Review
Cardiac & Cardiovascular Systems
Ray W. Squires, Amanda R. Bonikowske
Summary: Heart transplantation is the preferred treatment for end-stage chronic heart failure. Although many patients experience improved functional ability after transplantation, they still face the challenges of acute rejection and other comorbidities. Exercise training, recommended before and after transplantation, can improve exercise capacity and skeletal muscle strength without altering immunosuppression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Catherine Giuliano, Don Vicendese, Sara Vogrin, Rebecca Lane, Andrea Driscoll, Diem Dinh, Katie Palmer, Itamar Levinger, Christopher Neil
Summary: This study investigated the rate and factors associated with referral to cardiac rehabilitation (CR) among patients hospitalized with heart failure (HF). The results showed a low rate of referral, particularly among females, older patients, and those with chronic obstructive pulmonary disease or anemia. Future studies should focus on improving referral processes and implementing strategies to increase referrals to CR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Rod S. Taylor, Hasnain M. Dalal, Ann-Dorthe Zwisler
Summary: Cardiac rehabilitation is often overlooked in the treatment of heart failure. This review provides an update on the evidence, guidelines, and status of cardiac rehabilitation for heart failure patients. It argues that exercise-based rehabilitation is a crucial aspect of heart failure management, alongside medication and medical devices, as it improves patient outcomes, including their quality of life. To improve access and participation, healthcare services should offer heart failure patients a range of evidence-based rehabilitation options, including home-based programs with digital technology and traditional center-based programs, based on disease stage and patient preference.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Gregg C. Fonarow, Lee R. Goldberg, Maya Guglin, Richard A. Josephson, Daniel E. Forman, Grace Lin, JoAnn Lindenfeld, Chris O'Connor, Gurusher Panjrath, Ileana L. Pina, Tina Shah, Shashank S. Sinha, Eugene Wolfel
Summary: Cardiac rehabilitation, which includes exercise training, risk factor modification, and outcomes assessment, is safe and beneficial for patients with HF. Despite its effectiveness and cost-efficiency, it is currently underused and should be prioritized as part of standard care for HF patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Rehabilitation
Yoichiro Aoyagi, Etsuko Mori, Hideki Ishii, Yuji Kono, Ayako Sato, Yuki Okochi, Reisuke Funahashi, Hitoshi Kagaya
Summary: This study compared the effects of cardiac rehabilitation therapies performed in wards and rehabilitation units during the COVID-19 pandemic. The results showed that patients receiving ward-based rehabilitation had lower walking distance and speed at discharge compared to those admitted before the outbreak, and they also had shorter exercise time.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kyle Gobeil, Kevin White, Anusha Bhat, Heidi Szalai, Tara C. Lagu, Quinn R. Pack
Summary: The study found that utilization of cardiac rehabilitation in Takotsubo cardiomyopathy patients is inconsistent, despite the potential benefits of exercise for improving exercise capacity.
Review
Cardiac & Cardiovascular Systems
Heather L. Wheat, Savitri Fedson, Biykem Bozkurt, Richard A. Josephson
Summary: Exercise intolerance is common in heart failure patients, and cardiac rehabilitation has shown significant benefits in improving mortality and quality of life. However, the benefits of exercise therapy may vary depending on the underlying disease phenotype.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Rehabilitation
Matthew R. Ely, Grant D. Schleifer, Tamanna K. Singh, Aaron L. Baggish, J. Andrew Taylor
Summary: This study aimed to investigate the effects of different exercise training modes on cardiac atrophy and loss of function in patients with acute spinal cord injury (SCI). The results showed that neither upper-body exercise alone nor a combination of upper-body exercise with lower-body electrical stimulation had a significant impact on cardiac structure and function. This suggests that current rehabilitative aerobic exercise practices are not effective in preventing cardiac decline in individuals with SCI and further interventions are needed.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine R. Collins, Gordon Reeves, Nancy Houston J. Miller, David M. Whellan, Christopher H. O'Connor, Bess W. Marcus, Dalane E. Kitzman, William Kraus, HF ACTION Invest
