Review
Gastroenterology & Hepatology
Tarik Asselah, David Durantel, Eric Pasmant, George Lau, Raymond F. Schinazi
Summary: COVID-19 started in Wuhan in 2019 and has become a global pandemic. The virus responsible, SARS-CoV-2, shares a high sequence identity with bat- and pangolin-derived coronaviruses. Risk factors for SARS-CoV-2 infection include age, obesity, diabetes, and hypertension.
JOURNAL OF HEPATOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hailei Su, Feng Zhou, Ziru Huang, Xiaohua Ma, Kathiresan Natarajan, Minchuan Zhang, Yong Huang, Haibin Su
Summary: This article summarizes and analyzes recent studies on the molecular mechanisms of promising antiviral drugs for COVID-19, focusing on viral targets such as spike glycoprotein and host proteases, aiming to inspire new ideas for drug design and optimization in the future.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Nataly Kacherovsky, Lucy F. Yang, Ha Dang, Emmeline L. Cheng, Ian I. Cardle, Alexandra C. Walls, Matthew McCallum, Drew L. Sellers, Frank DiMaio, Stephen J. Salipante, Davide Corti, David Veesler, Suzie H. Pun
Summary: The COVID-19 pandemic has caused devastation to families, healthcare, economies, and societies globally. Molecular recognition agents that bind to specific viral proteins are crucial for rapid diagnostics and targeted therapeutics. This work demonstrates the selection of novel DNA aptamers that bind to the SARS-CoV-2 spike glycoprotein with high specificity and affinity, making them promising tools for COVID-19 diagnostics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Virology
Yan Li, Jiaxin Yang, Siyu Shen, Wei Wang, Nian Liu, Haoran Guo, Wei Wei
Summary: The viral proteins encoded by SARS-CoV-2 can suppress the activity of L1 retrotransposons in host cells. These viral inhibitors modulate the transposition activity of L1 through a complex network, affecting host genome stability and antiviral immune activation.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Pharmacology & Pharmacy
Yuefei Zhu, Jia Li, Zhiqing Pang
Summary: The global outbreak of COVID-19 has posed a serious threat to humanity, requiring a more in-depth understanding of the epidemic and the development of rational containment strategies. While there is currently no specific antiviral therapy, rapid detection technology and promising treatment methods have been helpful.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Essam H. Ibrahim, Hamed A. Ghramh, Mona Kilany
Summary: The study aimed to develop a new rapid and cost-effective method for detecting anti-SARS-CoV-2 IgG/IgM Abs, which showed simplicity, reproducibility, and accuracy with results obtainable in less than 5 minutes. It is anticipated to be widely used for point-of-care testing before resorting to costly nucleic acid assays.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ridhima Kaul, Pradipta Paul, Sanjay Kumar, Dietrich Buesselberg, Vivek Dhar Dwivedi, Ali Chaari
Summary: This review summarizes the activities and structure-activity relationships of flavonoids in combating SARS-CoV-2 from in vitro studies to clinical research. The study found that flavonoids such as quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid show promising activities against SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Himanshu G. Toor, Devjani I. Banerjee, Soumya Lipsa Rath, Siddhi A. Darji
Summary: The global COVID-19 pandemic has caused over a million deaths, leading to intense research on potential therapeutic strategies targeting the spike glycoprotein of SARS-CoV-2. Multiple known drug candidates have shown significant interactions with the virus, indicating potential for designing novel combinatorial therapy formulations.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Choon Kim, Kiran Mahasenan, Atul Bhardwaj, Olaf Wiest, Mayland Chang, Shahriar Mobashery
Summary: The text discusses the importance of proteins encoded by SARS-CoV-2 in the replication of the virus, and the process of cloning, expression, production, and purification of these proteins for potential discovery of anti-COVID-19 pharmaceuticals. Researchers have successfully identified small-molecule binders as molecular template hits through their work on these proteins, which could serve as a basis for further optimization.
Review
Biochemistry & Molecular Biology
Annoor Awadasseid, Yanling Wu, Yoshimasa Tanaka, Wen Zhang
Summary: COVID-19 caused by SARS-CoV-2 has become a global pandemic, with China being at the forefront of vaccine development. The last inactivated vaccine international clinical trial has been launched in the UAE, showing promising progress in creating efficacious and safe vaccines against SARS-CoV-2.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Perez-Pena, Stefano Pieraccini, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Daniele Passarella, Clelia Giannini
Summary: SARS-CoV-2 M-pro is a significant enzyme in the replication and infectivity of SARS-CoV-2. We synthesized and evaluated MPD112, a novel inhibitor of SARS-CoV-2 M-pro, which displayed inhibition activity at a low micromolar level in vitro. The compound showed selectivity for M-pro and demonstrated good tolerability and biological activity in human cells.
Article
Immunology
Nandan Gautam, Shyam Madathil, Natascia Tahani, Shaun Bolton, Dhruv Parekh, James Stockley, Shraddha Goyal, Hannah Qureshi, Sadhika Yasmin, Brendan G. Cooper, Jennifer Short, Tarekegn Geberhiwot
Summary: A study found that a significant proportion of severely ill COVID-19 patients still experience symptoms such as breathlessness, fatigue, pain, reduced mobility, depression, and decreased quality of life 4-7 months after disease onset, with symptomatic patients having more residual chest radiographic and LFT abnormalities.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Zhenyu Zhao, Kefeng Lu, Binli Mao, Shi Liu, Mirko Trilling, Ailong Huang, Mengji Lu, Yong Lin
Summary: SARS-CoV-2 is the third highly pathogenic emerging human coronavirus, causing the COVID-19 pandemic globally. Studies show that coronavirus infections may be related to autophagy, which could even promote viral infection and replication. It remains unclear how coronavirus infections induce autophagy and whether the autophagic machinery is essential for viral propagation.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Microbiology
Yu-An Kung, Kuo-Ming Lee, Huan-Jung Chiang, Sheng-Yu Huang, Chung-Jung Wu, Shin-Ru Shih
Summary: This review discusses the molecular mechanisms of SARS-CoV-2 and related coronaviruses, with a focus on host factors or pathways identified through genome-wide CRISPR screening that can be targeted for the development of effective antiviral agents.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2022)
Article
Medicine, Research & Experimental
Lin Wang, Junhu Zhou, Qixue Wang, Yunfei Wang, Chunsheng Kang
Summary: This study proposes a potential anti-SARS-CoV-2 strategy based on the CRISPR-Cas13a system, identifying a specific RNA segment of the spike protein and designing an efficient crRNA sequence for cleavage. It provides a rapid design pipeline for an antiviral tool against SARS-CoV-2 and introduces a novel approach for anti-virus study.