Article
Biochemical Research Methods
Isabel Barranco, Christian M. Sanchez-Lopez, Diego Bucci, Alberto Alvarez-Barrientos, Heriberto Rodriguez-Martinez, Antonio Marcilla, Jordi Roca
Summary: This study aims to define and analyze subsets of extracellular vesicles (EVs) in pig seminal plasma. Using ultrafiltration and size exclusion chromatography, EV subsets were isolated and their proteomic profiles were decoded. The results showed that the subsets, S-EVs and L-EVs, have different sources and biological functions, with S-EVs involved in modulating the immune environment of the female reproductive tract and sperm-oocyte interaction, and L-EVs involved in sperm physiological processes.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Review
Biochemistry & Molecular Biology
Madalina Gabriela Barbu, Dana Claudia Thompson, Nicolae Suciu, Silviu Cristian Voinea, Dragos Cretoiu, Dragos Valentin Predescu
Summary: MicroRNAs play a significant role in male infertility, with their concentration in semen being linked to specific reproductive dysfunctions. Aberrant expression of certain microRNAs has been associated with male reproductive disorders. Additionally, idiopathic male infertility is connected to single nucleotide polymorphisms in microRNA binding sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Luiz Cordeiro, Hsiu-Lien Herbie Lin, Anais Vitorino Carvalho, Isabelle Grasseau, Rustem Uzbekov, Elisabeth Blesbois
Summary: This study successfully demonstrated the presence of extracellular vesicles in chicken seminal plasma, with differential size, protein markers, and putative incorporation capacity according to male fertility status. Extracellular vesicles enriched seminal fractions from fertile males showed a higher capacity to be incorporated into fertile sperm and impacted sperm viability and motility.
Article
Multidisciplinary Sciences
Masood Abu-Halima, Lea Simone Becker, Mohammad A. Al Smadi, Lea Sophie Kunz, Laura Groeger, Eckart Meese
Summary: This study investigated the role of miRNAs and SPAG7 in male infertility. It found that miR-424 and miR-497 were upregulated in oligoasthenozoospermic men, while SPAG7 expression was downregulated. These findings suggest a potential regulatory role of miR-424 and SPAG7 in the pathogenesis of oligoasthenozoospermia.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Maria-Anna Kyrgiafini, Zissis Mamuris
Summary: This systematic review investigates the differential expression of circRNAs in male infertility and their potential as candidate biomarkers. It was found that many circRNAs are deregulated in male infertility and their interactions with miRNAs play a crucial role in cellular processes and pathways. CircRNAs could also be used as biomarkers for screening patients before sperm retrieval, but there is a knowledge gap regarding their role in other subtypes of male infertility.
Article
Reproductive Biology
Maira Bianchi Rodrigues Alves, Rubens Paes de Arruda, Leonardo Batissaco, Laura Nataly Garcia-Oliveros, Vitor Hugo Guilger Gonzaga, Vinicius Jose Moreira Nogueira, Flavia dos Santos Almeida, Samara Cristine Costa Pinto, Gabriella Mamede Andrade, Felipe Perecin, Juliano Coelho da Silveira, Eneiva Carla Carvalho Celeghini
Summary: The study found that scrotal heat stress affects the levels of sperm miRNA and seminal plasma sEVs, leading to changes in sperm morphology and function, causing an increase in sperm oxidative stress and alterations in miRNA levels. This suggests that scrotal heat stress may impact testicular and epididymis functions, ultimately affecting sperm formation and maturation.
Review
Medicine, General & Internal
Michal Jeseta, Anna Pospisilova, Lenka Mekinova, Katerina Franzova, Pavel Ventruba, Eva Lousova, Bartosz Kempisty, Tomas Ozdian, Jana Zakova, Igor Crha
Summary: The compounds in seminal plasma have potential as biomarkers for male fertility and can be used for diagnosing different types of azoospermia. Distinguishing between obstructive and non-obstructive azoospermia is important for effective treatment. Proteins in seminal plasma, particularly testicular and epididymal proteins, can serve as biomarkers for diagnosing azoospermia. Combining multiple biomarkers, such as TEX101 and ECM1 or TEX101 and SPAG1, can improve diagnostic accuracy.
Article
Health Care Sciences & Services
Carmine Bruno, Umberto Basile, Edoardo Vergani, Cecilia Napodano, Alessandro Oliva, Francesca Gulli, Elisabetta Meucci, Andrea Silvestrini, Patrick Orlando, Sonia Silvestri, Luca Tiano, Antonio Mancini
Summary: FLCs may play an important role in male infertility, especially in varicocele. The levels of CoQ10 and Total Antioxidant Capacity (TAC) in semen may be correlated with FLCs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Andrology
Anne-Sophie Neyroud, Regina Chiechio, Marina Yefimova, Maria Jose Lo Faro, Nathalie Dejucq-Rainsford, Sylvie Jaillard, Pascale Even-Hernandez, Valerie Marchi, Celia Ravel
Summary: Extracellular Vesicles (EVs) are membrane-limited particles secreted by healthy and cancerous cells, containing proteins, lipids, metabolites and nucleic acids, mediating various biological functions. In the male genital tract, three subtypes of EV have been described, differing in secretion location such as the testis, prostate or epididymis. EVs can fuse together, deliver information to recipient cells like spermatozoa, and potentially modulate transmitted information to the next generation through epigenetic changes.