Summary: The purpose of this analysis was to identify baseline clinical and demographic characteristics predicting exercise training adherence in the HF-ACTION study cohort. The results showed that younger age, lower income, more severe mitral regurgitation, shorter 6-min walk test distance, lower exercise capacity, and Black or African American race were associated with poorer exercise intervention adherence. However, these characteristics had very limited predictive contribution to adherence.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Marine Kirsch, Moatemri Feriel, Lamar Tanguy Aurelia, Kovalska Oksana, Blanchard Jean Christophe, Ledru Francois, Cristofini Pascal, Damien Vitiello, Iliou Marie-Christine
Summary: This study aimed to evaluate the impact of a 4-week cardiac rehabilitation program on cardiopulmonary exercise testing and echocardiography parameters in chronic heart failure patients. The results showed that the training program significantly improved peak oxygen consumption, left ventricular outflow tract velocity time integral, circulatory power, and ventilatory power, while decreasing the VE/VCO2 slope. Responders to training had higher left ventricle contractile reserve compared to non-responders.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Physiology
Chen Guo, Meng-Jie Chen, Jin-Rui Zhao, Rui-Yun Wu, Yue Zhang, Qiang-Qiang Li, Hong Zhao, Jia-Hao Dou, Shou-Fang Song, Jin Wei
Summary: This study investigated the cardioprotective effects of different aerobic exercises on chronic heart failure with different etiologies and the role of mitophagy. The results showed that moderate-intensity continuous training (MICT) may be the best exercise modality for improving cardiac structure and function in ischemic heart failure, while both MICT and high-intensity interval training (HIIT) were suitable for pressure-overload heart failure. Additionally, various mitophagy pathways, especially parkin-dependent pathways, were found to be involved in the protective effects of exercise on heart failure.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Vandana Sachdev, Kavita Sharma, Steven J. Keteyian, Charina F. Alcain, Patrice Desvigne-Nickens, Jerome L. Fleg, Viorel G. Florea, Barry A. Franklin, Maya Guglin, Martin Halle, Eric S. Leifer, Gurusher Panjrath, Emily A. Tinsley, Renee P. Wong, Dalane W. Kitzman
Summary: HFpEF is a common form of heart failure with increasing prevalence and worsening outcomes. Pharmacological interventions have shown limited efficacy, while exercise-based interventions consistently improve symptoms and quality of life. This may be attributed to the pleiotropic effects of exercise, which positively influence the various abnormalities contributing to exercise intolerance in HFpEF. This article critically examines the effects of exercise-based therapies, compares them with other cardiovascular conditions, and highlights gaps in implementation for future research.
Article
Cardiac & Cardiovascular Systems
Barry Burstein, Vidhu Anand, Bradley Ternus, Meir Tabi, Nandan S. Anavekar, Barry A. Borlaug, Gregory W. Barsness, Garvan C. Kane, Jae K. Oh, Jacob C. Jentzer
Summary: The study found that echocardiographic CPO was inversely associated with hospital mortality in unselected CICU patients, particularly among patients with increased lactate and vasopressor requirements.
AMERICAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Andrea Passantino, Laura Adelaide Dalla Vecchia, Ugo Corra, Simonetta Scalvini, Massimo Pistono, Maurizio Bussotti, Fabiana Isabella Gambarin, Domenico Scrutinio, Maria Teresa La Rovere
Summary: Cardiac rehabilitation (CR) is a comprehensive program that includes multiple components and can lead to significant physical and psychological benefits. Exercise-based CR for heart failure patients is a recommended treatment that should be personalized and optimized for each individual.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Arlana G. Taylor, Andrew I. Ignaszewski, Shannon S. D. Bredin, John S. Hill, Erin M. Shellington, Darren E. R. Warburton
Summary: This study aimed to evaluate the acute inflammatory response in patients with chronic heart failure (CHF) following steady state (SS) or high intensity interval training (HIIT). The results showed that a single bout of HIIT or SS did not result in excessive inflammatory activation in CHF patients, and both types of exercise had similar effects on inflammatory markers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jennifer B. Green, Peter Merrill, Yuliya Lokhnygina, Robert J. Mentz, Joakim Alfredsson, Rury R. Holman, EXSCEL Study Grp
