Article
Multidisciplinary Sciences
Samuel Druzak, Elizabeth Iffrig, Blaine R. Roberts, Tiantian Zhang, Kirby S. Fibben, Yumiko Sakurai, Hans P. Verkerke, Christina A. Rostad, Ann Chahroudi, Frank Schneider, Andrew Kam Ho Wong, Anne M. Roberts, Joshua D. Chandler, Susan O. Kim, Mario Mosunjac, Marina Mosunjac, Rachel Geller, Igor Albizua, Sean R. Stowell, Connie M. Arthur, Evan J. Anderson, Anna A. Ivanova, Jun Ahn, Xueyun Liu, Kristal Maner-Smith, Thomas Bowen, Mirko Paiardini, Steve E. Bosinger, John D. Roback, Deanna A. Kulpa, Guido Silvestri, Wilbur A. Lam, Eric A. Ortlund, Cheryl L. Maier
Summary: In this study, the authors investigate the mechanism of endothelial damage in critical illness associated with SARS-CoV-2 using a multiomics and microfluidics-based approach. They identify alterations in fluid shear stress-responsive pathways and demonstrate how plasma from critically ill COVID-19 patients induces red blood cell aggregation and damages the microvascular glycocalyx. They also find differences in pathogenesis between adult and pediatric COVID-19 patients.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim
Summary: This nationwide population-based study aimed to determine whether COVID-19 hospitalization was associated with incident cardiovascular outcomes. The study found that hospitalized patients with COVID-19 were not at an increased risk of cardiovascular outcomes compared to patients with non-COVID-19 pneumonia.
Review
Cardiac & Cardiovascular Systems
Somasundaram Raghavan, R. Gayathri, Sudhakar Kancharla, Prachetha Kolli, J. Ranjitha, Vijayalakshmi Shankar
Summary: The SARS-CoV-2 virus not only primarily infects the lungs and respiratory system, but also affects the cardiovascular system and coagulation mechanisms, leading to various cardiovascular diseases. The virus enters endothelial cells through ACE2 receptors, thereby impacting the cardiovascular system.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Tzu-Chen Lo, Yu-Yen Chen
Summary: This study aimed to better understand the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following COVID-19. Research found that MIS-C associated with COVID-19 shares features similar to Kawasaki disease and may be related to post-infective immune dysregulation. Further studies are needed to elucidate the underlying pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu
Summary: The cytokine storm induced by SARS-CoV-2 is a major pathological feature of COVID-19, with HIF-1α and pro-inflammatory cytokines playing key roles in infection and inflammatory responses. The production of HIF-1α, inflammatory responses, and high mortalities in elderly patients indicate its crucial role in exacerbating COVID-19.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Virology
Vishakh C. Keri, Amit Hooda, Parul Kodan, R. L. Brunda, Pankaj Jorwal, Naveet Wig
Summary: Covid-19 can lead to cardiovascular complications, especially in elderly patients with prior cardiac diseases. Challenges in management include overlapping symptoms, drug effects on ECG and arrhythmias, drug interactions, and the need to identify patients requiring urgent care.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Sinem Nihal Esatoglu, Koray Tascilar, Hakan Babaoglu, Cemal Bes, Berna Yurttas, Servet Akar, Ozlem Pehlivan, Cansu Akleylek, Duygu Tecer, Emire Seyahi, Tuba Yuce-Inel, Nilufer Alpay-Kanitez, Erdal Bodakci, Emre Tekgoz, Seda Colak, Ertugrul Cagri Bolek, Suleyman Serdar Koca, Umut Kalyoncu, Ozan Cemal Icacan, Serdal Ugurlu, Hande Ece Oz, Vedat Hamuryudan, Gulen Hatemi
Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Azam Safary, Kamal Esalatmanesh, Amir Taher Eftekharsadat, Mohammad -Reza Jafari Nakjavani, Alireza Khabbazi
Summary: Vaccination against COVID-19 is important for achieving herd immunity and controlling the pandemic. However, a small number of people may develop autoimmune rheumatic diseases (ARDs) as a rare adverse reaction to the vaccines. This study identifies individuals who developed de-novo ARDs after COVID-19 vaccination, with a higher prevalence among those who received the AstraZeneca vaccine. Prompt diagnosis and treatment can prevent irreversible organ damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Israel Valverde, Yogen Singh, Joan Sanchez-de-Toledo, Paraskevi Theocharis, Ashish Chikermane, Sylvie Di Filippo, Beata Kucinska, Savina Mannarino, Amalia Tamariz-Martel, Federico Gutierrez-Larraya, Giridhar Soda, Kristof Vandekerckhove, Francisco Gonzalez-Barlatay, Colin Joseph McMahon, Simona Marcora, Carlo Pace Napoleone, Phuoc Duong, Giulia Tuo, Antigoni Deri, Gauri Nepali, Maria Ilina, Paolo Ciliberti, Owen Miller
Summary: The study documented cardiovascular clinical findings, cardiac imaging, and laboratory markers in children with multisystem inflammatory syndrome associated with COVID-19 infection. Most children in the study cohort had cardiac complications and significantly raised levels of inflammatory markers.
