Recent Developments in Transition-Metal-Catalyzed Regioselective Functionalization of Imidazo[1, 2-a]pyridine

Imidazo[1,2-a]pyridine is an important nitrogen-containing heterocycle from biological as well as pharmaceutical point of view. In recent years, regioselective functionalization of C-H bond of imidazo[1,2-a]pyridine is extensively carried out using various transition metal-based catalysts. Alkenylation, arylation, dual dehydrogenative annulations, formylation, thiolation, aminomethylation, dicarbonylation, phosphonylation along with other significant reactions are the progress in the field of functionalization of imidazopyridine. Most of these functionalizations are done at the C-3 position of imidazo[1,2-a]pyridine scaffold and in addition to that development towards C-5 regioselectivity is also available. In this review, our aim is to present the recent advances for the functionalization of imidazo[1,2-a]pyridine employing transition metal catalysts under significant reaction conditions.

Automated summary

Imidazo[1,2-a]pyridine is an important nitrogen-containing heterocycle that has been extensively functionalized at the C-H bond using various transition metal catalysts in recent years. These functionalizations primarily occur at the C-3 position, with developments towards C-5 regioselectivity.