Summary: This study aimed to examine sex differences in patients with type 2 diabetes (T2D) and compared the characteristics and outcomes between those treated with exenatide and placebo. The results showed that female patients had differences in age, duration of diabetes, and coronary artery disease compared to male patients, but had worse metabolic risk profiles and lower use of cardioprotective medications. Despite these factors, women had significantly lower rates of cardiovascular events.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Robert J. Mentz, Kevin J. Anstrom, Eric L. Eisenstein, Shelly Sapp, Stephen J. Greene, Shelby Morgan, Jeffrey M. Testani, Amanda H. Harrington, Vandana Sachdev, Fassil Ketema, Dong-Yun Kim, Patrice Desvigne-Nickens, Bertram Pitt, Eric J. Velazquez
Summary: A randomized trial found that torsemide did not result in a significant difference in all-cause mortality compared with furosemide among patients hospitalized for heart failure. However, the interpretation of these findings is limited by loss to follow-up and participant crossover and nonadherence.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Vanessa Blumer, Anuradha Lala, Robert J. Mentz
JOURNAL OF CARDIAC FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Husam M. M. Salah, Gianluigi Savarese, Giuseppe M. C. Rosano, Andrew P. P. Ambrosy, Robert J. J. Mentz, Marat Fudim
Summary: We conducted a meta-analysis of existing randomized controlled trials to evaluate the effect of intravenous iron infusion on cardiovascular outcomes in heart failure patients. The results showed that intravenous iron significantly reduced the risk of first hospitalization for heart failure and cardiovascular mortality, as well as the risk of total hospitalizations for heart failure. However, it had no significant impact on all-cause mortality or cardiovascular mortality alone.
Article
Engineering, Biomedical
Joseph B. Lerman, Derek D. Cyr, Karen Chiswell, Rachel S. Tobin, Marat Fudim, Sean D. Pokorney, Robert J. Mentz, Marc D. Samsky
Letter
Medicine, General & Internal
Robert J. Mentz, Tracy A. DeWald, Eric J. Velazquez
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Huzaifa Ahmad Cheema, Saleha Azeem, Abdullah Ejaz, Faiza Khan, Anza Muhammad, Abia Shahid, Abdulqadir J. Nashwan, Muhammad Haisum Maqsood, Sourbha S. Dani, Robert J. Mentz, Marat Fudim, Gregg C. Fonarow
CLINICAL CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Tariq Jamal Siddiqi, Ahmed Mustafa Rashid, Syed Sarmad Javaid, Ahmed Kamal Siddiqi, Muhammad Shariq Usman, Oliver Hervir, Daisuke Kamimura, Carl J. Lavie, Robert J. Mentz, Javed Butler, Michael E. Hall
Summary: High-intensity interval training (HIIT) significantly improved peak oxygen consumption (peak VO2) in patients with HFpEF compared to moderate continuous training (MCT). However, there were no significant changes in left atrial volume index (LAVI), respiratory exchange ratio (RER), and ventilatory efficiency (VE/CO2 slope) between HIIT and MCT in patients with HFpEF.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Piotr Ponikowski, Robert J. Mentz, Adrian F. Hernandez, Javed Butler, Muhammad Shahzeb Khan, Dirk J. van Veldhuisen, Bernard Roubert, Nicole Blackman, Tim Friede, Ewa A. Jankowska, Stefan D. Anker
Summary: This meta-analysis of intravenous ferric carboxymaltose therapy for iron-deficient heart failure patients found a significantly reduced risk of hospitalizations for HF and cardiovascular causes, with no apparent effect on mortality.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Anuradha Lala, Robert J. Mentz
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Anuradha Lala, Anekwe Onwuanyi, Alanna A. Morris, Robert J. Mentz
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Josephine Harrington, Stephen Greene, Jie-Lena Sun, Brooke Alhanti, Marat Fudim, Michael Felker, Javed Butler, Randall Starling, Christopher O'Connor, Adrian Hernandez, Robert Mentz
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vanessa Blumer, Olivia Gilbert, Robert Mentz, Haiying Chen, Alain Bertoni, David Whellan, Dalane Kitzman, Pamela Duncan, Gordon Reeves, Shelby D. Reed, Bharathi Upadhya, Christopher O'Connor, Amy Pastva
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathy Z. Dai, Eric B. Laber, Robert J. Mentz, Huaxuan Chen, Chetna Malhotra
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Josephine Harrington, Maggie Nguyen, Jennifer Green, Naveed Sattar, Neha J. Pagidipati, Adrian F. Hernandez, Robert John Mentz, Harald Sourij, Rury R. Holman, Svati Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)