BASIC AND CLINICAL ANDROLOGY
(2021)
Review
Medicine, General & Internal
Angel Earle, Madison Bessonny, Josh Benito, Kun Huang, Hannah Parker, Emily Tyler, Brittany Crawford, Nabeeha Khan, Bridget Armstrong, Alexis Stamatikos, Sudha Garimella, Alyssa Clay-Gilmour
Summary: The early detection of chronic kidney disease is crucial, and there is growing interest in finding new biomarkers. Currently, there is no single effective biomarker, but there is evidence supporting the use of urinary exosomal microRNAs as biomarkers for kidney fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yentel Mateo-Otero, Marc Yeste, Jordi Roca, Marc Llavanera, Diego Bucci, Giovanna Galeati, Marcella Spinaci, Isabel Barranco
Summary: Seminal plasma extracellular vesicles (EVs) can modulate ovary function, but do not affect oocyte maturation. Only large EVs have an effect on cumulus cells function.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Haiming Cao, Zi Wan, Fei Wang, Ziyin Liu, Xiaofeng Li, Jianquan Hou
Summary: The study identified 27 shared genes associated with spermatogenesis through reanalyzing gene expression databases and validation datasets. Among these genes, KIF2C and TEKT2 were found to be down-regulated in spermatogenesis and validated in multiple datasets. The study also established a TF-miRNA-target gene network, suggesting that KIF2C may play a role in spermatogenesis through interactions with miRNAs and TFs.
Article
Biochemistry & Molecular Biology
A. S. Vickram, K. Anbarasu, G. Gulothungan, S. Thanigaivel, R. Nanmaran, Jeyanthi Palanivelu
Summary: This study characterized prostasomes using biochemical, molecular, and in silico methods, and identified a novel protein biomarker Clusterin for the diagnosis and prognosis of male infertility.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Developmental Biology
C. F. Burgos, R. Cikutovic, M. Alarcon
Summary: In this review, the role of miRNAs in male infertility pathology was analyzed, with a focus on identifying relevant biomarkers and potential therapeutic targets. By selecting and examining miRNAs with altered expressions in testis tissue, researchers were able to identify signaling pathways and protein interactions associated with male infertility, confirming the PI3K-Akt signaling pathway as the most affected and relevant pathway.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
A. S. Vickram, K. Anbarasu, G. Gulothungan, S. Thanigaivel, R. Nanmaran, Jeyanthi Palanivelu
Summary: This study characterized prostasomes using biochemical, molecular, and in silico methods, and identified a novel protein biomarker Clusterin for the diagnosis and prognosis of male infertility.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Fisheries
S. Thanigaivel, John Thomas, A. S. Vickram, G. Gulothungan, R. Nanmaran, D. Jenila Rani
Summary: The antioxidant and antibacterial properties of aqueous and ethanolic extracts of Chaetomorpha linum were tested against Pseudomonas aeruginosa infection. The ethanolic extract showed effectiveness in controlling the bacterial infection, and was found to be non-toxic to fish.
JOURNAL OF APPLIED AQUACULTURE
(2023)
Article
Automation & Control Systems
D. Palanikkumar, Kamal Upreti, S. Venkatraman, J. Roselin Suganthi, Sridharan Kannan, S. Srinivasan
Summary: The selection of mining method for underground minerals extraction is a crucial task for mining engineers, involving various geological characteristics and deposit characteristics. Currently, only fuzzy logic approach has been used for selecting a mining method for underground metal mines.
INTELLIGENT AUTOMATION AND SOFT COMPUTING
(2022)
Article
Automation & Control Systems
G. Chamundeeswari, S. Srinivasan, S. Prasanna Bharathi
Summary: This paper presents an optimal technique for monitoring environmental and crop changes using remote sensing data. The proposed method includes image enhancement, optimization of greenery regions, dimension reduction, and classification to improve crop classification and yield assessment accuracy.
INTELLIGENT AUTOMATION AND SOFT COMPUTING
(2022)
Article
Computer Science, Hardware & Architecture
K. S. Archana, S. Srinivasan, S. Prasanna Bharathi, R. Balamurugan, T. N. Prabakar, A. Sagai Francis Britto
Summary: Rice is a major food crop in India and increasing its production is crucial to meet the demands of a growing population. This study proposes a novel method to identify rice plant diseases through segmentation, feature extraction, and image classification. The results show better accuracy compared to other methods.