Article
Immunology
Purbita Bandopadhyay, Ranit D'Rozario, Abhishake Lahiri, Jafar Sarif, Yogiraj Ray, Shekhar Ranjan Paul, Rammohan Roy, Rajshekhar Maiti, Kausik Chaudhuri, Saugata Bagchi, Ayan Maiti, Mohammed Masoom Perwez, Biswanath Sharma Sarkar, Devlina Roy, Rahul Chakraborty, Janani Srinivasa Vasudevan, Sachin Sharma, Durba Biswas, Chikam Maiti, Bibhuti Saha, Prasun Bhattacharya, Rajesh Pandey, Shilpak Chatterjee, Sandip Paul, Dipyaman Ganguly
Summary: This study found that convalescent plasma therapy (CPT) has an anti-inflammatory role in COVID-19 patients beyond the presence of neutralizing antibodies. CPT can significantly reduce circulating interleukin-6 and interferon-gamma-inducible protein 10, leading to rapid alleviation of hypoxia.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Peripheral Vascular Disease
Rama Lakshman, Ana-Mishel Spiroski, Lauren B. McIver, Michael P. Murphy, Dino A. Giussani
Summary: Research has shown that pregnancy complicated by chronic fetal hypoxia and oxidative stress can program cardiovascular dysfunction in adult offspring. This study using animal models found that analyzing blood pressure variability and heart rate variability can identify cardiovascular dysfunction in offspring, and that MitoQ may offer protection against programmed endothelial dysfunction.
Article
Public, Environmental & Occupational Health
Namin Wei, Yan Xu, Huan Wang, Qiulei Jia, Xintian Shou, Xuesong Zhang, Nan Zhang, Yanan Li, Huaqiang Zhai, Yuanhui Hu
Summary: This study conducted a bibliometric and visual analysis of the published relationship between cardiovascular diseases (CVDs) and COVID-19, revealing a wide range of research interests in specific diseases, pathogenesis, therapeutic drugs, and clinical characteristics.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Fatima Rodriguez, Nicole Solomon, James A. de Lemos, Sandeep R. Das, David A. Morrow, Steven M. Bradley, Mitchell S. Elkind, Joseph H. Williams, DaJuanicia Holmes, Roland A. Matsouaka, Divya Gupta, Ty J. Gluckman, Marwah Abdalla, Michelle A. Albert, Clyde W. Yancy, Tracy Y. Wang
Summary: The study aimed to identify racial and ethnic differences in presentation and outcomes for COVID-19 patients hospitalized in the United States. Despite adjusting for sociodemographic and clinical differences, Black and Hispanic patients had a greater burden of mortality and morbidity compared to non-Hispanic White patients. Although in-hospital mortality and major adverse cardiovascular events did not differ by race/ethnicity after adjustment, disparities in health outcomes still exist among different racial and ethnic groups in COVID-19 hospitalizations.
Review
Cell Biology
Fan Liu, Feng Liu, Lu Wang
Summary: COVID-19, caused by SARS-CoV-2, not only affects the lungs but also has severe implications in the cardiovascular system. Understanding the mechanisms of cardiovascular injury in COVID-19 patients is crucial for appropriate identification and treatment.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)