reduced Axonal Transport and Increased Excitotoxic Retinal Ganglion Cell Degeneration in Mice Transgenic for Human Mutant P301S Tau

(2012) Natalie D. Bull et al.   PLoS One

Self-amplifying autocrine actions of BDNF in axon development

(2011) P.-L. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration

(2011) Chikako Harada et al.   Nature Communications

Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats

(2010) Ana Seoane et al.   HIPPOCAMPUS

A semiautomated targeted sampling method to assess optic nerve axonal loss in a rat model of glaucoma

(2010) Nephtali Marina et al.   Nature Protocols

BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

(2010) Michael E. Hopkins et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

(2010) S. D. Crish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability

(2009) Laura Gasparini et al.   NEUROBIOLOGY OF AGING

Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation

(2009) E. R. Hollis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

I-TASSER: Fully automated protein structure prediction in CASP8

(2009) Yang Zhang   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Retinal tau pathology in human glaucomas

(2008) Neeru Gupta et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE