Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

Cristae undergo continuous cycles of membrane remodelling in a MICOS ‐dependent manner

(2020) Arun Kumar Kondadi et al.   EMBO REPORTS

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

(2020) Till Stephan et al.   EMBO JOURNAL

Glucose metabolism links astroglial mitochondria to cannabinoid effects

(2020) Daniel Jimenez-Blasco et al.   NATURE

Interrelation between ROS and Ca2+ in aging and age-related diseases

(2020) Corina T. Madreiter-Sokolowski et al.   Redox Biology

Supercomplex formation boosts respiration

(2020) Fabian Brave et al.   EMBO REPORTS

Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

(2020) Sabzali Javadov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent

(2019) Dane M Wolf et al.   EMBO JOURNAL

Live-cell STED nanoscopy of mitochondrial cristae

(2019) Till Stephan et al.   Scientific Reports

Who and how in the regulation of mitochondrial cristae shape and function

(2018) R. Quintana-Cabrera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

(2018) Rubén Quintana-Cabrera et al.   Nature Communications

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Integration of superoxide formation and cristae morphology for mitochondrial redox signaling

(2016) Lydie Plecitá-Hlavatá et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

(2016) Christina Glytsou et al.   Cell Reports

Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells

(2016) Ruchika Anand et al.   PLoS One

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning

(2014) L. Formentini et al.   EMBO JOURNAL

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

(2013) Evelina Maranzana et al.   ANTIOXIDANTS & REDOX SIGNALING

The ATP synthase: the understood, the uncertain and the unknown

(2013) John E. Walker   BIOCHEMICAL SOCIETY TRANSACTIONS

The function of the respiratory supercomplexes: The plasticity model

(2013) Rebeca Acin-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

(2013) Jaime Santo-Domingo et al.   EMBO JOURNAL

The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes

(2013) Anna Ghelli et al.   HUMAN MOLECULAR GENETICS

Human F1F0 ATP Synthase, Mitochondrial Ultrastructure and OXPHOS Impairment: A (Super-)Complex Matter?

(2013) Johann Habersetzer et al.   PLoS One

Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

(2013) B. Daum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor

(2012) Ruben Quintana-Cabrera et al.   Nature Communications

Cardiolipin Affects the Supramolecular Organization of ATP Synthase in Mitochondria

(2011) Devrim Acehan et al.   BIOPHYSICAL JOURNAL

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Sue/g

(2009) Regina Rabl et al.   JOURNAL OF CELL BIOLOGY

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial ATP synthase disorders: Molecular mechanisms and the quest for curative therapeutic approaches

(2008) Roza Kucharczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Mitochondrial Structure and Function by the F1Fo-ATPase Inhibitor Protein, IF1

(2008) Michelangelo Campanella et al.   Cell Metabolism

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

(2008) Robert W. Gilkerson et al.   JOURNAL OF CELL BIOLOGY

Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

(2008) Ryuji Yamaguchi et al.   MOLECULAR CELL