JOURNAL OF SUPERCOMPUTING
(2022)
Review
Biotechnology & Applied Microbiology
Arunkumar Priya, Gururajan Anusha, Sundaram Thanigaivel, Alagar Karthick, Vinayagam Mohanavel, Palanivel Velmurugan, Balamuralikrishnan Balasubramanian, Manickam Ravichandran, Hesam Kamyab, Irina Mikhailovna Kirpichnikova, Shreeshivadasan Chelliapan
Summary: Public sewage treatment plants serve as a common pathway for microplastics to enter local surroundings, posing a threat to marine wildlife and humans. The behavior and mechanisms of microplastics in wastewater treatment procedures are still unknown.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Review
Environmental Sciences
Nibedita Dey, C. Kamatchi, A. S. Vickram, K. Anbarasu, S. Thanigaivel, Jeyanthi Palanivelu, Arivalagan Pugazhendhi, Vinoth Kumar Ponnusamy
Summary: The changes in lifestyle and living conditions have affected both humans and microorganisms, leading to the issue of multi-drug resistance. The use of nanotechnology offers hope in overcoming resistance by providing a synergistic effect with antibiotics through nanoparticles. By targeting efflux systems, it might be possible to make previously resistant medications effective again.
ENVIRONMENTAL RESEARCH
(2022)
Article
Energy & Fuels
Sundaram Thanigaivel, Sundaram Vickram, Nibedita Dey, Govindarajan Gulothungan, Ramasamy Subbaiya, Muthusamy Govarthanan, Natchimuthu Karmegam, Woong Kim
Summary: Microalgal-based biorefinery systems offer advantages in meeting the rising demand for biofuel, food, and feed, as well as pharmaceuticals. However, there are challenges in terms of sustainability and cost-effectiveness.
Review
Energy & Fuels
Nibedita Dey, Sundaram Vickram, Sundaram Thanigaivel, Ramasamy Subbaiya, Woong Kim, Natchimuthu Karmegam, Muthusamy Govarthanan
Summary: This article highlights the progress in the transformation of lignocellulosic biomass derivatives for applications in the food, paper, and biofuel industries.
Review
Biochemistry & Molecular Biology
Sundaram Vickram, Karunakaran Rohini, Krishnan Anbarasu, Palanivelu Jeyanthi, Sundaram Thanigaivel, Praveen Kumar Issac, Jesu Arockiaraj
Summary: Male infertility affects approximately 1/10 couples worldwide, with a higher prevalence in developed countries. Semenogelin, a protein found in seminal vesicle secretions, plays a crucial role in fertilization by contributing to sperm motility and capacitation. This review highlights the significant functions of semenogelin and its potential for advanced proteomics research on molecular mechanisms in fertilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Anbarasu Krishnan, Duraisami Dhamodharan, Thanigaivel Sundaram, Vickram Sundaram, Hun-Soo Byun
Summary: In this computational study, virtual screening was conducted on human LMTK3 to identify potential anticancer compounds for the treatment of ER alpha positive breast cancer. The results revealed that the compound NCI26194, screened from the NCI database, has the potential to act as a key drug molecule for this type of breast cancer.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Environmental Sciences
Saranya Narayanasamy, Vickram Sundaram, Thanigaivel Sundaram, Dai-Viet N. Vo
Summary: This review article discusses the potential of plant-based biosorbents in removing Cr(VI) from water sources. The removal process can be achieved through adsorption and adsorption-coupled reduction mechanisms, and the biosorbents exhibit high adsorption capacities and regeneration potential.
ENVIRONMENTAL RESEARCH
(2022)
Article
Automation & Control Systems
T. S. Balaji, S. Srinivasan
Summary: This study develops a revolutionary SDN controller-based real-time traffic flow forecasting technique for clustered VANETs, combining the scalability, flexibility, and adaptability of SDN controllers with deep learning models. A novel arithmetic optimization-based clustering technique is also proposed. Experimental results demonstrate the superior performance of the suggested method in traffic management.
INTELLIGENT AUTOMATION AND SOFT COMPUTING
(2023)
Article
Automation & Control Systems
Adepu Shravan Kumar, S. Srinivasan
Summary: The Industrial Internet of Things (IIoT) is rapidly evolving and image data from terminal devices and IoT nodes are linked to user's private data. The use of image sensors as an automation tool for IIoT is increasing. However, a major issue is reducing data quantity and bandwidth while maintaining image quality. Image compression in the sensor expedites data transfer and reduces bandwidth use. Image encryption provides a safe method for protecting picture transformation and storage in IIoT systems. This research proposes an AHBO-LBGCCE approach that combines LBG-enabled codebook creation and encryption for IIoT. Experimental investigation confirms the effectiveness of the proposed algorithm.
INTELLIGENT AUTOMATION AND SOFT COMPUTING
(2023)
Article
Computer Science, Information Systems
Ashit Kumar Dutta, S. Srinivasan, Bobbili Prasada Rao, B. Hemalatha, Irina Pustokhina, Denis A. Pustokhin, Gyanendra Prasad Joshi
Summary: In this paper, an Ensemble of Metaheuristic Optimization based QoS aware Clustering with Multihop Routing (EMOQoSCMR) Protocol is proposed for enhancing the sensor data transmission in wireless sensor networks (WSN) assisted by Internet of Things (IoT). The EMO-QoSCMR protocol utilizes crossentropy rain optimization algorithm based clustering (CEROAC) technique and oppositional chaos game optimization based routing (OCGOR) technique to achieve QoS parameters such as energy, throughput, delay, and lifetime.
CMC-COMPUTERS MATERIALS & CONTINUA
(2022)
