期刊
FRONTIERS IN PHYSIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.631500
关键词
spinal cord injury; blood vessel; nerve regeneration; therapeutic interventions; angiogenesis
类别
资金
- National Major Project of Research and Development [2017YFA0104701]
- Jiangsu Association of Science and Technology Youth Science and Technology Talents Enrollment Project
Traumatic spinal cord injury (SCI) leads to a series of complex pathological reactions, affecting the local microenvironment. Although endogenous angiogenesis is triggered, the new vessels often do not function normally. Many blood vessel interventions have been applied in SCI treatment.
Traumatic spinal cord injury (SCI) is a complex pathological process. The initial mechanical damage is followed by a progressive secondary injury cascade. The injury ruptures the local microvasculature and disturbs blood-spinal cord barriers, exacerbating inflammation and tissue damage. Although endogenous angiogenesis is triggered, the new vessels are insufficient and often fail to function normally. Numerous blood vessel interventions, such as proangiogenic factor administration, gene modulation, cell transplantation, biomaterial implantation, and physical stimulation, have been applied as SCI treatments. Here, we briefly describe alterations and effects of the vascular system on local microenvironments after SCI. Therapies targeted at revascularization for SCI are also summarized.
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